sb 203580 has been researched along with Disease Models, Animal in 159 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.63) | 18.2507 |
| 2000's | 50 (31.45) | 29.6817 |
| 2010's | 93 (58.49) | 24.3611 |
| 2020's | 15 (9.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bookland, RG; Brugel, TA; Clark, CM; Clark, MP; De, B; Djung, JF; Golebiowski, A; Hsieh, LC; Janusz, MJ; Laufersweiler, MJ; Laughlin, SK; Mekel, MJ; Sabat, MP; Townes, JA; VanRens, JC; Walter, RL; Webster, ME | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cai, WJ; Lan, CN; Shi, J; Yi, ZJ | 1 |
| Chen, G; Chen, Y; Feng, F; Huang, S; Jia, Y; Su, W; Xue, P; Yang, T; Zhao, Y; Zhu, Z | 1 |
| Churin, AA; Fomina, TI; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Bhavan, PS; Chung, CL; Hou, SM; Hsia, CH; Hsia, CW; Huang, WC; Jayakumar, T; Sheu, JR; Wu, MP | 1 |
| Chen-Yu Hsu, A; Guan, X; Guo, Y; Pang, Z; Ran, N; Wang, F; Wang, G; Wang, Z; Yuan, Y; Zheng, R | 1 |
| Dong, SA; Gong, LR; Kan, YX; Lian, Y; Shi, J; Yu, JB; Zhao, DH | 1 |
| Ding, Y; Li, X | 1 |
| Chen, W; Fan, HN; Fan, LN; Wu, JT; Zhang, J; Zhu, JS | 1 |
| Chai, ZT; Ding, JD; Duan, KY; Liu, XW; Zhang, HW; Zhang, ZS; Zhao, SS; Zhao, WF; Zhu, BQ | 1 |
| Dai, H; Ge, W; Lin, F; Pan, L; Pei, S; Wang, X; Zhang, S; Zhang, W; Zhao, C | 1 |
| Chen, J; Dai, Y; Li, G; Nie, X; Tan, J; Yang, X; Yang, Z; Zhao, J; Zou, J | 1 |
| Abou-Kheir, W; Bahmad, HF; Ballout, F; Daouk, R; Kadara, H; Monzer, A; Saleh, E | 1 |
| Chen, J; Chen, X; Chu, L; Ding, Z; Guo, T; Hou, R; Huang, Z; Liang, H; Liang, J; Liao, J; Liu, S; Song, S; Tan, X; Wang, Y; Wen, J; Wu, Y; Yang, C; Zhang, B; Zhang, J; Zhang, Z | 1 |
| Chen, D; Fang, Q; Li, N; Qiu, Y; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, N; Zhang, Q; Zhang, R; Zhang, T | 1 |
| Hoshi, T; Hwang, GW; Matsuzawa, A; Naganuma, A; Noguchi, T; Saito, Y; Toyama, T | 1 |
| Hong, Y; Li, M; Mei, F; Wang, W; Yu, J; Zhang, J; Zhao, L; Zuo, T | 1 |
| Cai, J; Chen, J; Jia, L; Sun, B; Xue, X; Zhao, W | 1 |
| Beitz, AJ; Kaang, BK; Kim, YH; Ko, HG; Kwon, SG; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Huang, Q; Huang, Y; Liao, Y; Liu, X; Ma, M; Wei, X; Wu, Y | 1 |
| Chen, CH; Chen, NF; Chen, WF; Feng, CW; Huang, SY; Sung, CS; Wen, ZH; Wong, CS | 1 |
| Chen, J; Dong, J; Fu, C; Guo, Z; Li, N; Liu, Y; Wang, R; Wang, S; Yang, J; Yuan, Y; Zhang, Y | 1 |
| Han, M; Hu, R; Huang, G; Li, H; Liu, H; Liu, X; Liu, Y; Otsu, K; Xiao, S; Zhao, W; Zheng, T | 1 |
| Chen, J; Gui, C; Li, W; Mao, K; Ren, Y; Wu, X; Zhao, M; Zou, F | 1 |
| Dong, SA; Gong, LR; Kang, YY; Li, XY; Shi, J; Yu, JB; Zhang, Y | 1 |
| Chen, Y; Jiang, H; Liu, J | 1 |
| Koizumi, N; Nakahara, M; Nakano, S; Okumura, N | 1 |
| Jiang, Z; Li, D; Ren, W; Zhu, L | 1 |
| Cai, C; He, B; Lei, C; Ruan, Y; Zhao, D | 1 |
| Fan, C; Li, Y; Song, Q; Wang, P; Yang, M; Yu, SY | 1 |
| Feng, XR; Liu, ZC; Lu, HD; Wang, B; Zhou, J; Zhou, LY | 1 |
| Chen, XR; Han, QQ; Huang, HJ; Li, B; Liu, Q; Pilot, A; Wang, J; Wang, YL; Wu, GC; Yang, L; Yu, J; Yu, R; Zhu, XC | 1 |
| Cao, X; Chen, G; Jia, M; Li, J; Liu, Q; Nie, S; Wang, C; Xu, Y; Zeng, W; Zheng, C | 1 |
| Ding, C; Guo, J; Qian, F; Qian, Y; Shen, M; Zhang, W; Zhao, L | 1 |
| Bian, ZZ; Pan, XT; Wan, YD; Zhu, RX | 1 |
| Beitz, AJ; Choi, SR; Lee, JH | 1 |
| Beckmann, T; Boehncke, WH; Hänsel, M; Hellberg, L; Holdorf, K; Kirchner, T; Laskay, T; Ludwig, RJ; Möckel, N; Recke, A; Samavedam, UKSRL; Schmidt, E; Solbach, W; Steinhorst, K; Zillikens, D | 1 |
| Fu, W; Hu, X; Jiang, H; Wang, J; Xie, J; Xu, W; Yang, H; Zhou, X | 1 |
| Chen, KF; Lin, YX; Pan, YX; Shi, JX; Wu, W; Zhang, X; Zhang, XS; Zhou, XM | 1 |
| Chen, Y; Huang, L; Hui, L; Li, Y; Wan, J; Wang, Z; Xu, D; Zhou, W | 1 |
| Bowman, L; Ding, M; Hou, L; Meighan, TG; Shi, X | 1 |
| Calkins, DJ; Crish, SD; Dapper, JD; Pang, IH | 1 |
| Endoh, D; Hayashi, M; Imaizumi, Y; Kadowaki, S; Meguro, S; Sakai, H | 1 |
| He, DK; Li, W; Shao, YR; Shen, J; Yuan, Z | 1 |
| Ali, S; Amir, M; Somakala, K | 1 |
| Bae, DW; Choi, BT; Choi, YW; Hong, JW; Jang, JY; Kim, HN; Kim, YR; Park, SJ; Shin, HK | 1 |
| He, L; Ma, X; Zhang, Y; Zou, J | 1 |
| Beaulieu, LM; Benjamin, EJ; Freedman, JE; Genco, CA; Koupenova, M; Kramer, CD; Larson, MG; Lin, E; Mick, E; Tanriverdi, K; Weinberg, EO | 1 |
| Fang, MY; Li, YX; Tang, QQ; Wang, XY; Zhang, JL | 1 |
| Wu, H; Zhang, L; Zhang, Z; Zhou, C | 1 |
| Liu, M; Mao, T; Sun, N; Wang, Q; Wei, Z; Zhang, H; Zhang, Y; Zhang, Z | 1 |
| Bertz, J; Gladbach, A; Ittner, AA; Ittner, LM; Suh, LS | 1 |
| Ahmad, S; Bhatia, K; Elsherbini, AM; Elsherbiny, NM; Fulzele, S; Liou, GI | 1 |
| Cai, HD; Cao, MH; Chen, CQ; Feng, YJ; Li, K; Li, YY; Lv, ZW; Xu, J | 1 |
| Bao, M; Chao, Y; Chen, Z; Guan, Y; Guo, R; Li, X; Lin, C; Wang, Y; Wu, A; Xie, F; Yue, Y; Zhang, C | 1 |
| He, B; Liu, SQ; Mei, HJ; Wu, SH; Xia, SQ; Yu, L; Zhao, Q; Zhou, Y | 1 |
| Gong, S; Liu, Q; Liu, S; Wu, H; Yao, S; Yu, Y | 1 |
| Han, X; Li, GX; Li, ZS; Liu, G; Liu, J; Zhang, L; Zou, DW | 1 |
| Chu, YX; Huang, B; Li, HB; Liu, MJ; Ni, HD; Wang, HQ; Xu, LS; Xu, SJ; Yao, M; Zheng, Y | 1 |
| Beitz, AJ; Kim, SJ; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Chen, X; Liu, H; Liu, W; Liu, Y; Xie, Y; Xu, X; Zhang, W | 1 |
| Boecker, A; Evers, D; Jonas, R; Keller, V; Pogatzki-Zahn, EM; Reichl, S; Segelcke, D; Wenk, M; Zahn, PK | 1 |
