sb 202190 has been researched along with Colorectal Neoplasms in 7 studies
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite new agent development and short-term benefits in patients with colorectal cancer (CRC), metastatic CRC cure rates have not improved due to high rates of 5-fluorouracil (5-FU)/leucovorin/oxaliplatin (FOLFOX)-resistance and a clinical therapeutic plateau." | 7.91 | ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. ( Amin, S; Jaiswal, AS; Law, BK; Narayan, S; Ramisetti, S; Sharma, AK; Singh, P; Singh-Pillay, A, 2019) |
| "Despite new agent development and short-term benefits in patients with colorectal cancer (CRC), metastatic CRC cure rates have not improved due to high rates of 5-fluorouracil (5-FU)/leucovorin/oxaliplatin (FOLFOX)-resistance and a clinical therapeutic plateau." | 3.91 | ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. ( Amin, S; Jaiswal, AS; Law, BK; Narayan, S; Ramisetti, S; Sharma, AK; Singh, P; Singh-Pillay, A, 2019) |
| "However, the growth of some colorectal cancer (CRC)-derived organoid cultures is inhibited by this molecule via an unknown mechanism." | 1.91 | SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation. ( Benelli, R; Coco, S; Costa, D; Grillo, F; Longo, L; Mastracci, L; Poggi, A; Scabini, S; Tosetti, F; Venè, R, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Narayan, S | 1 |
| Ramisetti, S | 1 |
| Jaiswal, AS | 1 |
| Law, BK | 1 |
| Singh-Pillay, A | 1 |
| Singh, P | 1 |
| Amin, S | 1 |
| Sharma, AK | 1 |
| Costa, D | 1 |
| Venè, R | 1 |
| Coco, S | 1 |
| Longo, L | 1 |
| Tosetti, F | 1 |
| Scabini, S | 1 |
| Mastracci, L | 1 |
| Grillo, F | 1 |
| Poggi, A | 1 |
| Benelli, R | 1 |
| O'Connell, CE | 1 |
| Vassilev, A | 1 |
| Chiacchiera, F | 2 |
| Matrone, A | 1 |
| Ferrari, E | 1 |
| Ingravallo, G | 2 |
| Lo Sasso, G | 1 |
| Murzilli, S | 3 |
| Petruzzelli, M | 1 |
| Salvatore, L | 1 |
| Moschetta, A | 1 |
| Simone, C | 3 |
| Grossi, V | 2 |
| Cappellari, M | 1 |
| Peserico, A | 1 |
| Simonatto, M | 1 |
| Germani, A | 1 |
| Russo, S | 1 |
| Moyer, MP | 1 |
| Resta, N | 1 |
| Liuzzi, M | 1 |
| Martelli, N | 1 |
| Napoli, A | 1 |
| Del Rio, A | 1 |
| Chiu, SJ | 1 |
| Chao, JI | 1 |
| Lee, YJ | 1 |
| Hsu, TS | 1 |
7 other studies available for sb 202190 and Colorectal Neoplasms
| Article | Year |
|---|---|
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
Topics: Adamantane; Antineoplastic Agents; Aza Compounds; Cell Proliferation; Cell Survival; Colorectal Neop | 2019 |
SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation.
Topics: Colorectal Neoplasms; ErbB Receptors; Humans; Mutation; Organoids; Protein Kinase Inhibitors; Proto- | 2023 |
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells.
Topics: Animals; Apoptosis; Autophagy; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; Gene Expres | 2021 |
p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kin | 2009 |
Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Benzamides; Caspase 8; Cell Death; Cell Line, Tumor; Co | 2012 |
Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Colorectal Neoplasms; Drug Synergism; Female; Human | 2012 |
Regulation of gamma-H2AX and securin contribute to apoptosis by oxaliplatin via a p38 mitogen-activated protein kinase-dependent pathway in human colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase Inhibitors; Colorectal Neoplasms; Dose- | 2008 |