Page last updated: 2024-11-04

sb 202190 and Retinoblastoma

sb 202190 has been researched along with Retinoblastoma in 1 studies

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase

Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

Research Excerpts

ExcerptRelevanceReference
" We found that SB 202190 (10muM) inhibits retinoblastoma protein (pRb) phosphorylation, in response to S/K deprivation."3.75The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein. ( Camins, A; Folch, J; Pallàs, M; Yeste-Velasco, M, 2009)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yeste-Velasco, M1
Folch, J1
Pallàs, M1
Camins, A1

Other Studies

1 other study available for sb 202190 and Retinoblastoma

ArticleYear
The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein.
    Neurochemistry international, 2009, Volume: 54, Issue:2

    Topics: Animals; Apoptosis; Cell Count; Cell Cycle; Cell Nucleus; Cell Survival; Cells, Cultured; DNA Fragme

2009