| Bian, Y; Ding, J; Hu, G; Lu, M; Shan, H; Shu, Z; Xiao, M; Zhang, L; Zhu, J | 1 |
| Cao, L; Malon, JT | 1 |
| Choi, DY; Han, SB; Hong, JT; Hwang, CJ; Hwang, DY; Jeong, HS; Kim, SY; Kim, TH; Kim, YM; Lee, HJ; Lee, HP; Lee, TH; Moon, DB; Oh, KW; Park, SS | 1 |
| Chang, L; Guo, J; Guo, Z; Li, C; Li, M; Wang, C; Wang, Q; Yan, P; Zha, Q | 1 |
| Askar, I; Chan, D; Flanagan, JG; Guo, X; Lam, S; Livne-Bar, I; Nahirnyj, A; Sivak, JM | 1 |
| Chen, G; Deng, L; Song, F; Zhang, L; Zhao, H; Zhu, H | 1 |
| Gao, B; Meng, X; Sun, W; Xue, D; Zhang, W | 1 |
| Augustynik, M; Biermann, J; Buerkle, H; Goebel, U; Kaufmann, KB; Lagrèze, WA; Meske, A; Ramao, CC; Ulbrich, F | 1 |
| Gao, F; Li, S; Liu, C; Sun, D; Wang, Y; Wang, Z | 1 |
| Agafonov, VI; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Minakova, MY; Miroshnichenko, LA; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Cao, MH; Feng, YJ; Li, K; Li, YY; Lin, XH | 1 |
| He, ZY; Luo, XG; Shang, H; Wang, XH; Xie, X | 1 |
| Che, X; Mou, S; Ni, Z; Shao, X; Tian, L; Wang, Q; Xie, Y; Xu, W; Xu, Y; Zhang, M | 1 |
| Concepcion, FA; D'Ambrosio, R; Fender, J; Jones, TD; Jung, S; Liu, Y; Neumaier, JF; Poolos, NP; Skyrud, DW; Tai, TY; Warner, LN; Williams, AD | 1 |
| Liu, J; Plunet, W; Steeves, JD; Stirling, DP; Tetzlaff, W | 1 |
| Davies, NA; Hodges, SJ; Jalan, R; Pitsillides, AA; Shawcross, DL; Stadlbauer, V; Wheeler-Jones, C; Wright, GA | 1 |
| Campana, WM; Hefferan, MP; Jones-Cordero, TL; Sorkin, L; Svensson, CI | 1 |
| Behren, A; Iftner, T; Mühlen, S; Plinkert, PK; Simon, C | 1 |
| Choi, DY; Huh, JE; Jeon, G; Lee, JD; Park, DS; Woo, HS; Yang, HR | 1 |
| Brown, D; Hikim, AP; Kovacheva, EL; Sinha-Hikim, I | 1 |
| Peacock, AJ; Wadsworth, RM; Weerackody, RP; Welsh, DJ | 1 |
| Bradesi, S; Mayer, EA; Pothoulakis, C; Steinauer, J; Svensson, CI; Yaksh, TL | 1 |
| Hayashi, Y; Nguyen, SV; Nguyen, TM; Purdy, RE; Summers, SM | 1 |
| Fang, F; Fu, YQ; Hu, L; Kuang, FW; Li, J; Lu, ZY; Tan, LP; Xu, F | 1 |
| Barone, FC; Dreixler, JC; Du, E; Roth, S; Shaikh, AR | 1 |
| Chan, JY; Chan, SH; Chang, AY; Ho, YH; Wu, CA; Wu, KL | 1 |
| Dimmeler, S; Haendeler, J; Langheinrich, AC; Sedding, D; Seeger, FH; Zeiher, AM | 1 |
| Li, Q; Li, WM; Zhang, J; Zou, P | 1 |
| Belfort, R; Belfort, RN; Bombardieri, CR; Commodaro, AG; de Camargo, MM; Guedes, PM; Hamassaki, DE; Peron, JP; Rizzo, LV; Saito, KC | 1 |
| Awazu, M; Fujita, H; Fukuda, K; Hida, M; Kanemoto, K; Nagata, M | 1 |
| Armstead, WM; Cines, DB; Higazi, AA; Kiessling, JW; Riley, J | 2 |
| Tapia, R; Tovar-Y-Romo, LB | 1 |
| Blakely, RD; Daws, LC; Hewlett, WA; Lindler, KM; Owens, AW; Zhu, CB | 1 |
| Bhaskar, K; Cardona, A; Kokiko-Cochran, ON; Konerth, M; Lamb, BT; Ransohoff, RM | 1 |
| Burstein, R; Kainz, V; Levy, D; Zhang, XC | 1 |
| Al Ghouleh, I; Cascino, T; Csanyi, G; Haurani, MJ; Montezano, AC; Pagano, PJ; Touyz, RM | 1 |
| Liu, FC; Liu, FW; Yu, HP | 1 |
| Agrawal, S; Benndorf, R; Guess, AJ; Manley, J; Mourey, RJ; Pengal, R; Ransom, RF; Smoyer, WE | 1 |
| Choi, KC; Kook, SH; Lee, JC; Lee, SA; Son, YO | 1 |
| Castaño, A; García-Cuervo, L; Jiménez, S; Pintado, C; Revilla, E; Ruano, D; Vitorica, J; Vizuete, ML | 1 |
| Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ | 1 |
| Gao, YJ; Huang, L; Strichartz, G; Wang, J | 1 |
| Bernstein, HS; Boyle, A; Gaur, M; Prasad, M; Ritner, C; Sievers, RE; Yeghiazarians, Y; Zhang, Y | 1 |
| Shi, JX; Yin, HX; Zhang, X; Zhao, XD | 1 |
| Braem, K; Lories, RJ; Luyten, FP | 1 |
| Hirate, Y; Kasai, K; Yamaguchi, M | 1 |
| Chatterjee, A; Mahata, SK; Mir, SA; Mitra, A; Pathak, K; Sarkar, S | 1 |
| Huang, B; Khatibi, N; Ma, Q; Rolland, W; Suzuki, H; Tang, J; Zhang, JH | 1 |
| Downey, HF; Ju, X; Jung, ME; Mallet, RT; Metzger, DB | 1 |
| Jang, H; Kim, K; Kim, S; Lee, SA; Rhim, BY; Son, Y | 1 |
| Ganesh Kumar, N; Hosmane, S; Rajbhandari, L; Tegenge, MA; Thakor, N; Uapinyoying, P; Venkatesan, A | 1 |
| Chu, H; Gao, J; Liu, S; Xia, J; Xu, H; Yang, Z | 1 |
| Chattipakorn, N; Chattipakorn, S; Kumphune, S; Surinkaew, S | 1 |
| Kondo, T; Miwa, H; Noguchi, K; Sakurai, J | 1 |
| Lyons, D; Ma, F; Westlund, KN; Zhang, L | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Butters, KA; Cheng, J; Garovic, VD; Grande, JP; Gray, CE; Knudsen, BE; Lerman, LO; Lien, KR; Nath, KA; Simari, RD; Textor, SC; Wang, D; Warner, GM; Yin, P | 1 |
| Han, S; Li, J; Liang, J; Liu, X; Luo, Y; Wang, Y; Yin, Y; Zhao, L | 1 |
| Ben, DF; Chen, XL; Wang, GQ; Wei, D; Xia, ZF | 1 |
| Han, PL; Kim, JB; Lee, JK; Piao, CS | 1 |
| Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
| Genade, S; Hattingh, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA | 1 |
| Zheng, S; Zuo, Z | 1 |
| Aletsee, C; Austen, D; Kayali, AG; Melhus, A; Pak, K; Palacios, SD; Rivkin, AZ; Ryan, AF; Webster, NJ | 1 |
| Hollenbach, E; Malfertheiner, P; Naumann, M; Neumann, M; Roessner, A; Vieth, M | 2 |
| Jing, XL; Le, S; Liang, YB; Ma, ZF; Tang, H; Zhan, H | 1 |
| Akamastu, S; Ishisaki, A; Kanno, Y; Kato, K; Kitajima, Y; Kozawa, O; Matsuno, H; Nakajima, K; Shu, E; Suga, H; Takai, S | 1 |
| Becker, TC; Cao, W; Collins, QF; Collins, S; Daniel, KW; Floering, L; Lupo, EG; Robidoux, J; Xiong, Y | 1 |
| Heuertz, RM; Nash, SP | 1 |
| Albina, JE; LeBlanc, BW; Reichner, JS | 1 |
| Arimura, Y; Endo, T; Goto, A; Imai, K; Kobayashi, K; Okahara, S; Shinomura, Y | 1 |
