Compounds > sb 203580
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sb 203580 and Heart Disease, Ischemic

sb 203580 has been researched along with Heart Disease, Ischemic in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (20.00)18.2507
2000's28 (70.00)29.6817
2010's4 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hu, X; Jiang, H; Wang, J; Xie, J; Zhou, X1
Bellahcene, M; Cao, XB; Clark, JE; Dighe, K; Fisher, SG; Gaestel, M; Gorog, DA; Heads, RJ; Jabr, RI; Kabir, AM; Kato, K; Marber, MS; Quinlan, RA; Sarafraz, N; Tanno, M1
Avkiran, M; Bassi, R; Clark, JE; Jacquet, S; Kumphune, S; Marber, MS; O'Keefe, SJ; Sicard, P; Verma, S1
Pillai, MS; Sapna, S; Shivakumar, K1
Dodd, T; Jadhav, R; Rocic, P; Russell, JC; Smith, E; Stewart, J; Wiggins, L1
Belosjorow, S; Gres, P; Heusch, G; Jansen, J; Michel, MC; Schulz, R1
Belosjorow, S; Duschin, A; Gres, P; Heusch, G; Konietzka, I; Schulz, R; Skyschally, A1
Bouchard, JF; Lagneux, C; Lamontagne, D; Lépicier, P1
Bassi, R; Davis, RJ; Flavell, RA; Gorog, DA; Heads, RJ; Jiang, J; Marber, MS; Martin, JL; Saurin, AT; Tanno, M1
Genade, S; Hattingh, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA1
Bellahcene, M; Cao, X; Gorog, DA; Marber, MS; Quinlan, RA; Tanno, M1
Galiñanes, M; Hassouna, A; Loubani, M1
Hou, R; Xiao, RP; Zheng, M1
Fujiwara, H; Imamura, H; Kido, M; Kyoi, S; Nakao, Y; Okada, T; Otani, H; Sumida, T1
Kimura, H; Liu, S; Matsumoto, K; Nakajima, M; Shintani-Ishida, K; Yoshida, K1
Galiñanes, M; Kubal, C; Nadal-Ginard, B; Sheth, K1
Clanachan, AS; Dyck, JR; Finegan, BA; Gandhi, M; Jaswal, JS1
Ayuzawa, R; Eguchi, R; Kaji, K; Miyakaze, S; Ohta, T; Suzuki, A1
Ali, IS; Currie, RW; Li, G1
Lin, H; Liu, F; Qiao, Y; Wang, B; Wang, R; Yin, H; Zhang, J1
Cohen, MV; Downey, JM; Liu, GS; Weinbrenner, C1
Clerk, A; Fuller, SJ; Michael, A; Sugden, PH1
Clerk, A; Lazou, A; Sugden, PH1
Das, DK; Maulik, N; Price, BD; Sato, M1
Nagarkatti, DS; Sha'afi, RI1
Mackay, K; Mochly-Rosen, D1
Christopher, TA; Feuerstein, GZ; Gao, F; Kumar, S; Lee, JC; Lopez, BL; Louden, CS; Ma, XL; Wang, C; Yue, TL1
Banerjee, A; Cain, BS; Dinarello, CA; Harken, AH; Meldrum, DR; Meng, X; Shames, BD1
Barancik, M; Htun, P; Kilian, S; Schaper, W; Strohm, C1
Feuerstein, GZ; Gu, JL; Kumar, S; Lee, JC; Ma, XL; Maleeff, B; Ohlstein, EH; Thomas, H; Wang, C; Yue, TL1
Heads, RJ; Marber, MS; Mockridge, JW1
Cordis, GA; Das, DK; Maulik, N; Sato, M1
Genade, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA; Strijdom, JG1
Wang, PH1
Anversa, P; Bishopric, NH; Discher, DJ; Kajstura, J; Wasserlauf, BJ; Webster, KA; Yamashita, K1
Fryer, RM; Gross, GJ; Hsu, AK1
Atluri, S; Kukreja, RC; Tejero-Taldo, MI; Tekin, D; Xi, L; Zhao, T1
Fryer, RM; Gross, GJ; Hsu, AK; Patel, HH1
Avkiran, M; Cohen, P; Marber, MS; Martin, JL; Quinlan, RA1
Genade, S; Lochner, A; Marais, E; Moolman, JA; Strijdom, H1

