sb 202190 has been researched along with Disease Models, Animal in 19 studies
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia." | 7.77 | Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. ( Feng, AW; Li, JS; Li, N; Li, QR; Mao, Q; Yu, C, 2011) |
| "The aim of this study is to explore the effects of SB 202190, a highly selective p38 MAPK inhibitor, on bleb survival following glaucoma filtering surgery." | 3.81 | A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery. ( Grisanti, S; Lüke, J; Lüke, M; Nassar, K; Tura, A, 2015) |
| "The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia." | 3.77 | Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. ( Feng, AW; Li, JS; Li, N; Li, QR; Mao, Q; Yu, C, 2011) |
| "In four of ten rats, seizure frequency was unaltered by LEV (non-responders)." | 1.42 | Blockade of endothelin B receptor improves the efficacy of levetiracetam in chronic epileptic rats. ( Kang, TC; Ko, AR, 2015) |
| "Each peptide evoked dose-dependent thermal hyperalgesia that required activation of the mitogen-activated protein kinase p38." | 1.35 | Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. ( Anderson, LB; Braun, PD; Fairbanks, CA; Honda, CN; Kitto, KF; Riedl, MS; Roiko, SA; Vulchanova, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Semwal, BC | 1 |
| Garabadu, D | 1 |
| Li, P | 1 |
| Li, X | 1 |
| Deng, P | 1 |
| Wang, D | 1 |
| Bai, X | 1 |
| Li, Y | 1 |
| Luo, C | 1 |
| Belguise, K | 1 |
| Wang, X | 1 |
| Wei, X | 1 |
| Xia, Z | 1 |
| Yi, B | 1 |
| Yang, S | 1 |
| Zhou, G | 1 |
| Liu, H | 1 |
| Zhang, B | 1 |
| Li, J | 1 |
| Cui, R | 1 |
| Du, Y | 1 |
| Nassar, K | 1 |
| Tura, A | 1 |
| Lüke, J | 1 |
| Lüke, M | 1 |
| Grisanti, S | 2 |
| Ko, AR | 1 |
| Kang, TC | 2 |
| Monteleone, I | 1 |
| Marafini, I | 1 |
| Dinallo, V | 1 |
| Di Fusco, D | 1 |
| Troncone, E | 1 |
| Zorzi, F | 1 |
| Laudisi, F | 1 |
| Monteleone, G | 1 |
| Kim, DS | 1 |
| Min, SJ | 1 |
| Kim, MJ | 1 |
| Kim, JE | 1 |
| O'Sullivan, A | 1 |
| O'Malley, D | 1 |
| Coffey, J | 1 |
| Wang, JH | 1 |
| Redmond, H | 1 |
| Riedl, MS | 1 |
| Braun, PD | 1 |
| Kitto, KF | 1 |
| Roiko, SA | 1 |
| Anderson, LB | 1 |
| Honda, CN | 1 |
| Fairbanks, CA | 1 |
| Vulchanova, L | 1 |
| Lilleholt, LL | 1 |
| Johansen, C | 1 |
| Arthur, JS | 1 |
| Funding, A | 1 |
| Bibby, BM | 1 |
| Kragballe, K | 1 |
| Iversen, L | 1 |
| Feng, AW | 1 |
| Yu, C | 1 |
| Mao, Q | 1 |
| Li, N | 1 |
| Li, QR | 1 |
| Li, JS | 1 |
| Pavao-de-Souza, GF | 1 |
| Zarpelon, AC | 1 |
| Tedeschi, GC | 1 |
| Mizokami, SS | 1 |
| Sanson, JS | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Takanami-Ohnishi, Y | 1 |
| Amano, S | 1 |
| Kimura, S | 1 |
| Asada, S | 1 |
| Utani, A | 1 |
| Maruyama, M | 1 |
| Osada, H | 1 |
| Tsunoda, H | 1 |
| Irukayama-Tomobe, Y | 1 |
| Goto, K | 1 |
| Karin, M | 1 |
| Sudo, T | 1 |
| Kasuya, Y | 1 |
| Choudhury, BK | 1 |
| Wild, JS | 1 |
| Alam, R | 1 |
| Klinman, DM | 1 |
| Boldogh, I | 1 |
| Dharajiya, N | 1 |
| Mileski, WJ | 1 |
| Sur, S | 1 |
| Saika, S | 1 |
| Yamanaka, O | 1 |
| Ikeda, K | 1 |
| Kim-Mitsuyama, S | 1 |
| Flanders, KC | 1 |
| Yoo, J | 1 |
| Roberts, AB | 1 |
| Nishikawa-Ishida, I | 1 |
| Ohnishi, Y | 1 |
| Muragaki, Y | 1 |
| Ooshima, A | 1 |
| Jaswal, JS | 1 |
| Gandhi, M | 1 |
| Finegan, BA | 1 |
| Dyck, JR | 1 |
| Clanachan, AS | 1 |
| Studer, RK | 1 |
| Gilbertson, LG | 1 |
| Georgescu, H | 1 |
| Sowa, G | 1 |
| Vo, N | 1 |
| Kang, JD | 1 |
19 other studies available for sb 202190 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
5-N-ethyl Carboxamidoadenosine Stimulates Adenosine-2b Receptor-Mediated Mitogen-Activated Protein Kinase Pathway to Improve Brain Mitochondrial Function in Amyloid Beta-Induced Cognitive Deficit Mice.
Topics: Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Alzheimer Disease; Amyloid beta-P | 2020 |
Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats.
Topics: Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Brain; Brain Injuries; C | 2020 |
Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia.
Topics: Animals; Apoptosis; Caspase 3; Dementia, Vascular; Disease Models, Animal; Gene Expression Regulatio | 2013 |
A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibito | 2015 |
Blockade of endothelin B receptor improves the efficacy of levetiracetam in chronic epileptic rats.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Disease Models, Animal; Endothelin B Receptor Anta | 2015 |
Sodium chloride-enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice.
Topics: Animals; Colitis; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Interleukin-17; Intestinal | 2017 |
Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, U | 2016 |
Inhibition of nuclear factor-kappaB and p38 mitogen-activated protein kinase does not always have adverse effects on wound healing.
Topics: Animals; Cytokines; Disease Models, Animal; Histocytochemistry; Humans; Imidazoles; Immunosuppressiv | 2010 |
Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
Topics: Animals; Benzoxazoles; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; En | 2009 |
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Dermatitis; Disease Models, Animal; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; F | 2011 |
Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.
Topics: Acute Disease; Anilides; Animals; Anti-Inflammatory Agents; Berberine; Coptis; Cyclooxygenase 2; Cyc | 2011 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids | 2012 |
Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.
Topics: Allergens; Animals; Base Sequence; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal | 2002 |
In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cells, Cultured; C | 2002 |
Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Collagen Type I; Disease Models, Animal; Enzy | 2005 |
Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Disease Models, Animal; Gluco | 2007 |
p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1.
Topics: Animals; Cells, Cultured; Cytokines; Dinoprostone; Disease Models, Animal; Gene Expression; Imidazol | 2008 |