sarin has been researched along with Organophosphorus Poisoning in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (39.53) | 18.7374 |
| 1990's | 15 (17.44) | 18.2507 |
| 2000's | 14 (16.28) | 29.6817 |
| 2010's | 16 (18.60) | 24.3611 |
| 2020's | 7 (8.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kalisiak, J; Kovarik, Z; Maček Hrvat, N; Radić, Z; Sharpless, KB; Šinko, G; Taylor, P | 1 |
| Escher, B; Job, L; Köhler, A; Skerra, A; Worek, F | 1 |
| Amend, N; Niessen, KV; Seeger, T; Thiermann, H; Wille, T; Worek, F | 1 |
| Gore, A | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM | 1 |
| Capacio, BR; Koplovitz, I; Oyler, BL; Shih, TM | 1 |
| Andrýs, R; Karasová, JŽ; Kassa, J; Klusoňová, A; Lísa, M | 1 |
| Box, K; Ceckova, M; Dolezal, R; Gorecki, L; Hepnarova, V; Hrabinova, M; Jankockova, J; Jost, P; Jun, D; Kobrlova, T; Korabecny, J; Kuca, K; Malinak, D; Musilek, K; Nepovimova, E; Nguyen, TD; Outhwaite, B; Pavek, P; Pham, NL; Psotka, M; Sorf, A; Soukup, O | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL | 1 |
| Bangera, N; Doyle-Eisele, M; Garcia, E; Gigliotti, A; Hamilton, DA; Laney, J; Lewine, JD; Magcalas, C; McDonald, JD; Paulson, K; Raulli, R; Weber, W | 1 |
| Marquart, K; Martignoni, ME; Prokopchuk, O; Thiermann, H; Wilhelm, D; Wille, T; Worek, F | 1 |
| Emmett, SR; Haslam, JD; Hulse, EJ; Woolley, T | 1 |
| Płusa, T; Sokołowski, R | 1 |
| Bajgar, J; Cabal, J; Kassa, J; Pavlík, M | 1 |
| Cadieux, CL; Cerasoli, D; Koenig, JA; Koh, J; McDonough, J; Shih, TM; Wang, H; Zhang, Y | 1 |
| Chambers, HW; Chambers, JE; Funck, KE; Meek, EC; Pringle, RB; Ross, MK | 1 |
| Droste, DJ; Gearhart, JM; Kempisty, DM; Shelley, ML | 1 |
| Akkerman, M; Albuquerque, EX; Alkondon, M; Aracava, Y; Merchenthaler, I; Pereira, EF | 1 |
| Cashman, JR; Kalisiak, J; Ralph, EC; Zhang, J | 1 |
| Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW | 1 |
| Bird, M; Chad, JE; Green, AC; Price, M; Tattersall, JE; Timperley, CM; Turner, SR | 1 |
| Liu, J; Yao, Y; Zhan, CG | 1 |
| Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R | 1 |
| Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG | 1 |
| Bueters, TJ; Danhof, M; Groen, B; IJzerman, AP; Van Helden, HP | 1 |
| Rotenberg, JS | 1 |
| ADIE, PA | 1 |
| DULTZ, L; EPSTEIN, MA; FREEMAN, G; GRAY, EH; WEIL, WB | 1 |
| ASKEW, BM | 1 |
| BROWN, RV; KUNKEL, AM; SOMERS, LM; WILLS, JH | 1 |
| COOPER, PL; KRACKOW, EH; OWENS, EJ; PUNTE, CL | 1 |
| FREEMAN, G; GOLD, AJ; JOHNSON, RP | 1 |
| DAVIES, DR; GREEN, AL; WILLEY, GL | 1 |
| FREDRIKSSON, T | 1 |
| GOFFART, J; POCHET, A | 1 |
| LOOMIS, TA; MILLER, GT; WELSH, MJ | 1 |
| LOOMIS, TA; SALAFSKY, B | 1 |
| ADIE, PA; FUKUYAMA, GS; HUGHES, ER | 1 |
| BANNARD, RA; COLEMAN, IW; LITTLE, PE | 1 |
| Newmark, J | 2 |
| Abou-Donia, MB | 1 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA | 1 |
| Kellar, KJ | 1 |
| Abraham, S; Cohen, G; Dachir, S; Gilat, E; Herskovitz, M; Kapon, J; Levy, A; Raveh, L; Teitelbaum, Z | 1 |