| Dennis, PA; Figg, WD; Lepper, ER; Warfel, NA; Zhang, C | 1 |
| Cabane, C; Colombel, JF; Dérijard, B; Desreumaux, P; Dubuquoy, L; Gay, J; Malamut, G; Malapel, M; Tamboli, C | 1 |
| Albani, S; Boyle, DL; Firestein, GS; Hammaker, D; Jones, TL; Rosengren, S; Sorkin, L; Svensson, CI | 1 |
| Adeli, K; Avramoglu, RK; Qin, B; Qiu, W | 1 |
| Bland, KI; Chaudry, IH; Chen, JG; Choudhry, MA; Hsieh, YC; Hsu, JT; Kan, WH; Schwacha, MG | 1 |
| Chilian, WM; Kolz, C; Potter, B; Reed, R; Rocic, P | 1 |
| Bollag, WB; Borke, J; Camba, AM; Dickinson, DP; Hsu, SD; Ogbureke, KU; Qin, H; Schuster, GS; Sharawy, MM; Stöppler, HJ; Winger, JN | 1 |
| Chen, JD; Gan, HT; Pasricha, PJ | 1 |
| Chang, WJ; Chen, LW; Chen, PH; Hsu, CM; Karin, M; Wang, JS | 1 |
| Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Lee, MK; Lim, EJ; Yang, GY | 1 |
| Han, JS; Kim, JM; Kim, YJ; Lee, JY; Oh, YK; Park, HR; Youn, J | 1 |
| Jia, YT; Ma, X; Qiu, DK | 1 |
| Cheng, G; Padbury, JF; Tseng, YT; Zhang, LX; Zhao, TC | 1 |
| Ali, IS; Currie, RW; Li, G | 1 |
| Lin, H; Liu, F; Qiao, Y; Wang, B; Wang, R; Yin, H; Zhang, J | 1 |
| Feng, Y; Kuang, D; Ni, J; Wang, G; Wu, R; Xiao, G; Zhao, X | 1 |
| Feng, G; Liu, GJ; Liu, S; Wang, GL | 1 |
| Ba, ZF; Bland, KI; Chaudry, IH; Chen, J; Choudhry, MA; Hsu, JT; Kan, WH; Schwacha, MG | 1 |
| Adams, JL; Badger, AM; Bradbeer, JN; Griswold, DE; Lee, JC; Votta, B | 1 |
| Belvisi, MG; Birrell, MA; Escott, KJ; Foster, ML; Sargent, CA; Webber, SE | 1 |
| Juffermans, NP; Peppelenbosch, MP; Schultz, MJ; ten Hove, T; van den Blink, B; van der Poll, T; van Deventer, SJ | 1 |
| Aki, T; Asakura, M; Asanuma, H; Fukushima, T; Hatanaka, K; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J; Yoshida, K | 1 |
| Gilmont, RR; Hirano, S; Rees, RS | 1 |
2 trial(s) available for sb 203580 and Disease Models, Animal
| Article | Year |
|---|---|
Intracisternal administration of SB203580, a p38 mitogen-activated protein kinase inhibitor, attenuates cerebral vasospasm via inhibition of tumor-necrosis factor-α.
Topics: Animals; Basilar Artery; Dimethyl Sulfoxide; Disease Models, Animal; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Subarachnoid Hemorrhage; Tumor Necrosis Factor-alpha; Vasospasm, Intracranial | 2013 |
Ammonia impairs neutrophil phagocytic function in liver disease.
Topics: Amino Acids; Ammonia; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Double-Blind Method; Humans; Hyperammonemia; Hyponatremia; Imidazoles; Isoproterenol; Liver Cirrhosis; Liver Diseases; Male; Middle Aged; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Signal Transduction | 2008 |
157 other study(ies) available for sb 203580 and Disease Models, Animal
| Article | Year |
|---|---|
The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Kinetics; Lipopolysaccharides; Models, Molecular; Molecular Conformation; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyrazolones; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2005 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index | 2021 |
Delayed inhibition of ERK and p38 attenuates neuropathic pain without affecting motor function recovery after peripheral nerve injury.
Topics: Animals; Axons; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Male; Mice, Inbred C57BL; Nerve Regeneration; Neuralgia; Nitriles; p38 Mitogen-Activated Protein Kinases; Peripheral Nerve Injuries; Pyridines; Recovery of Function; Sciatic Nerve; Treatment Outcome | 2022 |
Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.
Topics: Animals; Astrocytes; Culture Media, Conditioned; Disease Models, Animal; Ethanol; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Growth Factors; Neurodegenerative Diseases; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Spheroids, Cellular | 2021 |
Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.
Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Free Radical Scavengers; Free Radicals; Humans; I-kappa B Kinase; Imidazoles; Indole Alkaloids; Male; Mice, Inbred ICR; NF-kappa B; Nitriles; P-Selectin; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Protein Kinase Inhibitors; Pulmonary Embolism; Pyridines; Quinazolines; Sulfones; Thrombosis; Transcription Factor RelA | 2022 |
Combined treatment with SB203580 and dexamethasone suppresses non-typeable Haemophilus influenzae-induced Th17 inflammation response in murine allergic asthma.
Topics: Animals; Asthma; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Female; Haemophilus influenzae; Humans; Imidazoles; Inflammation; Lung; Mice; Mucin 5AC; Mucin-5B; Neutrophils; Ovalbumin; p38 Mitogen-Activated Protein Kinases; Pyridines; Respiratory Mucosa; Signal Transduction; Symptom Flare Up; Th17 Cells | 2019 |
Electroacupuncture Attenuates Limb Ischemia-Reperfusion-Induced Lung Injury Via p38 Mitogen-Activated Protein Kinase-Nuclear Factor Erythroid-2-Related Factor-2/Heme Oxygenase Pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Electroacupuncture; Extremities; Femoral Artery; Heme Oxygenase-1; Humans; Imidazoles; Inflammation Mediators; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits; Reperfusion Injury; Treatment Outcome | 2020 |
Resistin Promotes Thrombosis in Rats with Deep Vein Thrombosis via Up-Regulating MMP-2, MMP-9, and PAI-1.
