sb 203580 has been researched along with Arthritis, Rheumatoid in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Belfield, AJ; Brown, DS; Brown, GR; Campbell, D; Foubister, A; Masters, DJ; Pike, KG; Snelson, WL; Wells, SL | 1 |
| Jiang, Y; Mu, F; Wu, H; You, Q; Zhang, N | 1 |
| Bai, C; Chai, L; Deng, P; Jia, Y; Li, J; Liu, C; Sun, Q; Zhao, X; Zheng, C | 1 |
| Chen, KL; Li, XF; Luo, J; Niu, HQ; Qin, KL; Zhao, WP; Zhao, XC | 1 |
| Chen, Y; Dai, SM; He, ZW; Qin, YH; Shen, Q; Wang, ZW | 1 |
| Choi, DY; Huh, JE; Jeon, G; Lee, JD; Park, DS; Woo, HS; Yang, HR | 1 |
| Brown, A; Foxwell, BM; Page, TH; Ray, KP; Timms, EM | 1 |
| Julovi, SM; Nakagawa, T; Nakamura, T; Shimizu, M; Yasuda, T | 1 |
| Cho, ML; Kim, HY; Kim, KW; Lee, SH; Park, MK; Park, SH; Yoon, CH | 1 |
| Han, SK; Jeon, SJ; Miyazawa, K; Yi, SY; Yoo, YS | 1 |
| Albani, S; Boyle, DL; Firestein, GS; Hammaker, D; Jones, TL; Rosengren, S; Sorkin, L; Svensson, CI | 1 |
| Fuhrmann, R; Gandesiri, M; Kinne, RW; Kunisch, E; Roth, A; Winter, R | 1 |
| Ajisawa, Y; Akahane, M; Miyata, H; Miyazawa, K; Mori, A; Okudaira, H | 1 |
| Miyazawa, K; Mori, A; Okudaira, H | 1 |
| Aupperle, KR; Bennett, B; Boyle, DL; Firestein, GS; Han, Z; Manning, AM | 1 |
| Kobayashi, M; Matsui, N; Okamoto, T; Suzuki, M; Tetsuka, T; Watanabe, N; Yoshida, S | 1 |
| Brinckerhoff, CE; Vincenti, MP | 1 |
| Klein, JP; Neff, L; Schöller-Guinard, M; Sibilia, J; Wachsmann, D; Zeisel, M | 1 |
18 other study(ies) available for sb 203580 and Arthritis, Rheumatoid
| Article | Year |
|---|---|
A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.
Topics: Amides; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Rats; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway.
Topics: Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Iridoid Glucosides; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; RNA, Messenger; Signal Transduction; Sulfones; Synoviocytes; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2019 |
Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis.
Topics: Animals; Anisomycin; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Collagen; Female; Imidazoles; Inflammation; Lipoxins; MAP Kinase Signaling System; Mice; Mice, Inbred DBA; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Synovial Membrane | 2021 |
Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclophosphamide; Drug Therapy, Combination; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Interleukin-6; Janus Kinase 2; Methotrexate; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor; Synoviocytes; Tyrphostins | 2018 |
HMGB1 acts in synergy with lipopolysaccharide in activating rheumatoid synovial fibroblasts via p38 MAPK and NF-κB signaling pathways.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cell Proliferation; Fibroblasts; Gene Expression Regulation; HMGB1 Protein; Humans; Imidazoles; Interleukin-6; Lipopolysaccharides; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Middle Aged; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Signal Transduction; Sulfones; Synovial Membrane; Toll-Like Receptor 4 | 2013 |
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Collagen Type II; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Flavonols; Humans; Hypersensitivity, Delayed; Imidazoles; Interleukin-1beta; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Oxazolone; Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Rhus; Synovial Membrane; Vascular Endothelial Growth Factor A | 2009 |
Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: does variable inhibition of interleukin-6 production limit effectiveness in vivo?
Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Interleukin-6; Macrophages; Monocytes; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazoles; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane | 2010 |
Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Carrier Proteins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Integrin alpha4; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Pyridines; Synovial Membrane | 2003 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
Enhancement of anti-inflammatory tendency by SB203580, p38alpha specific inhibitor, in human fibroblast-like synoviocyte cell line, MH7A.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Line; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase 14; Phosphorylation; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Synovial Membrane | 2006 |
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Imidazoles; Injections, Spinal; Interleukin-1; Interleukin-6; Joints; Matrix Metalloproteinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Inbred Lew; RNA, Messenger; Spinal Cord; Synovial Membrane; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Blotting, Western; Butadienes; Case-Control Studies; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase 4; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Nitriles; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Statistics, Nonparametric; Synovial Membrane; Tumor Necrosis Factor-alpha | 2007 |
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Synovial Membrane | 1998 |
Establishment and characterization of a novel human rheumatoid fibroblast-like synoviocyte line, MH7A, immortalized with SV40 T antigen.
Topics: Antigens, Polyomavirus Transforming; Antigens, Surface; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Dexamethasone; Fibroblasts; Flavonoids; Growth Substances; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Receptors, Interleukin-1; Synovial Membrane; Transfection | 1998 |
Jun N-terminal kinase in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Collagenases; Enzyme Inhibitors; Extracellular Matrix; Gene Expression; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Synovial Membrane; Time Factors; Transcription Factor AP-1 | 1999 |
The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha | 2000 |
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Collagenases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction | 2001 |
NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.
Topics: Anti-Bacterial Agents; Apigenin; Arthritis, Rheumatoid; Bacterial Proteins; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Membrane Glycoproteins; NF-kappa B; Pyridines; Signal Transduction; Streptococcus; Sulfasalazine; Synovial Membrane | 2001 |