| Johnston, A; Rice, P | 1 |
| Antonijevic, B; Stojiljkovic, MP | 1 |
| Germanchuk, VG; Kadushkin, AM; Mandych, VG; Zabrodskii, PF | 1 |
| Hrobak, PK | 1 |
| Hopff, WH; Riggio, G; Waser, PG | 1 |
| Clement, JG; Filbert, M | 1 |
| Hänninen, O; Kaliste-Korhonen, E; Raushel, FM; Tuovinen, K | 1 |
| Clement, JG | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Morita, H | 1 |
| Bajgar, J; Kassa, J | 1 |
| Belkin, M; Solberg, Y | 1 |
| Holstege, CP; Kirk, M; Sidell, FR | 1 |
| Ishøj, T; Jensen, K | 1 |
| Abraham, S; Kadar, T; Oz, N; Sahar, R | 1 |
| Green, DM; Inch, TD; Muir, AW; Stratton, JA | 1 |
| Gordon, JJ; Leadbeater, L | 1 |
| Bartels, PH; Burchfiel, JL; Duffy, FH; Gaon, M; Sim, VM | 1 |
| Bosković, B | 1 |
| Benschop, HP; Berends, F; De Jong, LP; Kepner, LA; Kientz, CE; Meeter, E; Van den Berg, GR; Van Hooidonk, C; Visser, RP | 1 |
| Dasheiff, RM; Einberg, E; Grenell, RG | 1 |
| Bajgar, J; Hrdina, V; Jakl, A; Patocka, J | 1 |
| Boulet, CA; Clement, JG; Hansen, AS | 1 |
| Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR | 1 |
| Broomfield, CA; Castro, CA; Finger, AV; Lenz, DE; Maxwell, DM; Solana, RP | 1 |
| Liu, WF | 1 |
| Baraka, A | 1 |
| Bright, JE; Inns, RH; Marrs, TC; Tuckwell, NJ | 1 |
| Albuquerque, EX; Aracava, Y; Boyne, AF; Deshpande, SS; Idriss, M; Kawabuchi, M; Rickett, DL | 1 |
| Clement, JG; Shiloff, JD | 1 |
| Drewes, LR; Singh, AK | 1 |
| Pantelić, D | 1 |
| Albuquerque, EX; Deshpande, SS; Kauffman, FC; Rickett, DL; Viana, GB | 1 |
| Rengstorff, RH | 1 |
| Green, MD; Hilmas, DE; Jones, DE | 1 |
| Inns, RH; Leadbeater, L; Rylands, JM | 1 |
| Heath, C; Preston, E | 1 |
| Oldiges, H; Schoene, K | 1 |
| Baigar, J; Girdiná, V; Yákl, A | 1 |
| Bajgar, J; Hrdina, V; Jakl, A | 1 |
14 review(s) available for sarin and Organophosphorus Poisoning
| Article | Year |
|---|---|
Diagnostics and treatment of nerve agent poisoning-current status and future developments.
Topics: Antidotes; Cholinesterase Reactivators; Humans; Nerve Agents; Organophosphate Poisoning; Oximes; Sarin; United Kingdom | 2020 |
Broad Spectrum Treatment for Ocular Insult Induced by Organophosphate Chemical Warfare Agents.
Topics: Animals; Atropine; Chemical Warfare Agents; Eye; Nerve Agents; Organophosphate Poisoning; Organophosphates; Sarin | 2020 |
Organophosphorus nerve agent poisoning: managing the poisoned patient.
Topics: Chemical Warfare Agents; Decontamination; Humans; Nerve Agents; Organophosphate Poisoning; Sarin | 2019 |
[Today's threat of use of organophosphorus compounds].
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Exposure; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2015 |
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
A review of nerve agent exposure for the critical care physician.
Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 2002 |
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Organophosphorus ester-induced chronic neurotoxicity.