Topics: Aged; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Imidazoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Plasminogen Activator Inhibitor 1; Pyridines; Rats, Sprague-Dawley; Resistin; Up-Regulation; Venous Thrombosis | 2019 |
Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy.
Topics: Acute Disease; Animals; Autophagy; Caspase 1; Cytokines; Disease Models, Animal; Imidazoles; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Pyridines; Signal Transduction | 2019 |
Critical Role of p38 in Spinal Cord Injury by Regulating Inflammation and Apoptosis in a Rat Model.
Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Inflammation; Inflammation Mediators; Locomotion; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries | 2020 |
Ly-6C
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Ly; Benzoxazines; Bone Marrow; Cell Movement; Chemokine CCL2; Disease Models, Animal; Humans; Imidazoles; Lung; Mice; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR2; Spiro Compounds; Tidal Volume; Ventilator-Induced Lung Injury; Ventilators, Mechanical | 2020 |
SB203580 protects against inflammatory response and lung injury in a mouse model of lipopolysaccharide‑induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cytokines; Disease Models, Animal; Gene Expression; Imidazoles; Interferon Regulatory Factors; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines | 2020 |
Genome-wide gene expression analysis of a murine model of prostate cancer progression: Deciphering the roles of IL-6 and p38 MAPK as potential therapeutic targets.
Topics: Androgens; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Imidazoles; Interleukin-6; Male; Mice; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines | 2020 |
H19 Promotes HCC Bone Metastasis Through Reducing Osteoprotegerin Expression in a Protein Phosphatase 1 Catalytic Subunit Alpha/p38 Mitogen-Activated Protein Kinase-Dependent Manner and Sponging microRNA 200b-3p.
Topics: Animals; Bone Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Imidazoles; Liver Neoplasms; Male; Mice; MicroRNAs; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Protein Phosphatase 1; Pyridines; RAW 264.7 Cells; RNA, Long Noncoding; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2021 |
Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Mice; Mice, Knockout; Narcotic Antagonists; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Pain; Pyridines; Receptors, Opioid, mu; Signal Transduction; Spinal Cord Injuries | 2021 |
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia.
Topics: Animals; Apoptosis; Brain; Cell Line; Clodronic Acid; Disease Models, Animal; Environmental Pollutants; Gene Knockdown Techniques; Humans; Imidazoles; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mice; Microglia; Mitochondria; Neurons; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Primary Cell Culture; Pyridines; Tumor Necrosis Factor-alpha | 2021 |
Inhibition of the p38 MAPK pathway attenuates renal injury in pregnant rats with acute necrotizing pancreatitis.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Humans; Imidazoles; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis, Acute Necrotizing; Pregnancy; Pregnancy Complications; Pyridines; Rats | 2021 |
Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Imidazoles; Lung; Male; Malondialdehyde; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Taurine; Tumor Necrosis Factor-alpha | 2021 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Flavonoids; Hyperalgesia; Imidazoles; MAP Kinase Signaling System; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Pain; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Spinal Cord | 2017 |
P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cognition Disorders; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Hippocampus; Imidazoles; Kindling, Neurologic; Male; Maze Learning; p38 Mitogen-Activated Protein Kinases; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Transduction | 2017 |
Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hot Temperature; Hyperalgesia; Imidazoles; Interleukin-1beta; Male; Microglia; Minocycline; Neurons; Nitric Oxide; Nociceptive Pain; Phosphorylation; Pyridines; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Body Weight; Bone Morphogenetic Protein 4; Carrier Proteins; Chronic Disease; Disease Models, Animal; Endothelium, Vascular; Flavonoids; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase Type III; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats, Sprague-Dawley; Surgical Instruments; Systole; Vasodilation | 2018 |
p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation.
Topics: Animals; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Imidazoles; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Langerhans Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Psoriasis; Pyridines; Signal Transduction; Skin; T-Lymphocytes; Th17 Cells | 2018 |
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Enzyme Activation; Humans; Imidazoles; Mice, Transgenic; Mitochondria; Mitophagy; Mutant Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Phosphoserine; Protein Kinases; Pyridines; Synapses; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2018 |
Carbon monoxide attenuates lipopolysaccharide-induced lung injury by mitofusin proteins via p38 MAPK pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; GTP Phosphohydrolases; Humans; Imidazoles; Lipopolysaccharides; Male; MAP Kinase Signaling System; Membrane Proteins; Mitochondrial Dynamics; Mitochondrial Proteins; Organometallic Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2018 |
[Role of p38MAPK signaling pathway in rats with phantom limb pain].
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Male; Mastication; p38 Mitogen-Activated Protein Kinases; Phantom Limb; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Self Mutilation; Signal Transduction; Spinal Cord | 2018 |
Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation.
Topics: Animals; Blotting, Western; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Corneal Injuries; Disease Models, Animal; Endothelial Cells; Endothelium, Corneal; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits | 2018 |
Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury.
Topics: Acute Lung Injury; Animals; Caspases; Disease Models, Animal; Humans; Imidazoles; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Lung; Macrophages; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyroptosis; Respiratory Distress Syndrome; Signal Transduction | 2018 |
Role of P38 mitogen-activated protein kinase on Cx43 phosphorylation in cerebral vasospasm after subarachnoid hemorrhage.
Topics: Animals; Connexin 43; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2019 |
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.
Topics: Adenoviridae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclooxygenase 2; Cytokines; Depression; Dinoprostone; Disease Models, Animal; Food Preferences; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Imidazoles; Lipopolysaccharides; Male; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Stress, Psychological; Swimming | 2018 |
Influence of the TLR4-mediated p38MAPK signaling pathway on chronic intermittent hypoxic-induced rat's oxidative stress and inflammatory cytokines in rats.
Topics: Adipose Tissue; Animals; Antioxidants; Chronic Disease; Cyclic N-Oxides; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hypoxia; Imidazoles; Male; MAP Kinase Signaling System; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sleep Apnea, Obstructive; Spin Labels; Toll-Like Receptor 4 | 2019 |
Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Gene Knockdown Techniques; Ghrelin; Hippocampus; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pyridines | 2019 |
Involvement of p38 mitogen-activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes.
Topics: Animals; Aquaporin 1; Aquaporin 4; Astrocytes; Brain; Brain Edema; Carbon Monoxide Poisoning; Disease Models, Animal; Humans; Imidazoles; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Up-Regulation | 2019 |
Shengjiang Powder ameliorates myocardial injury in septic rats by downregulating the phosphorylation of P38-MAPK.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Heart Injuries; Imidazoles; Interleukin-6; Male; Myocardium; Myocytes, Cardiac; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proliferating Cell Nuclear Antigen; Pyridines; Rats; Rats, Wistar; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Microbiome; Imidazoles; Inflammation; Interleukin-1beta; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Pyridines; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Tumor Necrosis Factor-alpha | 2019 |
Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation.
Topics: Animals; Astrocytes; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Imidazoles; Ketoconazole; Lumbar Vertebrae; Male; Mice; Microglia; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Spinal Cord; Spinal Cord Dorsal Horn; Steroid 17-alpha-Hydroxylase | 2019 |
Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation.
