sb 203580 has been researched along with Breast Neoplasms in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (45.95) | 29.6817 |
| 2010's | 18 (48.65) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Ghani, TM; Ali, HI; Amin, KM; Anwar, MM; Serry, AM; Syam, YM | 2 |
| Abd Elmageed, ZY; Abdel Latif, NA; Abdelhafez, OM; Ahmed, EY; Ali, HI; Arafa, RK | 1 |
| Chang, A; Cheng, D; Huang, S; Liu, AT; Sun, P; Tan, X; Wang, G; Wang, J; Wang, Q; Wu, D; Xiang, R; Yang, S; Zhao, S | 1 |
| Collazo, J; Friedman, T; Hikim, AS; Jimenez, T; Pervin, S; Singh, R; Singh, V; Sinha, S; Tucker, A; Vadgama, J | 1 |
| Chen, HQ; Deng, ZL; Jiang, X; Li, H; Liu, Y; Tian, DD; Wang, Y; Yuan, W; Zhang, RX | 1 |
| Hu, Z; Lai, W; Li, R; Ma, Y; Shi, F; Yue, C; Zhao, M | 1 |
| Gui, S; Wang, B; Wang, Y; Yan, Y; Zhou, J; Zhou, Q | 1 |
| Hsu, A; Kumar, AP; Sethi, G; Tan, KH; Woo, CC | 1 |
| Fan, WJ; Rao, SM; Song, GH; Song, JL; Yang, XG; Yuan, L | 1 |
| Chen, Q; Song, J; Wei, Y; Xing, D | 1 |
| Bang, SI; Cheon, S; Cho, D; Jung, MK; Kim, D; Kim, HJ; Park, H; Song, SB; Yang, Y | 1 |
| Chang, H; Kim, A; Kim, H; Kim, J; Kong, J | 1 |
| de Lima, ME; Goes, AM; Gravina, HD; Huth, HW; Resende, JM; Ropert, C; Santos, DM | 1 |
| Agnello, M; Casano, C; Luparello, C; Sirchia, R | 1 |
| Cui, W; Hu, JL; Xiao, L | 1 |
| Brown, PH; Chen, L; Hilsenbeck, SG; Krisko, TI; Mayer, JA; Speers, CW; Wang, T | 1 |
| Carraro, F; Filippi, I; Giavazzi, R; Miglietta, D; Moschetta, M; Naldini, A | 1 |
| Han, X; Han, YC; Li, BL; Li, ZQ; Mi, XY; Song, M; Sun, LM; Wang, EH; Wang, R; Zhao, Y | 1 |
| Chandramouli, A; Cress, AE; King, T; Nelson, MA; Okun, A; Porreca, F; Sukhtankar, D; Vanderah, TW | 1 |
| Graham, K; Lanza-Jacoby, S; Yan, G | 1 |
| Chen, H; Fang, ZP; Kung, HF; Lin, MC; Min, DL; Shen, Z; Tang, LN; Yao, Y; Yu, WX; Yue, L | 1 |
| Boldt, S; Kolch, W; Weidle, UH | 1 |
| Dittmer, J; Lindemann, RK; Nordheim, A | 1 |
| Brinckerhoff, CE; Coon, CI; Tower, GB | 1 |
| Blaschke, F; Bruemmer, D; Herle, AJ; Hsueh, WA; Law, RE; Yin, F | 1 |
| Itoh, K; Lin, M; van Golen, KL; Yee, D; Yoshioka, K; Zhang, X | 1 |
| Chakraborty, C; Lala, PK; Timoshenko, AV; Wagner, GF | 1 |
| Han, YC; Li, BL; Song, M; Wang, R; Zeng, XX; Zhao, Y | 1 |
| Shapiro, DJ; Zhang, CC | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Okajima, E; Thorgeirsson, UP | 1 |
| Han, J; Huang, S; Nemerow, GR; New, L; Pan, Z | 1 |
| Creminon, C; Hla, T; Huang, CK; Jang, BC; Liu, CH; Sanchez, T; Schaefers, HJ; Trifan, OC | 1 |
| Bacus, SS; Gudkov, AV; Keyomarsi, K; Komarov, AP; Lowe, M; Lyass, L; Seger, R; Yarden, Y; Yung, Y | 1 |
| Grijalva, R; Klos, K; Li, P; Nguyen, N; Xiong, S; Yao, J; Yu, D | 1 |
| Chen, G; DeLuca, HF; Han, J; Maitra, RK; Pramanik, R; Qi, X; Schultz, RM; Wang, J | 1 |
37 other study(ies) available for sb 203580 and Breast Neoplasms
| Article | Year |
|---|---|
Synthesis and molecular docking studies of new furochromone derivatives as p38α MAPK inhibitors targeting human breast cancer MCF-7 cells.