Topics: Acetylcholinesterase; Acute Disease; Apoptosis; Brain; Chronic Disease; Esters; Humans; Necrosis; Neurodegenerative Diseases; Neurons; Neurotoxicity Syndromes; Organophosphate Poisoning; Organophosphorus Compounds; Oxidative Stress; Prognosis; Risk Factors; Sarin | 2003 |
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime | 2007 |
[Neurotoxicity of nerve agents].
Topics: Acetylcholinesterase; Adult; Cholinesterase Reactivators; Humans; Male; Nervous System; Organophosphate Poisoning; Organophosphorus Compounds; Peripheral Nervous System; Poisoning; Pralidoxime Compounds; Sarin | 1995 |
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission | 1997 |
Chemical warfare. Nerve agent poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 1997 |
[Chemical warfare poisoning in time of peace].
Topics: Chemical Warfare Agents; Decontamination; Denmark; Disaster Planning; Gas Poisoning; Humans; Japan; Mustard Gas; Organophosphate Poisoning; Sarin; Violence | 1999 |
Chemical warfare--the nerve gases.
Topics: Antidotes; Chemical Warfare Agents; Gas Poisoning; Humans; Organophosphate Poisoning; Organophosphates; Protective Clothing; Sarin; Soman | 1991 |
72 other study(ies) available for sarin and Organophosphorus Poisoning
| Article | Year |
|---|---|
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; GPI-Linked Proteins; Humans; Kinetics; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Protein Conformation; Sarin; Structure-Activity Relationship | 2020 |
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Topics: Antidotes; Bacterial Proteins; Caulobacteraceae; Drug Stability; Enzyme Stability; Hot Temperature; Mutation; Nerve Agents; Organophosphate Poisoning; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidation-Reduction; Phosphoric Triester Hydrolases; Protein Denaturation; Recombinant Proteins; Sarin; Soman | 2020 |
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors | 2020 |
The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Guinea Pigs; Male; Microdialysis; Organophosphate Poisoning; Oximes; Permeability; Pralidoxime Compounds; Sarin; Tissue Distribution | 2021 |
Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.
Topics: Acetylcholinesterase; Animals; Area Under Curve; Blood-Brain Barrier; Bridged-Ring Compounds; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Carriers; Enzyme Assays; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Mass Spectrometry; Mice; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Sarin | 2021 |
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Topics: Animals; Antidotes; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Computer Simulation; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Paraoxon; Rats; Sarin | 2018 |
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors | 2018 |
Addition of ketamine to standard-of-care countermeasures for acute organophosphate poisoning improves neurobiological outcomes.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Combined Modality Therapy; Electroencephalography; Excitatory Amino Acid Antagonists; Ketamine; Male; Maze Learning; Organophosphate Poisoning; Rats; Rats, Inbred F344; Sarin; Standard of Care; Treatment Outcome | 2018 |
Human small bowel as model for poisoning with organophosphorus compounds.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Female; Humans; Intestine, Small; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Organophosphate Poisoning; Sarin; Young Adult | 2019 |
Natural Detoxification Capacity to Inactivate Nerve Agents Sarin and VX in the Rat Blood.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterases; Female; Inactivation, Metabolic; Organophosphate Poisoning; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin | 2015 |
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Oximes; Phenols; Pralidoxime Compounds; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2016 |
Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.
Topics: Acetylcholinesterase; Animals; Brain; Cattle; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridines; Rats; Rats, Sprague-Dawley; Sarin; Tandem Mass Spectrometry | 2016 |
A systems dynamics approach to the efficacy of oxime therapy for mild exposure to sarin gas.
Topics: Antidotes; Centers for Disease Control and Prevention, U.S.; Chemical Warfare Agents; Humans; Models, Theoretical; Organophosphate Poisoning; Oximes; Practice Guidelines as Topic; Pralidoxime Compounds; Sarin; Systems Analysis; United States | 2016 |
Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Female; Galantamine; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Nerve Degeneration; Organ Culture Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman; Treatment Outcome | 2010 |
Amidine-oximes: reactivators for organophosphate exposure.
Topics: Acetylcholinesterase; Amidines; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Enzyme Reactivators; Female; Humans; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Permeability; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2011 |
Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.
Topics: Animals; Cell Line, Tumor; Chemical Warfare Agents; Diaphragm; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ion Channel Gating; Male; Muscle Contraction; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Poisoning; Pyridinium Compounds; Sarin; Soman | 2011 |
Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.