Topics: Adult; Animals; Antigen-Antibody Complex; Autoantibodies; Butadienes; Dermis; Disease Models, Animal; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epidermolysis Bullosa Acquisita; Glucocorticoids; Humans; Imidazoles; MAP Kinase Signaling System; Methylprednisolone; Mice; Mice, Inbred C57BL; Neutrophils; Nitriles; Pemphigoid, Bullous; Pyridines; Reactive Oxygen Species; Respiratory Burst | 2013 |
Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Chromones; Disease Models, Animal; Dobutamine; Enzyme Inhibitors; Heart; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Male; Morpholines; Myocardial Reperfusion Injury; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley | 2013 |
Inhibitory effects of p38 inhibitor against mitochondrial dysfunction in the early brain injury after subarachnoid hemorrhage in mice.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mice; Mitochondrial Diseases; p38 Mitogen-Activated Protein Kinases; Pyridines; Subarachnoid Hemorrhage; Time Factors | 2013 |
Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.
Topics: Animals; Apoptosis Regulatory Proteins; Butadienes; Cell Line; Cell Transformation, Neoplastic; Cobalt; Disease Models, Animal; Enzyme Inhibitors; Epidermis; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; MAP Kinase Signaling System; Mice; MicroRNAs; Mitogen-Activated Protein Kinase Kinases; Nanoparticles; Nitriles; Occupational Exposure; Pyridines; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Tungsten Compounds | 2013 |
Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy.
Topics: Activating Transcription Factor 2; Animals; Axons; Chaperonin 60; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Intraocular Pressure; Mice; Nerve Tissue Proteins; Ocular Hypertension; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Retina; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction; Time Factors | 2013 |
Role of p38 Mapk in development of acute hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model of human Wilson's disease.
Topics: Age Factors; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Hepatolenticular Degeneration; Imidazoles; Liver; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred LEC; Statistics, Nonparametric | 2013 |
[Effects of phosphorylated mitogen-activated protein kinases on phosgene inhalation-induced lung injury in rats and its relationship with matrix metalloproteinase].
Topics: Animals; Burns, Inhalation; Cytokines; Disease Models, Animal; Flavonoids; Imidazoles; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Phosgene; Phosphorylation; Pyridines; Rats; Rats, Wistar | 2013 |
p38 MAP kinase inhibitors as anti inflammatory agents.
Topics: Amides; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Humans; Imidazoles; Indoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Structure-Activity Relationship; Urea | 2013 |
Neuroprotective effects of a novel single compound 1-methoxyoctadecan-1-ol isolated from Uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model.
Topics: Animals; Brain Ischemia; Calpain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Fatty Alcohols; Gene Expression Regulation; Glutamic Acid; Imidazoles; Mice; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Photochemical Processes; Primary Cell Culture; Protein Tyrosine Phosphatases, Non-Receptor; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Thrombosis; Uncaria | 2014 |
Dry eye management in a Sjögren's syndrome mouse model by inhibition of p38-MAPK pathway.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Female; Imidazoles; Lacrimal Apparatus; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; p38 Mitogen-Activated Protein Kinases; Pyridines; Sjogren's Syndrome | 2014 |
Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.
Topics: Animals; Atherosclerosis; Bacteroidaceae Infections; Cell Line; Collagen; Dietary Fats; Disease Models, Animal; Gene Expression Profiling; Humans; Imidazoles; Inflammation; Interleukin-1beta; MAP Kinase Signaling System; Megakaryocytes; Mice; Mice, Knockout; NF-kappa B; Obesity; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Adhesiveness; Porphyromonas gingivalis; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Interleukin-1 Type I; Thrombin; Transcription, Genetic | 2014 |
Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-α and IL-1β in rats with severe acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Down-Regulation; Imidazoles; Immunohistochemistry; Interleukin-1beta; Male; MAP Kinase Signaling System; Pancreas; Pancreatic Function Tests; Pancreatitis; Pyridines; Rats, Wistar; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2014 |
Ketamine inhibits LPS-induced HGMB1 release in vitro and in vivo.
Topics: Animals; Cecum; Cell Line; Disease Models, Animal; HMGB1 Protein; Humans; Imidazoles; Ketamine; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peritonitis; Pyridines; Rats; Rats, Sprague-Dawley; Sepsis | 2014 |
[P38 MAPK signaling pathway regulates nuclear factor-κB and inducible nitric oxide synthase expressions in the substantia nigra in a mouse model of Parkinson's disease].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neurons; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Pyridines; Substantia Nigra | 2014 |
p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Dizocilpine Maleate; Electrodes, Implanted; Electroencephalography; Enzyme Inhibitors; Epilepsy; Excitatory Amino Acid Antagonists; Gamma Rhythm; Hippocampus; Imidazoles; Male; Mice, Inbred C57BL; Mice, Transgenic; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, N-Methyl-D-Aspartate; Riluzole; Theta Rhythm | 2014 |
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
Topics: Adenosine; Adenosine Kinase; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Morpholines; Neurotoxicity Syndromes; Nitric Oxide Synthase Type I; Optic Nerve Injuries; Oxidative Stress; Pyridines; Pyrimidines; Retina | 2014 |
p38 MAPK inhibition alleviates experimental acute pancreatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Biomarkers; Ceruletide; Chaperonin 60; Disease Models, Animal; HSP70 Heat-Shock Proteins; Imidazoles; Inflammation Mediators; Lung; Mice, Inbred C57BL; Mitochondrial Proteins; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Peroxidase; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2015 |
Activation of p38 MAPK in the rostral ventromedial medulla by visceral noxious inputs transmitted via the dorsal columns may contribute to pelvic organ cross-sensitization in rats with endometriosis.
Topics: Adipose Tissue; Animals; Colon; Disease Models, Animal; Endometriosis; Female; Imidazoles; Medulla Oblongata; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Physical Stimulation; Pressure; Protein Kinase Inhibitors; Pyridines; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Transplantation, Autologous; Uterus; Visceral Pain | 2015 |
Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Berberine; Cartilage, Articular; Cell Survival; Chondrocytes; Cytoskeleton; Disease Models, Animal; Imidazoles; Knee Joint; Male; Nitric Oxide; Nitroprusside; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vidarabine | 2015 |
[Protective effect of estrogen on acute lung injury after hemorrhagic shock in pregnant rabbit].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Estrogens; Female; Imidazoles; Interleukin-6; Lung; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pregnancy; Protective Agents; Pyridines; Rabbits; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of p38 MAPK activation attenuates esophageal mucosal damage in a chronic model of reflux esophagitis.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Esophagitis, Peptic; Esophagus; Imidazoles; Immunohistochemistry; Male; Mucous Membrane; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2015 |
Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hyperalgesia; Imidazoles; Male; Microfilament Proteins; Neuroglia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Periaqueductal Gray; Phosphopyruvate Hydratase; Pyridines; Rats; Rats, Sprague-Dawley; Sciatica; Signal Transduction; Time Factors | 2016 |
Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antineoplastic Agents; Blood Pressure; Clonidine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Imidazoles; Male; Mice; Motor Activity; Organoplatinum Compounds; Oxaliplatin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Spinal Cord; Spinal Cord Dorsal Horn | 2016 |
Role of Metallothionein in Post-Burn Inflammation.
Topics: Animals; Burns; Chemokine CCL2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Interleukin-1beta; Interleukin-6; Macrophages; Male; MAP Kinase Signaling System; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2016 |
Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats.
Topics: Action Potentials; Animals; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Flavonoids; Foot; Imidazoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroglia; p38 Mitogen-Activated Protein Kinases; Pain, Postoperative; Posterior Horn Cells; Pyridines; Rats, Sprague-Dawley; Up-Regulation | 2016 |
Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53.
