sarcophine and Seizures

sarcophine has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for sarcophine and Seizures

Article	Year
Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors. Neurotoxicology, 2020, Volume: 80 The inhibitory glycine receptor (GlyR) is a key mediator of synaptic signalling in spinal cord, brain stem, and higher centres of the central nervous system. We examined the glycinergic activity of sarcophine (SN), a marine terpenoid known for its various biological activities, and its trans-diol derivative (7S, 8R)-dihydroxy-deepoxysarcophine (DSN). SN was isolated from the Red Sea soft coral Sacrophyton glaucum, DSN was semisynthesized by hydrolysis of the epoxide ring. In cytotoxicity tests against HEK293 cells, SN and DSN had LD Topics: 4-Butyrolactone; Animals; Anthozoa; Binding Sites; Binding, Competitive; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Male; Mice; Protein Binding; Receptors, Glycine; Seizures; Strychnine	2020

Article

Year

Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors.

Neurotoxicology, 2020, Volume: 80

The inhibitory glycine receptor (GlyR) is a key mediator of synaptic signalling in spinal cord, brain stem, and higher centres of the central nervous system. We examined the glycinergic activity of sarcophine (SN), a marine terpenoid known for its various biological activities, and its trans-diol derivative (7S, 8R)-dihydroxy-deepoxysarcophine (DSN). SN was isolated from the Red Sea soft coral Sacrophyton glaucum, DSN was semisynthesized by hydrolysis of the epoxide ring. In cytotoxicity tests against HEK293 cells, SN and DSN had LD

Topics: 4-Butyrolactone; Animals; Anthozoa; Binding Sites; Binding, Competitive; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Male; Mice; Protein Binding; Receptors, Glycine; Seizures; Strychnine

2020