Topics: Butyrylcholinesterase; Humans; Kinetics; Molecular Dynamics Simulation; Mutation; Organophosphate Poisoning; Organophosphorus Compounds; Protein Conformation; Quantum Theory; Sarin; Thermodynamics | 2012 |
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman | 2013 |
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication.
Topics: Acetylcholine; Adenosine; Animals; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Male; Microdialysis; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Parathion; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Sarin | 2002 |
Diagnosis and management of nerve agent exposure.
Topics: Antidotes; Atropine; Benzodiazepines; Bioterrorism; Chemical Warfare Agents; Child; Environmental Exposure; Humans; Organophosphate Poisoning; Resuscitation; Sarin; Triage | 2003 |
The effect of the sarinase levels of liver on the survival of rabbits injected with sarin.
Topics: Animals; Blood; Cholinesterase Inhibitors; Cholinesterases; Enzymes; Liver; Organophosphate Poisoning; Phosphates; Rabbits; Sarin | 1956 |
Studies on a group of oximes as therapeutic compounds in sarin poisoning.
Topics: Cholinesterase Inhibitors; Hydroxylamines; Organophosphate Poisoning; Oximes; Phosphates; Sarin | 1957 |
Oximes and atropine in sarin poisoning.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diacetyl; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Hydroxylamines; Mice; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Rats; Sarin | 1957 |
Pyridine-2-aldoxime methiodide in the treatment of sarin and tabun poisoning, with notes on its pharmacology.
Topics: Cholinesterase Inhibitors; Organophosphate Poisoning; Organophosphates; Phosphates; Picolines; Pralidoxime Compounds; Sarin | 1957 |
Influence of physical activity on the toxicity of aerosols and vapors; inhalation toxicity of paraoxon and sarin in rats.
Topics: Administration, Inhalation; Aerosols; Animals; Autonomic Agents; Cholinesterase Inhibitors; Exercise; Motor Activity; Organophosphate Poisoning; Paraoxon; Parathion; Phosphates; Rats; Sarin | 1958 |
Comparative lung-airway resistance and cardiovascular effects in dogs and monkeys following parathion and sarin intoxication.
Topics: Airway Resistance; Animals; Cardiovascular System; Cholinesterase Inhibitors; Dogs; Haplorhini; Organophosphate Poisoning; Parathion; Phosphates; Sarin | 1958 |
2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.
Topics: Animals; Atropine; Diphosphates; Humans; Insecticides; Male; Mesylates; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridinium Compounds; Sarin | 1959 |
Influence of solvents and surface active agents on the barrier function of the skin towards sarin. I. Development of method.
Topics: Organophosphate Poisoning; Phosphorus; Poisons; Sarin; Skin; Solvents; Surface-Active Agents | 1963 |
[ACTION OF GAMMA-RAYS ON CHOLINESTERASE AND OF THE EFFECTS OF SARIN].
Topics: Cholinesterases; Gamma Rays; Mice; Organophosphate Poisoning; Pharmacology; Phosphorus; Poisons; Radiation Effects; Research; Sarin | 1963 |
A COMPARATIVE STUDY OF SOME PYRIDINIUM OXIMES AS REACTIVATORS OF PHOSPHORYLATED ACETYLCHOLINESTERASE AND AS ANTIDOTES IN SARIN POISONING.
Topics: Acetylcholinesterase; Antidotes; Enzyme Inhibitors; Mice; Organophosphate Poisoning; Oximes; Pharmacology; Phosphorus; Phosphorylation; Poisons; Pyridines; Rabbits; Research; Sarin; Toxicology | 1963 |
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
Topics: Atropine; Cholinesterase Inhibitors; Enzyme Inhibitors; Mice; Neostigmine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pharmacology; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Rats; Research; Sarin; Soman; Toxicology | 1963 |
INCREASED CONCENTRATIONS OF BLOOD LIPIDS IN GUINEA PIGS POISONED BY SARIN.
