saringosterol and Atherosclerosis

Dysregulation of cholesterol homeostasis is a major risk factor of atherosclerosis, which can lead to serious health problems, including heart attack and stroke. Liver X receptor (LXR) α and β are transcription factors belonging to the nuclear receptor superfamily, which play important roles in cholesterol homeostasis. Selectively activating LXRβ provides a promising strategy for the treatment of atherosclerosis. Here, we employed atherosclerotic apoE-knockout mice to evaluate the effects of saringosterol, a phytosterol with potent and selective action for LXRβ, which we identified previously in edible marine seaweed

Topics: Animals; Atherosclerosis; Cholesterol; Cytochrome P-450 Enzyme System; Diet, High-Fat; Hypolipidemic Agents; Intestinal Mucosa; Lipid Metabolism; Liver; Macrophages; Membrane Transport Proteins; Mice, Knockout, ApoE; Sargassum; Stigmasterol