sb 202190 has been researched along with Hypertrophy in 4 studies
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evidence suggests that the arachidonic acid metabolite of 12-lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), not only mediates the effects of angiotensin II (AngII), but also has direct effects on hypertrophy and matrix protein production in vascular smooth muscle cells (VSMCs)." | 7.71 | The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II ( Fatima, S; Lanting, L; Nadler, JL; Natarajan, R; Reddy, MA; Thimmalapura, PR, 2002) |
| "Evidence suggests that the arachidonic acid metabolite of 12-lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), not only mediates the effects of angiotensin II (AngII), but also has direct effects on hypertrophy and matrix protein production in vascular smooth muscle cells (VSMCs)." | 3.71 | The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II ( Fatima, S; Lanting, L; Nadler, JL; Natarajan, R; Reddy, MA; Thimmalapura, PR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kinugawa, K | 1 |
| Jeong, MY | 1 |
| Bristow, MR | 1 |
| Long, CS | 1 |
| Zhou, L | 1 |
| Goldsmith, AM | 1 |
| Bentley, JK | 1 |
| Jia, Y | 1 |
| Rodriguez, ML | 1 |
| Abe, MK | 1 |
| Fingar, DC | 1 |
| Hershenson, MB | 1 |
| Wenzel, S | 1 |
| Rohde, C | 1 |
| Wingerning, S | 1 |
| Roth, J | 1 |
| Kojda, G | 1 |
| Schlüter, KD | 1 |
| Reddy, MA | 1 |
| Thimmalapura, PR | 1 |
| Lanting, L | 1 |
| Nadler, JL | 1 |
| Fatima, S | 1 |
| Natarajan, R | 1 |
4 other studies available for sb 202190 and Hypertrophy
| Article | Year |
|---|---|
Thyroid hormone induces cardiac myocyte hypertrophy in a thyroid hormone receptor alpha1-specific manner that requires TAK1 and p38 mitogen-activated protein kinase.
Topics: Adenoviridae; Animals; Blotting, Western; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cytosol | 2005 |
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Topics: Adaptor Proteins, Signal Transducing; Bronchi; Carrier Proteins; Cell Cycle Proteins; Cell Enlargeme | 2005 |
Lack of endothelial nitric oxide synthase-derived nitric oxide formation favors hypertrophy in adult ventricular cardiomyocytes.
Topics: Animals; Cells, Cultured; Cytokines; Enzyme Activation; Enzyme Inhibitors; Heart Ventricles; Hypertr | 2007 |
The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Angiotensin II; Animals; Cell Nucleus; Cells, Cultured; | 2002 |