Topics: Atropine; Blood Chemical Analysis; Guinea Pigs; Hyperlipidemias; Lipids; Muscle Spasticity; Organophosphate Poisoning; Oximes; Paralysis; Phosphorus; Poisons; Research; Sarin; Toxicology | 1963 |
CHOLINOLYTICS IN THE TREATMENT OF ANTICHOLINESTERASE POISONING. III. THE EFFECTS OF QUATERNIZATION AND ALTERATION OF ANIONIC FUNCTION OF THE POTENCY OF CHOLINOLYTICS IN THE TREATMENT OF SARIN POISONING.
Topics: Absorption; Ammonium Compounds; Atropine; Autonomic Agents; Blood Chemical Analysis; Cholinergic Antagonists; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Oximes; Parasympatholytics; Phosphorus; Poisons; Quaternary Ammonium Compounds; Research; Sarin; Therapeutics; Toxicology | 1963 |
The birth of nerve agent warfare: lessons from Syed Abbas Foroutan.
Topics: Antidotes; Chemical Warfare; Chemical Warfare Agents; Clinical Protocols; Diagnosis, Differential; Emergency Medical Services; History, 20th Century; Humans; Iran; Iraq; Male; Military Medicine; Military Personnel; Organophosphate Poisoning; Organophosphates; Poisoning; Sarin; Triage; United Nations; Warfare | 2004 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors | 2006 |
Overcoming inhibitions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors | 2006 |
Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinergic Antagonists; Cyclopentanes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Infusions, Parenteral; Lethal Dose 50; Male; Metabolic Clearance Rate; Organophosphate Poisoning; Organophosphates; Papio anubis; Poisoning; Pyridostigmine Bromide; Sarin; Species Specificity; Treatment Outcome | 2007 |
Oxime use after deliberate release.
Topics: Chemical Warfare; Cholinesterase Reactivators; Humans; Meta-Analysis as Topic; Organophosphate Poisoning; Oximes; Sarin | 2006 |
Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants.
Topics: Animals; Cholinesterase Inhibitors; Female; Interferon-gamma; Interleukin-2; Interleukin-4; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Poisoning; Rats; Rats, Wistar; Sarin; Th1 Cells; Th2 Cells | 2007 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
Sarin poisoning in guinea pigs compared to reactivation of acetylcholinesterase in vitro as a basis for therapy.
Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Female; Guinea Pigs; In Vitro Techniques; Lethal Dose 50; Male; Obidoxime Chloride; Organophosphate Poisoning; Sarin; Species Specificity | 1984 |
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman | 1983 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Phosphotriesterase--a promising candidate for use in detoxification of organophosphates.
Topics: Adult; Animals; Aryldialkylphosphatase; Brain; Cholinesterase Reactivators; Cholinesterases; Esterases; Female; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred Strains; Middle Aged; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Sarin; Soman | 1994 |
Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Drug Synergism; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Sarin | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 1996 |
QTc prolongation and cardiac lesions following acute organophosphate poisoning in rats.
Topics: Acute Disease; Animals; Body Weight; Chemical Warfare Agents; Cholinesterase Inhibitors; Electrocardiography; Heart Diseases; Long QT Syndrome; Myocardium; Organophosphate Poisoning; Rats; Rats, Sprague-Dawley; Sarin; Soman | 2001 |
Dual mechanism of the antidotal action of atropine-like drugs in poisoning by organophosphorus anticholinesterases.
Topics: Animals; Anticonvulsants; Antidotes; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Mice; Mydriatics; Nicotine; Organophosphate Poisoning; Parasympatholytics; Pentylenetetrazole; Rats; Sarin; Stereoisomerism; Time Factors | 1977 |
The prophylactic use of l-methyl, 2-hydroxyiminomethylpyridinium methanesulfonate (P2S) in the treatment of organophosphate poisoning.
Topics: Animals; Atropine; Drug Therapy, Combination; Female; Guinea Pigs; Lethal Dose 50; Mesylates; Organophosphate Poisoning; Pralidoxime Compounds; Rabbits; Sarin; Soman; Time Factors | 1977 |
Long-term effects of an organophosphate upon the human electroencephalogram.
Topics: Adult; Electroencephalography; Female; Humans; Hyperventilation; Male; Middle Aged; Occupational Diseases; Organophosphate Poisoning; Sarin; Sleep; Time Factors | 1979 |
The influence of 2-/o-cresyl/-4 H-1 : 3 : 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cyclic P-Oxides; Drug Interactions; Liver; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sarin; Soman; Structure-Activity Relationship | 1979 |
Antidotes or organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes.