Other Studies

40 other study(ies) available for sb 203580 and Heart Disease, Ischemic

ArticleYear
[Selectively stimulating β1-adrenergic receptor attenuates rat myocardial ischemia/reperfusion injury in vivo by inhibiting high mobility group box 1 protein release].
    Zhonghua xin xue guan bing za zhi, 2014, Volume: 42, Issue:8

    Topics: Animals; Chromones; Dobutamine; HMGB1 Protein; Imidazoles; Interleukin-6; Male; Morpholines; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2014
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
    Cell stress & chaperones, 2009, Volume: 14, Issue:5

    Topics: Animals; Enzyme Activation; Heat-Shock Proteins, Small; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Signal Transduction

2009
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
    The Journal of biological chemistry, 2010, Jan-29, Volume: 285, Issue:5

    Topics: Animals; Enzyme Activation; Humans; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Models, Biological; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Tyrosine

2010
p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:6

    Topics: Animals; Cells, Cultured; Cyclin A; Cyclin D; Cyclin-Dependent Kinase Inhibitor p27; Fibroblasts; G1 Phase; Gene Expression Regulation; Hypoxia; Imidazoles; Male; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; S Phase; S-Phase Kinase-Associated Proteins

2011
MMPs 2 and 9 are essential for coronary collateral growth and are prominently regulated by p38 MAPK.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:6

    Topics: Animals; Collagen Type IV; Collateral Circulation; Coronary Vessels; Elastin; Enzyme Activation; Imidazoles; Laminin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

2011
p38 MAP kinase is a mediator of ischemic preconditioning in pigs.
    Cardiovascular research, 2002, Aug-15, Volume: 55, Issue:3

    Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardium; Organic Chemicals; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Swine, Miniature; Time Factors

2002
Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:10

    Topics: Animals; Connexin 43; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Kinetics; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Models, Biological; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Pyridines; Swine

2003
Endocannabinoids protect the rat isolated heart against ischaemia.
    British journal of pharmacology, 2003, Volume: 139, Issue:4

    Topics: Amides; Animals; Arachidonic Acids; Biomarkers; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Endocannabinoids; Ethanolamines; Glycerides; Heart; Imidazoles; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Piperidines; Protein Kinase C; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction

2003
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
    Circulation research, 2003, Aug-08, Volume: 93, Issue:3

    Topics: Animals; Carrier Proteins; Cells, Cultured; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Kinase 3; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myoblasts; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha

2003
Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK.
    Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:3

    Topics: Animals; Anisomycin; Anthracenes; Cardiac Output; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar

2003
Tumor necrosis factor-induced protection of the murine heart is independent of p38-MAPK activation.
    Journal of molecular and cellular cardiology, 2003, Volume: 35, Issue:12

    Topics: Animals; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Time Factors; Tumor Necrosis Factor-alpha

2003
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
    Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3

    Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture Techniques; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Female; Heart Atria; Humans; Hydroxy Acids; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors

2004
Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:10

    Topics: Acidosis; Animals; Cells, Cultured; Enzyme Inhibitors; Hydrogen-Ion Concentration; Imidazoles; Intracellular Fluid; Myocardial Contraction; Myocardial Ischemia; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats

2004
Temporary blockade of contractility during reperfusion elicits a cardioprotective effect of the p38 MAP kinase inhibitor SB-203580.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiotonic Agents; Enzyme Inhibitors; Imidazoles; Kinetics; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley

2005
Ischemic preconditioning or p38 MAP kinase inhibition attenuates myocardial TNF alpha production and mitochondria damage in brief myocardial ischemia.
    Life sciences, 2006, Mar-20, Volume: 78, Issue:17

    Topics: Animals; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation

2006
Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans.
    The Journal of thoracic and cardiovascular surgery, 2006, Volume: 132, Issue:5

    Topics: Alkaloids; Apoptosis; Benzophenanthridines; Bone Marrow Cells; Cell Death; Heart; Heart Atria; Humans; Imidazoles; In Vitro Techniques; Models, Cardiovascular; Myocardial Ischemia; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Phosphotransferases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines

2006
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:4

    Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Coronary Circulation; Enzyme Inhibitors; Glucose; Glycogen; Imidazoles; Male; Multienzyme Complexes; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley

2007
Hypoxia-induced apoptosis and tube breakdown are regulated by p38 MAPK but not by caspase cascade in an in vitro capillary model composed of human endothelial cells.
    Journal of cellular physiology, 2007, Volume: 211, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Capillaries; Caspase 3; Caspase Inhibitors; Cell Nucleus; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Imidazoles; In Vitro Techniques; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Umbilical Veins

