Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and Cancer of Liver

sb 203580 has been researched along with Cancer of Liver in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's8 (33.33)29.6817
2010's11 (45.83)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
He, H; Jia, Y; Peng, L; Qiao, K; Wang, C; Xu, Z; Yang, W; Zhang, C; Zhang, Z1
Dong, J; Hu, A; Jiang, L; Liang, Y; Sun, C; Tian, B; Wang, H; Wang, S1
Chen, J; Chen, X; Chu, L; Ding, Z; Guo, T; Hou, R; Huang, Z; Liang, H; Liang, J; Liao, J; Liu, S; Song, S; Tan, X; Wang, Y; Wen, J; Wu, Y; Yang, C; Zhang, B; Zhang, J; Zhang, Z1
Bai, X; Bao, Y; Li, H; Li, X; Liu, L; Suvesh, M; Xu, D1
Gui, S; Huang, D; Liu, H; Shao, D; Wang, Y; Wei, W; Zhang, L; Zhou, Q1
Rui, X; Yan, X; Zhang, K1
Liu, X; Lv, Y; Shi, J; Xiang, J; Zhang, X1
Jian, KL; Kong, LY; Shang, ZC; Yang, L; Zhang, C1
Kim, JR; Lee, KH1
Huang, SM; Kim, J; Kim, JM; Kim, NS; Kim, SU; Lee, DS; Oh, NS; Song, IS; Yu, DY1
Lee, WY; Liu, KW; Yeung, JH1
Sun, S; Tang, Y; Wang, F; Wang, Y; Yang, F; Yin, Y; Zhang, L1
Bai, ST; Chen, WC; Chung, JG; Huang, CH; Huang, LJ; Hung, CM; Kuo, SC; Tsai, JY; Way, TD1
Qian, ZY; Qiu, JW; Shen, LJ; Yu, J; Zhang, HX1
Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C1
Anwar-Mohamed, A; Denison, MS; El-Kadi, AO; Korashy, HM; Soshilov, AA1
Chen, GG; Chun, S; Lai, PB; Leung, BC; Zhang, H; Zhang, Z1
Chen, X; Duan, L; He, T; Luo, J; Shi, Q; Tang, M; Wang, H; Weng, Y; Wu, R; Yang, X; Ye, L; Zhang, Y; Zhou, L1
Roberts, RA1
Bronk, SF; Gores, GJ; Guicciardi, ME; Werneburg, NW1
Kaneoka, Y; Kozawa, O; Kumada, T; Matsushima-Nishiwaki, R; Takai, S; Tokuda, H; Toyoda, H; Yamaguchi, A; Yasuda, E1
Lou, L; Quan, H; Xu, Y1
Ben-Levy, R; Krupsky, M; Zauberman, A; Zipori, D1
Dokter, WH; Jonk, LJ; Kruijer, W; Schuringa, JJ; Vellenga, E1

Reviews

1 review(s) available for sb 203580 and Cancer of Liver

ArticleYear
Evidence for cross talk between PPARalpha and p38 MAP kinase.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 68, Issue:2

    Topics: Animals; Carcinogens; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Hepatocytes; Imidazoles; Liver Neoplasms; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Pyridines; Rats; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors

2002

Other Studies

23 other study(ies) available for sb 203580 and Cancer of Liver

ArticleYear
Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway.
    Clinical and translational science, 2021, Volume: 14, Issue:5

    Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Curcumin; Hep G2 Cells; Humans; Hydrazines; Imidazoles; Liver Neoplasms; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Toxicity Tests, Subacute; Xenograft Model Antitumor Assays

2021
ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma.
    International journal of oncology, 2020, Volume: 57, Issue:1

    Topics: ADAM17 Protein; Adult; Aged; Animals; Bone Marrow; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CX3CL1; Endothelial Progenitor Cells; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Imidazoles; Liver Neoplasms; Male; Mice; Middle Aged; Mitogen-Activated Protein Kinase 14; Pyridines; Receptors, CXCR3; RNA, Small Interfering; Signal Transduction; Spinal Neoplasms; Spine; Tumor Microenvironment

2020
H19 Promotes HCC Bone Metastasis Through Reducing Osteoprotegerin Expression in a Protein Phosphatase 1 Catalytic Subunit Alpha/p38 Mitogen-Activated Protein Kinase-Dependent Manner and Sponging microRNA 200b-3p.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:1

    Topics: Animals; Bone Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Imidazoles; Liver Neoplasms; Male; Mice; MicroRNAs; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Protein Phosphatase 1; Pyridines; RAW 264.7 Cells; RNA, Long Noncoding; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1

2021
Ebp1 p48 promotes oncogenic properties in hepatocellular carcinoma through p38 MAPK/HIF1α activation and p53 downregulation.
    Molecular carcinogenesis, 2021, Volume: 60, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Neoplasm Transplantation; p38 Mitogen-Activated Protein Kinases; Protein Isoforms; Pyridines; RNA-Binding Proteins; Survival Analysis; Tissue Array Analysis; Tumor Suppressor Protein p53