Topics: Acetylcholinesterase; Animals; Antidotes; Body Temperature; Cattle; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Enzyme Reactivators; Female; Goats; Guinea Pigs; Half-Life; In Vitro Techniques; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Rabbits; Rats; Rats, Inbred Strains; Sarin; Solubility; Structure-Activity Relationship | 1979 |
Sarin and adrenergic--cholinergic interaction in rat brain.
Topics: Animals; Catecholamines; Fluorescence; Formaldehyde; Frozen Sections; Locus Coeruleus; Male; Organophosphate Poisoning; Rats; Sarin; Substantia Nigra | 1977 |
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime | 1975 |
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman | 1992 |
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin | 1992 |
Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.
Topics: Animals; Behavior, Animal; Butyrylcholinesterase; Learning; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Poisoning; Sarin; Soman | 1991 |
A symptomatological assessment of organophosphate-induced lethality in mice: comparison of atropine and clonidine protection.
Topics: Animals; Atropine; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Sarin | 1991 |
Histochemical demonstration of calcium accumulation in muscle fibres after experimental organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Calcium; Diaphragm; Histocytochemistry; Lethal Dose 50; Male; Mice; Muscles; Organophosphate Poisoning; Sarin | 1990 |
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Female; Ganglionic Blockers; Grasshoppers; In Vitro Techniques; Muscle Contraction; Organophosphate Poisoning; Organothiophosphorus Compounds; Physostigmine; Rana pipiens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarin; Synapses | 1985 |
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin | 1987 |
Choline transport and metabolism in soman- or sarin-intoxicated brain.
Topics: Acetylcholine; Animals; Biological Transport; Blood-Brain Barrier; Brain; Choline; Cholinesterase Inhibitors; Dogs; In Vitro Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman | 1988 |
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |
Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning.
Topics: Acetylcholinesterase; Action Potentials; Animals; Atropine; Body Weight; Brain; Brain Chemistry; Cholinesterases; Female; gamma-Aminobutyric Acid; Muscle Contraction; Muscles; Neostigmine; Organophosphate Poisoning; Physostigmine; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Sarin | 1986 |
Accidental exposure to sarin: vision effects.
Topics: Accommodation, Ocular; Cholinesterases; Color Perception; Humans; Intraocular Pressure; Male; Middle Aged; Occupational Diseases; Organophosphate Poisoning; Pupil; Sarin; Vision Disorders; Visual Acuity; Visual Fields | 1985 |
Sarin intoxication elevates plasma pralidoxime.
Topics: Animals; Guinea Pigs; Organophosphate Poisoning; Pralidoxime Compounds; Regional Blood Flow; Sarin | 1985 |
Treatment of poisoning by soman.
Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Physostigmine; Pyridostigmine Bromide; Sarin; Soman; Time Factors | 1985 |
Atropine-insensitive vasodilatation and hypotension in the organophosphate-poisoned rabbit.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cholinesterase Inhibitors; Forelimb; Heart Rate; Hypotension; Isoflurophate; Organophosphate Poisoning; Rabbits; Respiration, Artificial; Sarin; Soman; Vascular Resistance; Vasodilator Agents | 1972 |
[Efficacy of pyridinium salts in tabun and sarin poisoning in vivo and in vitro].
Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Mice; Mice, Inbred Strains; Nitriles; Organophosphate Poisoning; Oximes; Poisoning; Pyridinium Compounds; Sarin; Time Factors | 1973 |
[Therapeutic action of some pyridine series dioximes in experimental O-isopropyl-methyl-fluorophosphonate poisoning].
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Drug Combinations; Male; Mice; Organophosphate Poisoning; Oximes; Pyridines; Sarin | 1973 |
The influence of obidoxime on acetylcholinesterase activity in different parts of the mouse brain following isopropylmethyl phosphonofluoridate intoxication.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Diencephalon; Dose-Response Relationship, Drug; Male; Medulla Oblongata; Mesencephalon; Mice; Organophosphate Poisoning; Pons; Pyridinium Compounds; Sarin | 1972 |