sauvagine and Melanoma

sauvagine has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for sauvagine and Melanoma

Article	Year
Effect of CRF and related peptides on calcium signaling in human and rodent melanoma cells. FEBS letters, 1998, Sep-18, Volume: 435, Issue:2-3 Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose-dependent increase in the intracellular Ca2+ in both human and hamster melanoma cells. This effect is inhibited by depletion of extracellular calcium using 3 mM EGTA and is attenuated by the CRF receptor antagonist, alpha-helical-CRF(9-41). Other peptides of the CRF superfamily, sauvagine and urocortin, also induce increases in cytoplasmic calcium concentration but at higher concentrations than CRF. We conclude that malignant melanocytes express CRF receptors, which are coupled to activation of plasma membrane calcium channels. Topics: Amphibian Proteins; Animals; Calcium; Corticotropin-Releasing Hormone; Cricetinae; Dose-Response Relationship, Drug; Humans; Melanoma; Peptide Hormones; Peptides; Signal Transduction; Tumor Cells, Cultured; Urocortins; Vasodilator Agents	1998

Article

Year

Effect of CRF and related peptides on calcium signaling in human and rodent melanoma cells.

FEBS letters, 1998, Sep-18, Volume: 435, Issue:2-3

Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose-dependent increase in the intracellular Ca2+ in both human and hamster melanoma cells. This effect is inhibited by depletion of extracellular calcium using 3 mM EGTA and is attenuated by the CRF receptor antagonist, alpha-helical-CRF(9-41). Other peptides of the CRF superfamily, sauvagine and urocortin, also induce increases in cytoplasmic calcium concentration but at higher concentrations than CRF. We conclude that malignant melanocytes express CRF receptors, which are coupled to activation of plasma membrane calcium channels.

Topics: Amphibian Proteins; Animals; Calcium; Corticotropin-Releasing Hormone; Cricetinae; Dose-Response Relationship, Drug; Humans; Melanoma; Peptide Hormones; Peptides; Signal Transduction; Tumor Cells, Cultured; Urocortins; Vasodilator Agents

1998