2021
Fenretinide inhibits the proliferation and migration of human liver cancer HepG2 cells by downregulating the activation of myosin light chain kinase through the p38‑MAPK signaling pathway.
    Oncology reports, 2018, Volume: 40, Issue:1

    Topics: Apoptosis; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fenretinide; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Liver Neoplasms; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction

2018
Curcumin inhibits the proliferation and invasiveness of MHCC97-H cells via p38 signaling pathway.
    Drug development research, 2014, Volume: 75, Issue:7

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Curcumin; Drug Synergism; Humans; Imidazoles; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phosphorylation; Pyridines

2014
Overexpression of syntenin enhances hepatoma cell proliferation and invasion: potential roles in human hepatoma.
    Oncology reports, 2014, Volume: 32, Issue:6

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Liver Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Small Interfering; Signal Transduction; Syntenins

2014
Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Feb-15, Volume: 25

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Enzyme Inhibitors; Eucalyptus; Hep G2 Cells; Humans; Imidazoles; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Pyridines; Reactive Oxygen Species

2017
Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor.
    Experimental & molecular medicine, 2009, Mar-31, Volume: 41, Issue:3

    Topics: Cell Line, Tumor; Fluorescent Dyes; Hepatocyte Growth Factor; Humans; Hydrogen Peroxide; Imidazoles; Liver Neoplasms; Mitogen-Activated Protein Kinases; Pyridines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Recombinant Proteins; Urokinase-Type Plasminogen Activator

2009
Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells.
    Carcinogenesis, 2009, Volume: 30, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Imidazoles; Liver Neoplasms; NADPH Oxidase 4; NADPH Oxidases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Peroxiredoxins; Pyridines; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand

2009
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
    Cancer letters, 2009, Nov-18, Volume: 285, Issue:1

    Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors

2009
miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:5

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; E2F1 Transcription Factor; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Liver Neoplasms; MicroRNAs; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 2C; Pyridines; RNA, Small Interfering

2010
Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells.
    Oncology reports, 2010, Volume: 24, Issue:5

    Topics: Animals; Apoptosis; Carbolines; Carcinoma, Hepatocellular; Caspases; Cell Growth Processes; Cell Line, Tumor; Humans; Imidazoles; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Up-Regulation; Xenograft Model Antitumor Assays

2010
[Role of p38MAPK in apoptosis of human paratumor cirrhosis hepatocellular cell line QSG-7701 induced by cisplatin].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:12

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cisplatin; Humans; Imidazoles; Liver Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines

2010
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
    European journal of pharmacology, 2011, Mar-11, Volume: 654, Issue:3

    Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species

2011
The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation.
    Chemical research in toxicology, 2011, Sep-19, Volume: 24, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Cytochrome P-450 CYP1A1; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guinea Pigs; Hep G2 Cells; Humans; Imidazoles; Liver Neoplasms; Male; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Aryl Hydrocarbon; Transcriptional Activation

2011
Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK.
    Apoptosis : an international journal on programmed cell death, 2012, Volume: 17, Issue:4

    Topics: AMP-Activated Protein Kinases; Apoptosis Regulatory Proteins; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Death-Associated Protein Kinases; Enzyme Inhibitors; Humans; Imidazoles; Liver Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines

2012
S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
    International journal of oncology, 2013, Volume: 42, Issue:3

    Topics: Animals; Calgranulin B; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Hep G2 Cells; Humans; Imidazoles; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Transplantation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Random Allocation; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays

2013
cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:5

    Topics: Apoptosis; Butadienes; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Cathepsins; Cell Line, Tumor; Flavonoids; Humans; Imidazoles; Liver Neoplasms; Lysosomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Permeability; Protein Transport; Pyridines; TNF-Related Apoptosis-Inducing Ligand

2007
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
    Life sciences, 2007, Jul-26, Volume: 81, Issue:7

    Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Heat-Shock Proteins; Humans; Imidazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-delta; Pyridines; RNA, Small Interfering; Tetradecanoylphorbol Acetate

2007
p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
    International journal of cancer, 2008, Apr-15, Volume: 122, Issue:8

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Imidazoles; Liver Neoplasms; Male; Microtubules; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines; Stilbenes; Time Factors

2008
Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3.
    Oncogene, 1999, Jul-01, Volume: 18, Issue:26

    Topics: Acute-Phase Proteins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, Reporter; Haptoglobins; HL-60 Cells; Humans; Imidazoles; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Mice; Mitogen-Activated Protein Kinases; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Recombinant Fusion Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured

1999
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.
    The Biochemical journal, 2000, Apr-01, Volume: 347 Pt 1

    Topics: Amino Acid Substitution; Carcinoma, Hepatocellular; Cell Cycle Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Genes, Reporter; Humans; Imidazoles; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Pyridines; rac GTP-Binding Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2000