2007
Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:1

    Topics: Animals; Blotting, Western; Densitometry; Disease Models, Animal; Dystrophin; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypothermia, Induced; Imidazoles; Insulin; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Tubulin; Ventricular Function, Left

2008
p38 mitogen-activated protein kinase inhibition decreases TNFalpha secretion and protects against left ventricular remodeling in rats with myocardial ischemia.
    Inflammation, 2008, Volume: 31, Issue:2

    Topics: Actins; Animals; Blotting, Western; Collagen Type I; Coronary Vessels; Disease Models, Animal; Down-Regulation; Echocardiography; Fibrosis; Imidazoles; Immunohistochemistry; Injections, Intraperitoneal; Ligation; Microscopy, Electron, Transmission; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Ventricular Remodeling

2008
Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:9

    Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Densitometry; Enzyme Activation; Enzyme Inhibitors; Heart; Hemodynamics; Imidazoles; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Models, Statistical; Myocardial Ischemia; Myocardium; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rabbits; Tyrosine

1997
Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses.
    The Journal of biological chemistry, 1998, Mar-27, Volume: 273, Issue:13

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Heart; Humans; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Perfusion; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley

1998
Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart.
    The Biochemical journal, 1998, Jun-01, Volume: 332 ( Pt 2)

    Topics: Adrenergic alpha-Agonists; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Heart; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Reperfusion; Tetradecanoylphorbol Acetate

1998
An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia.
    FEBS letters, 1998, Jun-16, Volume: 429, Issue:3

    Topics: Adaptation, Physiological; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Creatine Kinase; Genistein; Heart; Imidazoles; In Vitro Techniques; Malondialdehyde; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptides; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

1998
Role of p38 MAP kinase in myocardial stress.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:8

    Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Tetradecanoylphorbol Acetate

1998
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.
    The Journal of biological chemistry, 1999, Mar-05, Volume: 274, Issue:10

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Heart Ventricles; Imidazoles; Mitogen-Activated Protein Kinases; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley

1999
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion.
    Circulation, 1999, Apr-06, Volume: 99, Issue:13

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Imidazoles; In Situ Nick-End Labeling; In Vitro Techniques; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits; Time Factors

1999
p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function.
    The Journal of surgical research, 1999, May-01, Volume: 83, Issue:1

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Imidazoles; In Vitro Techniques; Mitogen-Activated Protein Kinases; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha

1999
Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:3

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hemodynamics; Imidazoles; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Swine

2000
Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.
    Circulation research, 2000, Mar-31, Volume: 86, Issue:6

    Topics: Animals; Animals, Newborn; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function

2000
Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.
    Biochemical and biophysical research communications, 2000, Apr-21, Volume: 270, Issue:3

    Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genistein; Imidazoles; Kinetics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Wortmannin

2000
SAPKs regulation of ischemic preconditioning.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:3

    Topics: Animals; Anisomycin; Curcumin; Enzyme Inhibitors; Heart; Imidazoles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley

2000
Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:4

    Topics: Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar

2001
Roads to survival: insulin-like growth factor-1 signaling pathways in cardiac muscle.
    Circulation research, 2001, Mar-30, Volume: 88, Issue:6

    Topics: Animals; Apoptosis; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Insulin-Like Growth Factor I; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction

2001
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
    Circulation research, 2001, Mar-30, Volume: 88, Issue:6

    Topics: Androstadienes; Animals; Apoptosis; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Female; Genotype; Imidazoles; Insulin-Like Growth Factor I; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Perfusion; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin

2001
ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection.
    Basic research in cardiology, 2001, Volume: 96, Issue:2

    Topics: Analgesics; Animals; Blood Pressure; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid

2001
Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:2

    Topics: Animals; Enzyme Inhibitors; Heat Stress Disorders; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myocardial Contraction; Myocardial Ischemia; Phosphorylation; Pyridines; Signal Transduction

2001
Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:3

    Topics: Animals; Coronary Vessels; Cytoprotection; Enzyme Inhibitors; Hemodynamics; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta; Reperfusion Injury

2001
Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase.
    Circulation research, 2001, Oct-26, Volume: 89, Issue:9

    Topics: Adenoviridae; Animals; Animals, Newborn; Binding Sites; Cell Survival; Cells, Cultured; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Imidazoles; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reperfusion Injury

2001
p38 MAPK activation triggers pharmacologically-induced beta-adrenergic preconditioning, but not ischaemic preconditioning.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:12

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Isoproterenol; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; p38 Mitogen-Activated Protein Kinases; Perfusion; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, beta

2001