Topics: Apoptosis; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Catalytic Domain; Cell Cycle Checkpoints; Chromones; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Molecular Docking Simulation; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization | 2017 |
Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds.
Topics: Antineoplastic Agents; Apoptosis; Biological Products; Breast Neoplasms; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; MCF-7 Cells; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Structure; Oxygen; Protein Kinase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dipeptides; Female; Heat-Shock Proteins; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 14; Molecular Chaperones; Neoplasm Metastasis; Phosphorylation; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; Pyridines; Receptor, ErbB-2; Xenograft Model Antitumor Assays | 2020 |
Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Female; Humans; Imidazoles; Inflammasomes; Inflammation; Mammary Neoplasms, Animal; Mecamylamine; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Nicotine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Up-Regulation | 2020 |
Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38α MAP kinase inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Breast Neoplasms; Caspase 3; Caspase 9; Catalytic Domain; Chromones; Doxorubicin; G2 Phase Cell Cycle Checkpoints; Humans; Imidazoles; MCF-7 Cells; Mitogen-Activated Protein Kinase 14; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines | 2018 |
Knockdown of Bone Morphogenetic Proteins Type 1a Receptor (BMPR1a) in Breast Cancer Cells Protects Bone from Breast Cancer-Induced Osteolysis by Suppressing RANKL Expression.
Topics: Animals; Bone and Bones; Bone Marrow Cells; Bone Morphogenetic Protein Receptors, Type I; Breast Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; Down-Regulation; Female; Humans; Imidazoles; MCF-7 Cells; Mice; Mice, Nude; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; RAW 264.7 Cells; RNA Interference; Signal Transduction; Tibia | 2018 |
Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Glycoproteins; Microfilament Proteins; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines | 2019 |
A novel all-trans retinoid acid derivatives inhibits the migration of breast cancer cell lines MDA-MB-231 via myosin light chain kinase involving p38-MAPK pathway.
Topics: Antineoplastic Agents; Azepines; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Inhibitory Concentration 50; Myosin-Light-Chain Kinase; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Retinoids; Tretinoin | 2013 |
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Silencing; Humans; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2013 |
[Inhibitory effect of exogenous insulin-like growth factor binding protein 7 on proliferation of human breast cancer cell line MDA-MB-453 and its mechanism].
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Female; Humans; Imidazoles; Insulin-Like Growth Factor Binding Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Somatomedins | 2013 |
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Female; Humans; Imidazoles; Interleukin-1beta; Light; MCF-7 Cells; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Pyridines; Reactive Oxygen Species; Signal Transduction; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2014 |
Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Claudin-1; Claudin-3; Claudin-4; Claudins; Down-Regulation; Female; Flavonoids; Gene Knockdown Techniques; Humans; Imidazoles; Interleukin-18; MAP Kinase Signaling System; MCF-7 Cells; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; RNA, Small Interfering; Tight Junctions | 2015 |
EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells.
Topics: Breast Neoplasms; Cadherins; Cell Movement; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; Female; Fibronectins; Humans; Imidazoles; MCF-7 Cells; Molecular Targeted Therapy; Phosphorylation; Pyridines; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad3 Protein; Snail Family Transcription Factors; Vimentin | 2016 |
Upregulation of p38 pathway accelerates proliferation and migration of MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Signaling System; Peptides; Phosphorylation; Pyridines; Spider Venoms; Up-Regulation | 2017 |
Cadmium effects on p38/MAPK isoforms in MDA-MB231 breast cancer cells.
