Page last updated: 2024-08-21

sapropterin and Vascular Diseases

sapropterin has been researched along with Vascular Diseases in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (6.25)	18.2507
2000's	7 (43.75)	29.6817
2010's	8 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Celinska, J; Rangel Filho, A; Sethumadhavan, S; Vasquez-Vivar, J; Whitsett, J; Widlansky, M	1
Allen, D; Belfer, I; Channon, KM; Cunnington, C; Darbari, DS; Desai, K; Diaw, L; Dizon, M; Freeman, L; Goldman, D; Hartley, SW; Kato, GJ; Milton, J; Nolan, V; Steinberg, MH; Taylor, JG; Wang, Z; Youngblood, V	1
Cheriyan, J; Day, L; Hall, FC; Mäki-Petäjä, KM; Östör, AJ; Shenker, N; Wilkinson, IB	1
Kenney, WL; Stanhewicz, AE	1
d'Uscio, LV; Katusic, ZS; Nath, KA	1
Kumagai, Y	1
Komai, N; Tomita, N	1
Förstermann, U	1
Kietadisorn, R; Kietselaer, BL; Moens, AL; Schmidt, HH	1
Channon, KM; Crabtree, MJ	1
Channon, KM; Guzik, TJ	1
Alp, NJ; Channon, KM	1
Channon, KM	1
Duncan, ER; Kahn, M; Kearney, MT; Wheatcroft, SB	1
Cosentino, F; Lüscher, TF	1
Katusic, ZS	1

Reviews

11 review(s) available for sapropterin and Vascular Diseases

Article	Year
Role of folic acid in nitric oxide bioavailability and vascular endothelial function. Nutrition reviews, 2017, Volume: 75, Issue:1 Topics: Antioxidants; Biological Availability; Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Randomized Controlled Trials as Topic; Vascular Diseases	2017
Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends in pharmacological sciences, 2009, Volume: 30, Issue:1 Topics: Animals; Biopterins; Blood Vessels; Clinical Trials as Topic; Drug Evaluation, Preclinical; Endothelium; Humans; Models, Theoretical; Vascular Diseases	2009
[Fusion of field and laboratory studies on the investigation of arsenic]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2009, Volume: 129, Issue:10 Topics: Animals; Arsenic Poisoning; Arsenicals; Biopterins; Chronic Disease; Endothelium, Vascular; Environmental Exposure; Humans; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Rabbits; Vascular Diseases	2009
Nitric oxide and oxidative stress in vascular disease. Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:6 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase	2010
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric oxide : biology and chemistry, 2011, Aug-01, Volume: 25, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Biological Transport; Biopterins; Dihydropteridine Reductase; Endothelial Cells; GTP Cyclohydrolase; Humans; Methotrexate; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pterins; Tetrahydrofolate Dehydrogenase; Vascular Diseases	2011
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2002, Volume: 53, Issue:4 Pt 1 Topics: Alleles; Arteriosclerosis; Biopterins; Blood Vessels; Endothelium, Vascular; Genetic Predisposition to Disease; Humans; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoproteins; Polymorphism, Genetic; Superoxides; Vascular Diseases	2002
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3 Topics: Animals; Biological Availability; Biopterins; Coenzymes; Diabetes Mellitus; Enzyme Induction; GTP Cyclohydrolase; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Mutant Strains; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pterins; Rabbits; Rats; Rats, Inbred Strains; Superoxides; Vascular Diseases	2004
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends in cardiovascular medicine, 2004, Volume: 14, Issue:8 Topics: Animals; Biopterins; Endothelium, Vascular; Humans; Mice; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Vascular Diseases	2004
Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Experimental physiology, 2008, Volume: 93, Issue:1 Topics: Animals; Atherosclerosis; Biological Availability; Biopterins; Calcium; Endothelial Cells; Humans; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Reactive Oxygen Species; Vascular Diseases	2008
Tetrahydrobiopterin and endothelial nitric oxide synthase activity. Cardiovascular research, 1999, Aug-01, Volume: 43, Issue:2 Topics: Antioxidants; Arginine; Biopterins; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Vascular Diseases	1999
Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:3 Topics: Animals; Antioxidants; Biopterins; Catalysis; Endothelium, Vascular; Humans; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Vascular Diseases; Vasomotor System	2001

Trials

1 trial(s) available for sapropterin and Vascular Diseases

Article	Year
Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis. Journal of the American Heart Association, 2016, Feb-19, Volume: 5, Issue:2 Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Biopterins; Cardiovascular Agents; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; England; Female; Humans; Inflammation Mediators; Male; Middle Aged; Nitric Oxide Synthase Type III; Pilot Projects; Pulse Wave Analysis; Time Factors; Treatment Outcome; Vascular Diseases; Vascular Stiffness; Vasodilation; Young Adult	2016

Article

Year

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.

Journal of the American Heart Association, 2016, Feb-19, Volume: 5, Issue:2

Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Biopterins; Cardiovascular Agents; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; England; Female; Humans; Inflammation Mediators; Male; Middle Aged; Nitric Oxide Synthase Type III; Pilot Projects; Pulse Wave Analysis; Time Factors; Treatment Outcome; Vascular Diseases; Vascular Stiffness; Vasodilation; Young Adult

2016

Other Studies

4 other study(ies) available for sapropterin and Vascular Diseases

Article	Year
Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. Free radical biology & medicine, 2013, Volume: 63 Topics: Animals; Biopterins; Cattle; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Superoxides; Tetrahydrofolate Dehydrogenase; Vascular Diseases	2013
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. American journal of hematology, 2014, Volume: 89, Issue:2 Topics: Adult; Alleles; Anemia, Sickle Cell; Biopterins; Case-Control Studies; Endothelium; Female; Gene Expression Regulation; Gene Frequency; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; GTP Cyclohydrolase; Haplotypes; Humans; Male; Middle Aged; Odds Ratio; Pain; Pain Management; Phenotype; Plethysmography; Sex Factors; Transcriptome; Vascular Diseases; Young Adult	2014
A weapon of endothelial cells for fighting vascular disease. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:2 Topics: Animals; Ascorbic Acid; Biopterins; Endothelial Cells; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Reactive Oxygen Species; Vascular Diseases	2010
Role of tetrahydrobiopterin (BH4) in hyperhomocysteinemia-induced endothelial dysfuction: new indication for this orphan-drug? American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:6 Topics: Biopterins; Coronary Circulation; Coronary Disease; Coronary Vessels; Endothelium, Vascular; Humans; Hyperhomocysteinemia; Nitric Oxide; Orphan Drug Production; Oxidation-Reduction; Ultrasonography; Vascular Diseases	2011