sb 202190 has been researched along with Carcinoma, Hepatocellular in 5 studies
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings demonstrated the potential of genipin in suppressing hepatocellular carcinoma metastasis, and p38/TIMP-1/MMP-2 pathway may be involved as the key mechanism of its anti-metastasis effect." | 7.78 | Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma. ( Feng, Y; Man, K; Tsao, SW; Wang, N; Zhang, Z; Zhu, M, 2012) |
| "Our findings demonstrated the potential of genipin in suppressing hepatocellular carcinoma metastasis, and p38/TIMP-1/MMP-2 pathway may be involved as the key mechanism of its anti-metastasis effect." | 3.78 | Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma. ( Feng, Y; Man, K; Tsao, SW; Wang, N; Zhang, Z; Zhu, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Refolo, MG | 1 |
| D'Alessandro, R | 1 |
| Lippolis, C | 1 |
| Messa, C | 1 |
| Carella, N | 1 |
| Cavallini, A | 1 |
| Carr, BI | 1 |
| Wang, N | 1 |
| Zhu, M | 1 |
| Tsao, SW | 1 |
| Man, K | 1 |
| Zhang, Z | 1 |
| Feng, Y | 1 |
| Burlando, B | 1 |
| Magnelli, V | 1 |
| Panfoli, I | 1 |
| Berti, E | 1 |
| Viarengo, A | 1 |
| Quan, H | 1 |
| Xu, Y | 1 |
| Lou, L | 1 |
| Bode, JG | 1 |
| Ludwig, S | 1 |
| Freitas, CA | 1 |
| Schaper, F | 1 |
| Ruhl, M | 1 |
| Melmed, S | 1 |
| Heinrich, PC | 1 |
| Häussinger, D | 1 |
5 other studies available for sb 202190 and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Modulation of Doxorubicin mediated growth inhibition of hepatocellular carcinoma cells by platelet lysates.
Topics: Antibiotics, Antineoplastic; Apoptosis; Autophagy; Blood Platelets; Carcinoma, Hepatocellular; Cell | 2014 |
Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cholagogues and Choleretics; Do | 2012 |
Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cop | 2003 |
p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Hepatocell | 2008 |
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; DNA-Binding Proteins; Enzym | 2001 |