sb 202190 has been researched along with Myocardial Ischemia in 6 studies
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrosis was assessed after 40 min of ischemia and 2 h of reperfusion using 2,3,5-triphenyltetrazolium chloride (TTC) staining and creatine kinase release." | 1.31 | Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning. ( Chen, W; Hou, J; Murphy, E; Schneider, S; Steenbergen, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clanachan, AS | 3 |
| Jaswal, JS | 3 |
| Gandhi, M | 3 |
| Bottorff, DA | 1 |
| Coughlin, J | 1 |
| Finegan, BA | 3 |
| Stone, JC | 1 |
| Ritchie, RH | 1 |
| Gordon, JM | 1 |
| Woodman, OL | 1 |
| Cao, AH | 1 |
| Dusting, GJ | 1 |
| Dyck, JR | 2 |
| Schneider, S | 1 |
| Chen, W | 1 |
| Hou, J | 1 |
| Steenbergen, C | 1 |
| Murphy, E | 1 |
| Moor, AN | 1 |
| Gan, XT | 1 |
| Karmazyn, M | 1 |
| Fliegel, L | 1 |
6 other studies available for sb 202190 and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.
Topics: Animals; Enzyme Activation; Flavonoids; Hypothermia, Induced; Imidazoles; Male; Mitogen-Activated Pr | 2003 |
Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.
Topics: Alkaloids; Analysis of Variance; Animals; Annexin A1; Benzophenanthridines; Cells, Cultured; Creatin | 2005 |
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Coronary Circulation; Enzyme Inhibitors; Glucose; | 2007 |
Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Disease Models, Animal; Gluco | 2007 |
Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning.
Topics: Animals; Enzyme Inhibitors; Glycolysis; Heart Rate; Hydrogen-Ion Concentration; Imidazoles; Ischemic | 2001 |
Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heart; Heart Ventricles; | 2001 |