Topics: Animals; Anisomycin; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Fluoxetine; Gene Expression; Imidazoles; Interleukin-1beta; MAP Kinase Signaling System; Mice, Inbred C57BL; Neuroimmunomodulation; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Stroke; Tumor Suppressor Protein p53 | 2016 |
Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Cells, Cultured; Chemokine CCL5; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neuroglia; Pain Threshold; Peptide Fragments; Peripheral Nerve Injuries; Pyridines; Spinal Cord; Spinal Nerves | 2016 |
Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Astrocytes; Behavioral Symptoms; Cell Line; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Imidazoles; Inflammation; Male; Mice; Mice, Inbred ICR; Microglia; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiophenes | 2016 |
SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Depression; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Imidazoles; Male; Maze Learning; Memory Disorders; Mice; Microinjections; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Pyridines; Signal Transduction | 2017 |
Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.
Topics: Animals; Apoptosis; Astrocytes; Corneal Injuries; Disease Models, Animal; Gliosis; Imidazoles; Intermediate Filaments; Male; Mice, Inbred C57BL; Neuroglia; p38 Mitogen-Activated Protein Kinases; Polymerization; Pyridines; Retinal Neurons; Tumor Necrosis Factor-alpha; Withanolides | 2016 |
The role of p38MAPK activation in spinal dorsal horn in remifentanil-induced postoperative hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Enzyme Activation; Hyperalgesia; Imidazoles; Male; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pain, Postoperative; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Remifentanil; Spinal Cord Dorsal Horn; Time Factors | 2016 |
Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis.
Topics: Animals; Apoptosis; Blood Platelets; Bone Marrow Cells; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Hematologic Diseases; Humans; Imidazoles; Liver Cirrhosis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Signal Transduction | 2016 |
The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Coordination Complexes; Disease Models, Animal; Female; Imidazoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Ganglion Cells; RNA, Messenger; Signal Transduction | 2016 |
Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Topics: Animals; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Fibrosis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Kidney; Kidney Diseases; Male; Mice; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Transforming Growth Factor beta1 | 2016 |
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoietin; Flavonoids; Gene Expression Regulation; Hemorrhage; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2016 |
Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Cannabinoid Receptor Agonists; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Imidazoles; Interleukin-6; Male; Mice, Inbred C57BL; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |
Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Imidazoles; Immunohistochemistry; Lipopolysaccharides; Male; Microscopy, Fluorescence; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Protective Agents; Purinergic P2X Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Rosaniline Dyes | 2017 |
Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway.
Topics: Acute Kidney Injury; Adult; Aged; Animals; Case-Control Studies; Cell Line; Disease Models, Animal; Female; Glomerular Filtration Rate; Hepatitis A Virus Cellular Receptor 1; Humans; Imidazoles; Interleukin-6; Macrophage Activation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Middle Aged; Mitogen-Activated Protein Kinases; Pyridines; RAW 264.7 Cells; Recombinant Proteins; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha | 2017 |
Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy.
Topics: Animals; Anisomycin; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Imidazoles; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats, Sprague-Dawley; Signal Transduction | 2017 |
SB203580, a p38 mitogen-activated protein kinase inhibitor, fails to improve functional outcome following a moderate spinal cord injury in rat.
Topics: Activating Transcription Factor 2; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; Male; Motor Activity; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Spinal Cord Injuries; Time Factors | 2008 |
Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat.
Topics: Animals; Burns; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Male; Microglia; Neurons; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Pain; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papillomavirus; Disease Models, Animal; DNA Mutational Analysis; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Rabbits; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Viral Proteins | 2009 |
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Collagen Type II; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Flavonols; Humans; Hypersensitivity, Delayed; Imidazoles; Interleukin-1beta; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Oxazolone; Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Rhus; Synovial Membrane; Vascular Endothelial Growth Factor A | 2009 |
Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertrophy; Imidazoles; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscular Diseases; Myogenin; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Pyridines; Receptors, Notch; Signal Transduction; Testosterone | 2009 |
Inhibition of p38 MAPK reverses hypoxia-induced pulmonary artery endothelial dysfunction.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Imidazoles; Male; Nitric Oxide; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Superoxides; Vasodilation; Vasodilator Agents | 2009 |
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Nerves; Stress, Physiological; Up-Regulation; Viscera; Water Deprivation | 2009 |
Hindlimb unweighting induces changes in the p38MAPK contractile pathway of the rat abdominal aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Hindlimb Suspension; HSP27 Heat-Shock Proteins; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Signal Transduction | 2009 |
[Expression and role of p38 mitogen-activated protein kinase in hyperoxia-induced lung injury juvenile rat model].
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Hyperoxia; Imidazoles; Immunoblotting; Lung Injury; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar | 2009 |
Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anisomycin; Diazoxide; Disease Models, Animal; Electroretinography; Enzyme Activators; Imidazoles; Intraocular Pressure; Ischemia; Ischemic Preconditioning; Mitogen-Activated Protein Kinase 14; Phosphorylation; Potassium Channels; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Reperfusion Injury; Retinal Neurons; Retinal Vessels; RNA Interference; Signal Transduction; Time Factors | 2009 |
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Antioxidants; Blood Pressure; Blood Vessels; Catalase; Cell Respiration; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Homeostasis; Humans; Hydrogen Peroxide; Hypertension; Imidazoles; Ion Channels; Male; Medulla Oblongata; Microinjections; Mitochondria; Mitochondrial Proteins; NADPH Oxidases; Onium Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; PPAR gamma; Pyridines; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Rosiglitazone; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Sympathetic Nervous System; Thiazolidinediones; Time Factors; Transcription Factors; Transcriptional Activation; Transduction, Genetic; Uncoupling Protein 2; Up-Regulation | 2009 |
Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Hypercholesterolemia; Imidazoles; Mesenchymal Stem Cells; Mice; Mice, Knockout; Neovascularization, Physiologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2010 |
[Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease].
Topics: Animals; Anthracenes; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium; Endothelium, Vascular; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Interferon-gamma; Interleukin-6; Mice; Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes; Thromboplastin; Tumor Necrosis Factor-alpha | 2009 |
p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis.
Topics: Adolescent; Adult; Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Disease Models, Animal; Enzyme Inhibitors; Female; Fetal Blood; Flow Cytometry; Humans; Imidazoles; Interleukin-17; Lymph Nodes; Male; Mice; Middle Aged; Mitogen-Activated Protein Kinase 14; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Spleen; Uveitis; Uveomeningoencephalitic Syndrome; Young Adult | 2010 |
Cyclic stretch induces proliferation and TGF-beta1-mediated apoptosis via p38 and ERK in ureteric bud cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Mice; Mice, Transgenic; p38 Mitogen-Activated Protein Kinases; PAX2 Transcription Factor; Pyridines; Signal Transduction; Stress, Mechanical; Time Factors; Transforming Growth Factor beta1; Ureter; Ureteral Obstruction | 2010 |
PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.
Topics: Animals; Animals, Newborn; Anthracenes; Blood Pressure; Carbon Dioxide; Cardiovascular Agents; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hypercapnia; Hypotension; Hypoxia-Ischemia, Brain; Imidazoles; Injections, Intravenous; Isoproterenol; JNK Mitogen-Activated Protein Kinases; Male; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pia Mater; Protein Kinase Inhibitors; Pyridines; Swine; Time Factors; Up-Regulation; Vasodilation; Vasodilator Agents | 2010 |
VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Choline O-Acetyltransferase; Chromones; Cinnamates; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Imidazoles; Infusion Pumps, Implantable; Male; Morpholines; Motor Activity; Motor Neurons; Nerve Degeneration; Neurotoxicity Syndromes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Cerebrovascular Circulation; Disease Models, Animal; Erythrosine; Female; Fibrinolytic Agents; Imidazoles; Intracranial Thrombosis; JNK Mitogen-Activated Protein Kinases; Lasers, Solid-State; Male; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; Swine; Time Factors; Tissue Plasminogen Activator; Vasoconstriction; Vasodilation | 2010 |
Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters.
