saxitoxinol and Neuroblastoma

saxitoxinol has been researched along with Neuroblastoma* in 1 studies

Other Studies

1 other study(ies) available for saxitoxinol and Neuroblastoma

Article	Year
Comparative binding and toxicity of saxitoxin and saxitoxinol in mice and in cultured cells. Biochemistry and molecular biology international, 1997, Volume: 41, Issue:2 The binding characteristics of saxitoxin (STX), a known voltage-gated sodium channel blocker, and its analog saxitoxinol (STXOL), were studied in neuroblastoma, peritoneal macrophage, hepatocytes and PC-12 cell lines. 3H-STXOL bound to the cell-surface sites which appear to be the same as those occupied by 3H-STX and which can, therefore, be identified as STX receptors. The relative agreement of respective Kd obtained by saturation, competition, association and dissociation kinetics for STX and STXOL suggest the absence of any artifact in binding measurements. Unlike STX, STXOL was non-toxic to mice by intratracheal instillation. The major advantage of using 3H-STXOL is that the tritium label is not exchangeable. Data from this study suggest that 3H-STXOL can be used to identify STX receptors at 37 degrees C. Topics: Animals; Binding Sites; Cells, Cultured; Drug Stability; Kinetics; Liver; Macrophages, Peritoneal; Mice; Neuroblastoma; PC12 Cells; Rats; Saxitoxin; Tritium	1997

Article

Year

Comparative binding and toxicity of saxitoxin and saxitoxinol in mice and in cultured cells.

Biochemistry and molecular biology international, 1997, Volume: 41, Issue:2

The binding characteristics of saxitoxin (STX), a known voltage-gated sodium channel blocker, and its analog saxitoxinol (STXOL), were studied in neuroblastoma, peritoneal macrophage, hepatocytes and PC-12 cell lines. 3H-STXOL bound to the cell-surface sites which appear to be the same as those occupied by 3H-STX and which can, therefore, be identified as STX receptors. The relative agreement of respective Kd obtained by saturation, competition, association and dissociation kinetics for STX and STXOL suggest the absence of any artifact in binding measurements. Unlike STX, STXOL was non-toxic to mice by intratracheal instillation. The major advantage of using 3H-STXOL is that the tritium label is not exchangeable. Data from this study suggest that 3H-STXOL can be used to identify STX receptors at 37 degrees C.

Topics: Animals; Binding Sites; Cells, Cultured; Drug Stability; Kinetics; Liver; Macrophages, Peritoneal; Mice; Neuroblastoma; PC12 Cells; Rats; Saxitoxin; Tritium

1997