Page last updated: 2024-09-05

sb 203580 and Cardiovascular Stroke

sb 203580 has been researched along with Cardiovascular Stroke in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	20 (64.52)	29.6817
2010's	11 (35.48)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Plowright, AT; Schade, D	1
Liang, T; Liu, M; Lu, L; Wang, ZL; Zhang, PY; Zhang, Q	1
Cha, L; Dai, Y; Han, B; Li, J; Li, X; Mu, J; Shi, Y; Yan, S	1
Hu, X; Jiang, H; Wang, J; Xie, J; Zhou, X	1
Li, G; Qian, W; Zhao, C	1
Avkiran, M; Bassi, R; Clark, JE; Jacquet, S; Kumphune, S; Marber, MS; O'Keefe, SJ; Sicard, P; Verma, S	1
Arthur, JS; Clark, JE; Jacquet, S; Marber, MS; Mohammadi, S; O'Keefe, SJ; Sicard, P	1
Chu, W; Li, B; Li, X; Lu, Y; Shan, H; Wang, B; Yang, B; Zhang, J; Zhang, L; Zhang, Y; Zhao, M	1
Bernstein, HS; Boyle, A; Gaur, M; Prasad, M; Ritner, C; Sievers, RE; Yeghiazarians, Y; Zhang, Y	1
Gan, Y; Kuang, D; Ni, J; She, T; Wang, G; Wang, X; Yue, J; Zhao, X	1
Chattipakorn, N; Chattipakorn, S; Kumphune, S; Surinkaew, S	1
Cohen, MV; Critz, SD; Downey, JM; Qin, Q; Yue, Y	1
Belosjorow, S; Gres, P; Heusch, G; Jansen, J; Michel, MC; Schulz, R	1
Belosjorow, S; Duschin, A; Gres, P; Heusch, G; Konietzka, I; Schulz, R; Skyschally, A	1
Bouchard, JF; Lagneux, C; Lamontagne, D; Lépicier, P	1
Bassi, R; Davis, RJ; Flavell, RA; Gorog, DA; Heads, RJ; Jiang, J; Marber, MS; Martin, JL; Saurin, AT; Tanno, M	1
Genade, S; Hattingh, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA	1
Bellahcene, M; Cao, X; Gorog, DA; Marber, MS; Quinlan, RA; Tanno, M	1
Akamastu, S; Ishisaki, A; Kanno, Y; Kato, K; Kitajima, Y; Kozawa, O; Matsuno, H; Nakajima, K; Shu, E; Suga, H; Takai, S	1
Hartley, S; Lochner, A; Marais, E; Moolman, JA; Van Wyk, J	1
Engel, FB; Hsieh, PC; Keating, MT; Lee, RT	1
Cheng, G; Padbury, JF; Tseng, YT; Zhang, LX; Zhao, TC	1
Aggeli, IK; Beis, I; Gaitanaki, C; Iliodromitis, EK; Kremastinos, DT; Tsiafoutis, I; Zoga, A	1
Feng, Y; Kuang, D; Ni, J; Wang, G; Wu, R; Xiao, G; Zhao, X	1
Clark, JE; Cotten, M; Eickhoff, J; Flavell, RA; Jacquet, S; Kobayashi, KS; Kumphune, S; Marber, MS; Nishino, Y; Sicard, P	1
Boumendjel, A; Carroll, R; Godin-Ribuot, D; Joyeux, M; Ribuot, C; Yellon, DM	1
Aki, T; Asakura, M; Asanuma, H; Fukushima, T; Hatanaka, K; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J; Yoshida, K	1
Cohen, MV; Critz, S; Downey, JM; Nakano, A	1
Baxter, GF; Critz, SD; Mocanu, MM; Yellon, DM; Yue, Y	1
Gysembergh, A; Kloner, RA; Przyklenk, K; Simkhovich, BZ	1
Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J	1

Reviews

1 review(s) available for sb 203580 and Cardiovascular Stroke

Article	Year
Medicinal Chemistry Approaches to Heart Regeneration. Journal of medicinal chemistry, 2015, Dec-24, Volume: 58, Issue:24 Topics: Animals; Cell Differentiation; Cell Proliferation; Cellular Reprogramming; Fibroblasts; Humans; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Pluripotent Stem Cells; Regeneration; Signal Transduction; Stem Cells	2015