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Interleukin-1; Serotonin Plasma Membrane Transport Proteins; Synaptosomes | 2010 |
Regulation of tau pathology by the microglial fractalkine receptor.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Count; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; CX3C Chemokine Receptor 1; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Lipopolysaccharides; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Models, Biological; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Chemokine; Receptors, Interleukin-1; Silver Staining; Statistics, Nonparametric; tau Proteins; Tauopathies; Time Factors; Toll-Like Receptor 4 | 2010 |
Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions.
Topics: Action Potentials; Animals; Cyclooxygenase 1; Disease Models, Animal; Dura Mater; Endothelial Cells; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Male; Membrane Proteins; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor, Type I; Sensory Receptor Cells; Time Factors; Trigeminal Ganglion; Tumor Necrosis Factor-alpha | 2011 |
Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase.
Topics: Angiotensin II; Animals; Carotid Arteries; Catalase; Connective Tissue; Disease Models, Animal; Hydrogen Peroxide; Imidazoles; Male; Muscle Relaxation; Myocytes, Smooth Muscle; Myography; p38 Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyridines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vascular Diseases | 2011 |
Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemokine CXCL1; Chemokine CXCL2; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Liver Diseases; Male; Ondansetron; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Rats; Rats, Sprague-Dawley; Resuscitation; Serotonin Antagonists; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha | 2011 |
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.
Topics: Animals; Cell Line; Disease Models, Animal; Heat-Shock Proteins; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Molecular Chaperones; Neoplasm Proteins; Nephrotic Syndrome; p38 Mitogen-Activated Protein Kinases; Podocytes; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Puromycin Aminonucleoside; Pyridines; Serum Albumin; Signal Transduction | 2011 |
Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Deferoxamine; Disease Models, Animal; Enzyme Activation; Humans; Imidazoles; Intramolecular Oxidoreductases; MAP Kinase Signaling System; Melanins; Melanoma; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Pyridines | 2011 |
Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cell Count; Cell Line, Transformed; Cytokines; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Imidazoles; Interleukin-10; Isothiuronium; Lipopolysaccharides; Male; Mice; Microglia; Nitric Oxide Synthase Type II; Pyridines; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha | 2011 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection | 2012 |
Shifts in cell-type expression accompany a diminishing role of spinal p38-mapkinase activation over time during prolonged postoperative pain.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Hyperalgesia; Imidazoles; Immunohistochemistry; Male; Microglia; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain, Postoperative; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Time | 2011 |
Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition.
Topics: Animals; Apoptosis; Cell Differentiation; Disease Models, Animal; Embryonic Stem Cells; Enzyme Activation; Fibroblasts; Heart Ventricles; Humans; Imidazoles; Immunohistochemistry; Injections; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 14; Myocardial Infarction; Myocytes, Cardiac; Pyridines; Teratoma | 2012 |
Inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway attenuates cerebral vasospasm following experimental subarachnoid hemorrhage in rabbits.
Topics: Activating Transcription Factor 2; Animals; Apoptosis; Basilar Artery; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo.
Topics: Animals; Ankylosis; Bone Morphogenetic Proteins; Cell Proliferation; Cells, Cultured; Chondrocytes; Chondrogenesis; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Imidazoles; Male; Mice; Mice, Inbred DBA; p38 Mitogen-Activated Protein Kinases; Periosteum; Pyridines; Signal Transduction; Smad Proteins; Spondylitis, Ankylosing; Transforming Growth Factor beta | 2012 |
Effects of relaxin on relapse and periodontal tissue remodeling after experimental tooth movement in rats.
Topics: Adolescent; Animals; Cell Survival; Cells, Cultured; Collagen Type I; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Periodontal Ligament; Pyridines; Rats; Rats, Wistar; Recurrence; Relaxin; RNA, Messenger; Tooth Migration; X-Ray Microtomography | 2012 |
Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart.
Topics: Animals; Antineoplastic Agents; Butadienes; Cardiomegaly; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; Interleukin-6; Male; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; STAT1 Transcription Factor; STAT3 Transcription Factor; Vidarabine | 2012 |
PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage.
Topics: Animals; Antibodies; Basal Ganglia; Benzamides; Blood Transfusion, Autologous; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Enzyme Inhibitors; Evans Blue; Gene Expression Regulation; Imatinib Mesylate; Imidazoles; Metalloendopeptidases; Mice; p38 Mitogen-Activated Protein Kinases; Piperazines; Pyridines; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Thrombin; Time Factors | 2011 |
Intermittent hypoxia conditioning protects mitochondrial cytochrome c oxidase of rat cerebellum from ethanol withdrawal stress.
Topics: Alcohol Drinking; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Blotting, Western; Cerebellum; Cytochromes c; Disease Models, Animal; Electron Transport Complex IV; Ethanol; Hypoxia; Imidazoles; Male; Mitochondria; Motor Activity; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Carbonylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Spectrophotometry; Substance Withdrawal Syndrome; Time Factors; Vitamin E | 2012 |
Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Cholesterol; Disease Models, Animal; Homeostasis; Humans; Imidazoles; Ketocholesterols; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plaque, Atherosclerotic; Protein Kinase Inhibitors; Pyridines; Squalene Monooxygenase; Time Factors; Up-Regulation | 2012 |
Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.
Topics: Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Analysis of Variance; Animals; Animals, Newborn; Axons; Axotomy; CD11b Antigen; Cells, Cultured; Chemokine CXCL10; Coculture Techniques; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Hippocampus; Humans; Imidazoles; Interferon-beta; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Microarray Analysis; Microfluidic Analytical Techniques; Microglia; Nerve Degeneration; Neurons; Nitric Oxide; Peptides; Phagocytosis; Pyridines; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Time Factors; Transfection | 2012 |
Melanocortin 4 receptor mediates neuropathic pain through p38MAPK in spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Delivery Systems; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hyperalgesia; Imidazoles; Male; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Peptides, Cyclic; Pyridines; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Sciatica; Spinal Cord; Time Factors | 2012 |
Inhibition of p38 MAPK during ischemia, but not reperfusion, effectively attenuates fatal arrhythmia in ischemia/reperfusion heart.
Topics: Administration, Intravenous; Animals; Arrhythmias, Cardiac; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Time Factors; Ventricular Function | 2013 |
Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Enzyme Activation; Ganglia, Spinal; Hyperalgesia; Imidazoles; Male; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; TRPA1 Cation Channel; TRPC Cation Channels; Visceral Pain | 2013 |
Orofacial neuropathic pain mouse model induced by Trigeminal Inflammatory Compression (TIC) of the infraorbital nerve.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Facial Pain; Hyperalgesia; Imidazoles; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Nerve Compression Syndromes; Neuralgia; Neurons; Orbit; p38 Mitogen-Activated Protein Kinases; Purinergic P2X Receptor Antagonists; Pyridines; Tetrazoles; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal | 2012 |
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Hyperalgesia; Imidazoles; Male; Mice; Mice, Inbred ICR; Morpholines; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sciatica; Sigma-1 Receptor; Spinal Cord | 2013 |
Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.
Topics: Animals; Atrophy; Chemokine CCL2; Chemokine CCL7; Disease Models, Animal; Fibrosis; Imidazoles; Kidney; Male; Mice; Mice, Inbred C57BL; Nephrosclerosis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR2; Renal Artery Obstruction; Signal Transduction; Up-Regulation | 2013 |
Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice.
Topics: Animals; bcl-X Protein; Brain Edema; Brain Infarction; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Immunoprecipitation; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Mice; Mice, Inbred BALB C; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Pyridines; Time Factors | 2013 |
Role of p38 mitogen-activated protein kinase in lung injury after burn trauma.
Topics: Animals; Bronchoalveolar Lavage Fluid; Burns; Capillary Permeability; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Interleukin-1; Lung; Lung Injury; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blotting, Western; Brain; Brain Infarction; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Imidazoles; Immunohistochemistry; Infarction, Middle Cerebral Artery; Isoenzymes; Lectins; Male; Microglia; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Neurologic Examination; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Time Factors | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK.
