saussureamine-c and HIV-Infections

saussureamine-c has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for saussureamine-c and HIV-Infections

ArticleYear
Lead screening for CXCR4 of the human HIV infection receptor inhibited by traditional Chinese medicine.
    BioMed research international, 2014, Volume: 2014

    The acquired immunodeficiency syndrome (AIDS) is a serious worldwide disease caused by the human immunodeficiency virus (HIV) infection. Recent research has pointed out that the G protein-coupled chemokine receptor CXCR4 and the coreceptor C-C chemokine receptor type 5 (CCR5) are important targets for HIV infection. The traditional Chinese medicine (TCM) database has been screened for candidate compounds by simulating molecular docking and molecular dynamics against HIV. Saussureamine C, 5-hydroxy-L-tryptophan, and diiodotyrosine are selected based on the highest docking score. The molecular dynamics is helpful in the analysis and detection of protein-ligand interactions. According to the analysis of docking poses, hydrophobic interactions, hydrogen bond variations, and the comparison of the effect on CXCR4 and CCR5, these results indicate Saussureamine C may have better effect on these two receptors. But for some considerations, diiodotyrosine could make the largest variation and may have some efficacy contrary to expectations.

    Topics: Asparagine; HIV Infections; HIV-1; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Medicine, Chinese Traditional; Molecular Docking Simulation; Molecular Dynamics Simulation; Receptors, CCR5; Receptors, CXCR4; Receptors, HIV

2014