Other Studies

30 other study(ies) available for sb 203580 and Cardiovascular Stroke

Article	Year
MAPK pathway regulated the cardiomyocyte apoptosis in mice with post-infarction heart failure. Bratislavske lekarske listy, 2017, Volume: 118, Issue:6 Topics: Animals; Apoptosis; Blotting, Western; Caspase 12; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Fluorescent Antibody Technique; Heart Failure; Heat-Shock Proteins; Hypertrophy, Left Ventricular; Imidazoles; Male; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phosphoproteins; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription Factor CHOP; Up-Regulation	2017
Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia/reperfusion injury following acute myocardial infarction. Biochemical and biophysical research communications, 2017, 09-30, Volume: 491, Issue:4 Topics: Acute Disease; Apoptosis; Cells, Cultured; Down-Regulation; Humans; Imidazoles; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels, Voltage-Gated; Pyridines; RNA, Long Noncoding	2017
[Selectively stimulating β1-adrenergic receptor attenuates rat myocardial ischemia/reperfusion injury in vivo by inhibiting high mobility group box 1 protein release]. Zhonghua xin xue guan bing za zhi, 2014, Volume: 42, Issue:8 Topics: Animals; Chromones; Dobutamine; HMGB1 Protein; Imidazoles; Interleukin-6; Male; Morpholines; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2014
Analyzing the anti-ischemia-reperfusion injury effects of ginsenoside Rb1 mediated through the inhibition of p38α MAPK. Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:1 Topics: Animals; Cardiotonic Agents; Caspase 3; Ginsenosides; Imidazoles; Male; Mitogen-Activated Protein Kinase 14; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	2016
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. The Journal of biological chemistry, 2010, Jan-29, Volume: 285, Issue:5 Topics: Animals; Enzyme Activation; Humans; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Models, Biological; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Tyrosine	2010
The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning. Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:6 Topics: Alleles; Animals; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Myocardial Infarction; Phosphorylation; Protein Isoforms; Pyridines; Time Factors	2010
Tanshinone IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 26, Issue:6 Topics: Abietanes; Animals; Connexin 43; Imidazoles; MicroRNAs; Myocardial Infarction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Serum Response Factor; Signal Transduction	2010
Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition. Cytotherapy, 2012, Volume: 14, Issue:2 Topics: Animals; Apoptosis; Cell Differentiation; Disease Models, Animal; Embryonic Stem Cells; Enzyme Activation; Fibroblasts; Heart Ventricles; Humans; Imidazoles; Immunohistochemistry; Injections; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 14; Myocardial Infarction; Myocytes, Cardiac; Pyridines; Teratoma	2012
Hyperglycemia suppresses cardiac stem cell homing to peri-infarcted myocardium via regulation of ERK1/2 and p38 MAPK activities. International journal of molecular medicine, 2012, Volume: 30, Issue:6 Topics: Animals; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimental; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Hyperglycemia; Imidazoles; Male; MAP Kinase Signaling System; Myocardial Infarction; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats; Rats, Sprague-Dawley; Stem Cell Factor; Stem Cells; Ventricular Pressure	2012
Inhibition of p38 MAPK during ischemia, but not reperfusion, effectively attenuates fatal arrhythmia in ischemia/reperfusion heart. Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:2 Topics: Administration, Intravenous; Animals; Arrhythmias, Cardiac; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Time Factors; Ventricular Function	2013
The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart. Cardiovascular research, 2002, Aug-15, Volume: 55, Issue:3 Topics: Animals; Anisomycin; Decanoic Acids; Diazoxide; Enzyme Activators; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Hydroxy Acids; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Perfusion; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tiopronin; Vitamin K 3	2002
p38 MAP kinase is a mediator of ischemic preconditioning in pigs. Cardiovascular research, 2002, Aug-15, Volume: 55, Issue:3 Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardium; Organic Chemicals; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Swine, Miniature; Time Factors	2002
Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:10 Topics: Animals; Connexin 43; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Kinetics; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Models, Biological; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Pyridines; Swine	2003
Endocannabinoids protect the rat isolated heart against ischaemia. British journal of pharmacology, 2003, Volume: 139, Issue:4 Topics: Amides; Animals; Arachidonic Acids; Biomarkers; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Endocannabinoids; Ethanolamines; Glycerides; Heart; Imidazoles; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Piperidines; Protein Kinase C; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction	2003
