saquinavir has been researched along with Candidiasis* in 2 studies
2 other study(ies) available for saquinavir and Candidiasis
| Article | Year |
|---|---|
Exposure to therapeutic concentrations of ritonavir, but not saquinavir, reduces secreted aspartyl proteinase of Candida parapsilosis.
The effect of ritonavir and saquinavir, HIV proteinase inhibitors, on the secreted aspartyl proteinase (Sap) activity of Candida parapsilosis was studied. In a proteinase-inducing medium (yeast carbon base-bovine serum albumin), Sap activity in all clinical isolates of C. parapsilosis (n = 20) was observed at 37 degrees C but not at 22 degrees C. The presence of ritonavir at a concentration of 8 microg/ml produced an inhibition close to 50% albumin consumption and also delayed yeast growth; however, saquinavir did not have any effect on growth or on Sap activity. In Sabouraud broth, which does not induce Sap production, no effect was shown on yeast growth by either of the two HIV proteinase inhibitors studied. Topics: Aspartic Acid Endopeptidases; Candida; Candidiasis; Dose-Response Relationship, Drug; HIV Protease Inhibitors; Ritonavir; Saquinavir | 2005 |
The inhibition of Candida-albicans-secreted aspartic proteases by three different HIV protease inhibitors.
Topics: Aspartic Acid Endopeptidases; Candida albicans; Candidiasis; Dose-Response Relationship, Drug; HIV Protease Inhibitors; Humans; Indinavir; Isoenzymes; Pichia; Recombinant Fusion Proteins; Ritonavir; Saquinavir | 1999 |