Topics: Breast Neoplasms; Cadmium; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Isoenzymes; p38 Mitogen-Activated Protein Kinases; Pyridines; Structure-Activity Relationship; Transcriptional Activation; Tumor Cells, Cultured | 2010 |
[Study of the relationship between early growth response gene 1 activity in p38 mitogen-activated protein kinase pathway and epirubicin resistance of human breast carcinoma cells].
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Early Growth Response Protein 1; Enzyme Inhibitors; Epirubicin; Female; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction | 2009 |
Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Female; Gene Silencing; Humans; Imidazoles; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Protein Phosphatase 2C; Pyridines; Receptors, Estrogen; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53 | 2009 |
Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α.
Topics: Animals; Breast Neoplasms; Cell Communication; Cell Movement; Enzyme Inhibitors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Interleukin-1beta; Interleukin-8; Mice; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasm Transplantation; Pyridines; Transplantation, Heterologous | 2010 |
Integrin β3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Cell Survival; Chi-Square Distribution; Enzyme Inhibitors; Female; Formazans; Humans; Imidazoles; Immunohistochemistry; Integrin beta3; Middle Aged; p38 Mitogen-Activated Protein Kinases; Pyridines; Retrospective Studies; Tenascin; Tetrazolium Salts; Urokinase-Type Plasminogen Activator | 2010 |
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.
Topics: Animals; Bone Remodeling; Breast Neoplasms; Cell Line, Tumor; Female; Femur; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Pain Management; Pyridines; Signal Transduction | 2011 |
Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Curcumin; Cyclin D1; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines | 2013 |
HGFK1 inhibits bone metastasis in breast cancer through the TAK1/p38 MAPK signaling pathway.
Topics: Adult; Aged; Animals; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dependovirus; Drug Screening Assays, Antitumor; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genetic Therapy; Genetic Vectors; Hepatocyte Growth Factor; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Kringles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases; Pyridines; Real-Time Polymerase Chain Reaction; Receptor Activator of Nuclear Factor-kappa B | 2012 |
The role of MAPK pathways in the action of chemotherapeutic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Ceramides; Enzyme Activation; Enzyme Inhibitors; Etoposide; Female; Flavonoids; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Microtubules; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Pyridines; Skin Neoplasms; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smad3 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta | 2003 |
The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.
Topics: Binding Sites; Breast Neoplasms; Cell Line, Tumor; Collagen Type I; Down-Regulation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; In Vitro Techniques; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2003 |
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cell Cycle; Chromans; Enzyme Inhibitors; Female; Flavonoids; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteins; Pyridines; RNA, Small Interfering; Signal Transduction; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2004 |
Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration.
Topics: Amides; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Female; Focal Adhesion Kinase 1; Humans; Imidazoles; Immunoblotting; Insulin-Like Growth Factor I; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Pyridines; rho GTP-Binding Proteins; Signal Transduction | 2005 |
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; Enzyme Activation; Female; Glycoproteins; Humans; Imidazoles; Lymphangiogenesis; Molecular Sequence Data; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; RNA, Small Interfering; Structure-Activity Relationship; Vascular Endothelial Growth Factor C; Vesicular Transport Proteins | 2006 |
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer].
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Disease-Free Survival; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Follow-Up Studies; Humans; Imidazoles; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Urokinase-Type Plasminogen Activator | 2007 |
Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis.
Topics: Apoptosis; Breast Neoplasms; Cell Transformation, Neoplastic; Enzyme Induction; Estradiol; Female; HeLa Cells; Humans; Imidazoles; MAP Kinase Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Receptors, Estrogen; Recombinant Proteins; Tamoxifen | 2000 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Line; Cell Transformation, Neoplastic; Endothelial Growth Factors; Epithelial Cells; Flavonoids; Genes, myc; Genes, ras; Imidazoles; Liver; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Oncogene Proteins v-raf; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Extracellular Matrix; Female; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2000 |
Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Dominant; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; Flavonoids; G2 Phase; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Protein Serine-Threonine Kinases; Pyridines; Rats; Receptor, ErbB-2; Retinoblastoma Protein; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Invasiveness; Neuregulin-1; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; RNA, Neoplasm; Signal Transduction; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cholecalciferol; Female; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Calcitriol; Transcription Factor AP-1; Transcriptional Activation; Tumor Cells, Cultured | 2002 |