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circulation research, 2003, Aug-08, Volume: 93, Issue:3 Topics: Animals; Carrier Proteins; Cells, Cultured; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Kinase 3; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myoblasts; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha	2003
Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK. Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:3 Topics: Animals; Anisomycin; Anthracenes; Cardiac Output; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar	2003
Tumor necrosis factor-induced protection of the murine heart is independent of p38-MAPK activation. Journal of molecular and cellular cardiology, 2003, Volume: 35, Issue:12 Topics: Animals; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Time Factors; Tumor Necrosis Factor-alpha	2003
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB. Archives of biochemistry and biophysics, 2005, Jun-15, Volume: 438, Issue:2 Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Serine; Time Factors	2005
Inhibition of myocardial apoptosis by ischaemic and beta-adrenergic preconditioning is dependent on p38 MAPK. Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:1 Topics: Adrenergic beta-Agonists; Animals; Anisomycin; Apoptosis; Enzyme Activators; Imidazoles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isoproterenol; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats	2006
FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America, 2006, Oct-17, Volume: 103, Issue:42 Topics: Animals; Cicatrix; Enzyme Inhibitors; Fibroblast Growth Factor 1; Imidazoles; Male; Mitosis; Myocardial Infarction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Regeneration	2006
Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. Cardiovascular research, 2007, Dec-01, Volume: 76, Issue:3 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Ventricular Function, Left	2007
p38-MAPK is involved in restoration of the lost protection of preconditioning by nicorandil in vivo. European journal of pharmacology, 2008, Jan-28, Volume: 579, Issue:1-3 Topics: Animals; Anti-Arrhythmia Agents; Cyclic GMP; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Nicorandil; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium Channels; Protein Kinase C; Pyridines; Rabbits; Signal Transduction	2008
Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Basic research in cardiology, 2008, Volume: 103, Issue:3 Topics: Animals; Antibodies; Cells, Cultured; Chemotaxis; Disease Models, Animal; Heart Ventricles; Imidazoles; Male; Myocardial Infarction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Stem Cell Factor; Stem Cells; Time Factors; Up-Regulation	2008
The role of RIP2 in p38 MAPK activation in the stressed heart. The Journal of biological chemistry, 2008, May-02, Volume: 283, Issue:18 Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Cells, Cultured; Enzyme Activation; Imidazoles; In Vitro Techniques; Male; Mice; Myocardial Contraction; Myocardial Infarction; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Pyridines; Pyrimidines; Rats; Receptor-Interacting Protein Serine-Threonine Kinase 2	2008
SB 203580, a mitogen-activated protein kinase inhibitor, abolishes resistance to myocardial infarction induced by heat stress. Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:3 Topics: Animals; Blotting, Western; Enzyme Inhibitors; Heat Stress Disorders; Heat-Shock Proteins; Hemodynamics; HSP72 Heat-Shock Proteins; Imidazoles; Mitogen-Activated Protein Kinases; Myocardial Infarction; Pyridines; Rats; Reperfusion Injury; Ventricular Function, Left	2000
Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart. Circulation research, 2001, Feb-02, Volume: 88, Issue:2 Topics: Animals; Blotting, Western; Coronary Circulation; Disease Models, Animal; Dogs; Enzyme Activation; Enzyme Inhibitors; Heart; Heat-Shock Proteins; Hemodynamics; Imidazoles; Infusions, Intravenous; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Pyridines; Survival Rate	2001
SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts. Basic research in cardiology, 2000, Volume: 95, Issue:6 Topics: Animals; Coronary Circulation; Enzyme Inhibitors; Heart; Imidazoles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Pressure; Pyridines; Rabbits; Ventricular Function, Left	2000
The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical. Basic research in cardiology, 2000, Volume: 95, Issue:6 Topics: Animals; Coronary Circulation; Drug Administration Schedule; Enzyme Inhibitors; Heart; Imidazoles; In Vitro Techniques; Ischemic Preconditioning; Male; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Ventricular Function, Left	2000
p38 MAPK activity is not increased early during sustained coronary artery occlusion in preconditioned versus control rabbit heart. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:4 Topics: Animals; Coronary Artery Disease; Enzyme Inhibitors; Heart; Imidazoles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits; Time Factors	2001
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. Circulation, 2001, Aug-07, Volume: 104, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Flow Velocity; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cardiovascular Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Enzyme Inhibitors; Flavonoids; Hemodynamics; Imidazoles; Indoles; Isoquinolines; Maleimides; Milrinone; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Protein Kinase C; Pyridines; Pyridones; Sulfonamides; Ventricular Fibrillation	2001