Topics: Animals; Anisomycin; Anthracenes; Cardiac Output; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar | 2003 |
Isoflurane preconditioning induces neuroprotection against ischemia via activation of P38 mitogen-activated protein kinases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Imidazoles; Ischemic Preconditioning; Isoflurane; Male; Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media.
Topics: Acute Disease; Animals; Disease Models, Animal; Ear, Middle; Enzyme Inhibitors; Haemophilus Infections; Haemophilus influenzae; Humans; Hyperplasia; Imidazoles; Male; Mitogen-Activated Protein Kinases; Mucous Membrane; Otitis Media; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley | 2004 |
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease.
Topics: Animals; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Imidazoles; Inflammation Mediators; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plasma Cells; Protein Kinases; Pyridines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction | 2004 |
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
Topics: Animals; Crohn Disease; Cytokines; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Female; Imidazoles; Immunoblotting; Inflammation; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Pyridines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Subcellular Fractions; Trinitrobenzenesulfonic Acid; Up-Regulation | 2005 |
[Protective effect of p38 mitogen activated protein kinase inhibitor on organs in sepsis in rats].
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Interleukin-1beta; Male; Multiple Organ Failure; p38 Mitogen-Activated Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha | 2005 |
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Serine; Time Factors | 2005 |
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Glucagon; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Streptozocin; Trans-Activators; Transcription Factors; Transfection | 2005 |
Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine model.
Topics: Analysis of Variance; Animals; Capillary Permeability; Cells, Cultured; Chemotaxis, Leukocyte; Complement C5a, des-Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Imidazoles; Intubation, Intratracheal; Lung; MAP Kinase Signaling System; Mice; Neutrophils; p38 Mitogen-Activated Protein Kinases; Proteins; Pulmonary Alveoli; Pyridines; Respiratory Distress Syndrome; Time Factors | 2005 |
The effect of PGG-beta-glucan on neutrophil chemotaxis in vivo.
Topics: Animals; beta-Glucans; Cell Movement; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelial Cells; Imidazoles; Leukocytes; Male; Neutrophils; p38 Mitogen-Activated Protein Kinases; Prostaglandins G; Pyridines; Rats; Rats, Inbred F344; Time Factors; Wound Healing | 2006 |
Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Female; Imidazoles; Inflammatory Bowel Diseases; Matrix Metalloproteinase 10; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Pyridines; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.
Topics: Animals; Butadienes; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 14; Neoplasms; Nitriles; Pyridines; Structure-Activity Relationship; Thalidomide; Xenograft Model Antitumor Assays | 2006 |
No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases.
Topics: Adult; Animals; Blotting, Western; Colitis, Ulcerative; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression; Humans; Imidazoles; Inflammatory Bowel Diseases; Interleukin-1; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred BALB C; Middle Aged; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Prognosis; Pyridines; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Imidazoles; Injections, Spinal; Interleukin-1; Interleukin-6; Joints; Matrix Metalloproteinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Inbred Lew; RNA, Messenger; Spinal Cord; Synovial Membrane; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Tumor necrosis factor-alpha induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins.
Topics: Animals; Apolipoprotein B-48; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Insulin Resistance; Intestinal Mucosa; Intestines; Male; Mesocricetus; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Tumor Necrosis Factor; Signal Transduction; Triglycerides; Tumor Necrosis Factor-alpha | 2007 |
Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; alpha-Crystallin B Chain; Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Estradiol; Fluid Therapy; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Imidazoles; Male; Myocardium; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Postoperative Hemorrhage; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Resuscitation; Up-Regulation; Ventricular Function, Left; Ventricular Pressure | 2007 |
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Topics: Acetophenones; Animals; Blood Flow Velocity; Cells, Cultured; Collateral Circulation; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Ditiocarb; Endothelial Cells; Enzyme Inhibitors; Humans; Imidazoles; Ligation; Male; MAP Kinase Signaling System; Myocardial Reperfusion Injury; NADPH Oxidases; Neovascularization, Physiologic; Onium Compounds; Oxygenases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2007 |
Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.
Topics: Animals; Autoimmunity; Catechin; Cell Line; Cell Survival; Disease Models, Animal; Flavonoids; Humans; Imidazoles; Lymphocytes; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mice; Mice, Inbred NOD; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Plant Extracts; Polyphenols; Pyridines; Salivary Glands; Sjogren's Syndrome; Tea; Tumor Necrosis Factor-alpha | 2007 |
Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed intestinal transit in burned rats.
Topics: Animals; Burns; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Transit; Imidazoles; Intestinal Diseases; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiourea | 2007 |
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Burns; Caspase 3; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; I-kappa B Kinase; Imidazoles; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction | 2007 |
Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Body Weight; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Facial Pain; Flavonoids; Functional Laterality; Hyperalgesia; Imidazoles; Male; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Time Factors | 2007 |
Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A.
Topics: Animals; Bacterial Toxins; Colon; Dimerization; Disease Models, Animal; Enterotoxins; Enzyme Activation; Epithelial Cells; Genes, ras; HT29 Cells; Humans; Ileitis; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Time Factors; Transcription Factor AP-1; Transfection | 2007 |
Inhibition of p38 mitogen-activated protein kinase attenuates experimental autoimmune hepatitis: involvement of nuclear factor kappa B.
Topics: Alanine Transaminase; Animals; Autoantigens; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hepatitis, Autoimmune; Imidazoles; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; S100 Proteins; Signal Transduction | 2007 |
Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Ventricular Function, Left | 2007 |
Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27.
Topics: Animals; Blotting, Western; Densitometry; Disease Models, Animal; Dystrophin; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypothermia, Induced; Imidazoles; Insulin; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Tubulin; Ventricular Function, Left | 2008 |
p38 mitogen-activated protein kinase inhibition decreases TNFalpha secretion and protects against left ventricular remodeling in rats with myocardial ischemia.
Topics: Actins; Animals; Blotting, Western; Collagen Type I; Coronary Vessels; Disease Models, Animal; Down-Regulation; Echocardiography; Fibrosis; Imidazoles; Immunohistochemistry; Injections, Intraperitoneal; Ligation; Microscopy, Electron, Transmission; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Ventricular Remodeling | 2008 |
Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK.
Topics: Animals; Antibodies; Cells, Cultured; Chemotaxis; Disease Models, Animal; Heart Ventricles; Imidazoles; Male; Myocardial Infarction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Stem Cell Factor; Stem Cells; Time Factors; Up-Regulation | 2008 |
p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme Activation; I-kappa B Proteins; Imidazoles; Inflammation Mediators; Injections, Intravenous; Interleukin-6; Lipopolysaccharides; Lung; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Organ Size; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function | 2008 |
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Topics: Animals; Arachidonic Acid; Arthritis; Bone Resorption; Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Disease Models, Animal; Enzyme Inhibitors; Female; Imidazoles; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred Lew; Shock, Septic; Tumor Necrosis Factor-alpha | 1996 |
Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage; Cell Movement; Disease Models, Animal; Enzyme Inhibitors; Female; Hypersensitivity; Imidazoles; Mitogen-Activated Protein Kinases; Ovalbumin; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Tumor Necrosis Factor-alpha | 2000 |
p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Female; Humans; Imidazoles; Injections, Intraperitoneal; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pneumonia, Pneumococcal; Pyridines; Tuberculosis; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart.
Topics: Animals; Blotting, Western; Coronary Circulation; Disease Models, Animal; Dogs; Enzyme Activation; Enzyme Inhibitors; Heart; Heat-Shock Proteins; Hemodynamics; Imidazoles; Infusions, Intravenous; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Pyridines; Survival Rate | 2001 |
MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Skin; Stress, Mechanical; Wound Healing | 2002 |