Compounds > sapropterin
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sapropterin and Reperfusion Injury

sapropterin has been researched along with Reperfusion Injury in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (7.41)18.2507
2000's10 (37.04)29.6817
2010's14 (51.85)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Bendall, JK; Channon, KM; Chu, SM; Chuaiphichai, S; Crabtree, MJ; Douglas, G; Heather, LC; Miossec, M; Nicol, T; Wright, B1
De Backer, D; Orbegozo, D; Rahmania, L; Su, F; Taccone, FS; Vincent, JL1
Kinoshita, H; Otake, K; Yamasaki, T1
Bienengraeber, M; Ge, ZD; Kersten, JR; Leucker, TM; Liu, Y; Procknow, J; Shi, Y; Warltier, DC1
Brandacher, G; Cardini, B; Channon, KM; Chuaiphichai, S; Hermann, M; Maglione, M; Oberhuber, R; Obrist, P; Pratschke, J; Watschinger, K; Werner, ER1
Ebner, S; Fabritius, C; Flörchinger, B; Hermann, M; Kotsch, K; Maglione, M; Nguyen, AV; Oberhuber, R; Obrist, P; Pratschke, J; Resch, T; Ritschl, P; Werner, ER1
Ambrosio, G; Boslett, J; De Pascali, F; Druhan, LJ; El-Mahdy, M; Hemann, C; Reyes, LA; Varadharaj, S; Zweier, JL1
Bernhard, D; Brandacher, G; Cardini, B; Golderer, G; Maglione, M; Messner, B; Oberhuber, R; Pratschke, J; Riede, G; Steger, C; Watschinger, K; Werner, ER1
Böhm, F; Channon, KM; Malmström, RE; Pernow, J; Settergren, M1
Tang, LL; Zheng, JS1
Channon, KM; Cunnington, C1
Brandacher, G; Cardini, B; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Oberhuber, R; Obrist, P; Pratschke, J; Schneeberger, S; Watschinger, K; Werner, ER; Werner-Felmayer, G1
Ince, C; Kandil, A; Legrand, M; Payen, D1
Fujita, M; Iwasaka, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K1
Cui, J; Cun, Y; Dai, Y; Shi, A1
Brandacher, G; Cardini, B; Gostner, J; Hermann, M; Jenny, M; Maglione, M; Margreiter, R; Oberhuber, R; Obrist, P; Pratschke, J; Watschinger, K; Werner, ER1
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L1
Arii, S; Hara, Y; Ishidate, K; Teramoto, K1
Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L1
Brandacher, G; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Obrist, P; Schneeberger, S; Werner, ER; Werner-Felmayer, G1
Fang, XH; Khiabani, KT; Stephenson, LL; Wang, WZ; Zamboni, WA1
Casas, JP; Harris, J; Heales, S; Hingorani, AD; MacAllister, RJ; Mayahi, L; Owen, D1
Ashwal, S; Cole, DJ; Pearce, WJ; Tian, HR; Tone, B1
Hillinger, S; Schaffner, A; Schmid, RA; Schoedon, G; Speich, R; Stammberger, U; Walter, R; Weder, W; Zollinger, A1
Hattori, Y; Hayakawa, H; Hirata, Y; Kakoki, M; Kikuchi, K; Nagano, T; Nagata, D; Nakanishi, N; Nishimatsu, H; Omata, M; Suzuki, E; Tojo, A1
Ishii, M; Kiuchi, Y; Nawata, S; Shimizu, S; Yamamoto, T1
Carboni, GL; Hillinger, S; Sandera, P; Schmid, RA; Schoedon, G; Stammberger, U; Zalunardo, M1

Reviews

1 review(s) available for sapropterin and Reperfusion Injury

ArticleYear
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
    Heart (British Cardiac Society), 2010, Volume: 96, Issue:23

    Topics: Animals; Autonomic Nervous System; Biopterins; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Reperfusion Injury

2010

Trials

2 trial(s) available for sapropterin and Reperfusion Injury

ArticleYear
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
    Atherosclerosis, 2009, Volume: 204, Issue:1

    Topics: Aged; Arginine; Biopterins; Blood Flow Velocity; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Reperfusion Injury; Treatment Outcome; Vasodilation; Vasodilator Agents

2009
(6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:6

    Topics: Acetylcholine; Adult; Antioxidants; Biopterins; Coenzymes; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Regional Blood Flow; Reperfusion Injury; Stereoisomerism; Time Factors; Vasodilation; Vasodilator Agents

2007

Other Studies

24 other study(ies) available for sapropterin and Reperfusion Injury

ArticleYear
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.
    Experimental physiology, 2023, Volume: 108, Issue:6

    Topics: Animals; Fatty Acids; Infarction; Mice; Myocytes, Cardiac; Nitric Oxide Synthase; Reperfusion Injury

2023
Administration of Tetrahydrobiopterin (BH4) Protects the Renal Microcirculation From Ischemia and Reperfusion Injury.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:4

    Topics: Animals; Biopterins; Female; Ischemia; Kidney; Microcirculation; Protective Agents; Random Allocation; Renal Circulation; Reperfusion Injury; Sheep

2017
The Unknown Mechanism of Exogenous Tetrahydrobiopterin in the Renal Protection of Sheep Ischemia and Reperfusion.
    Anesthesia and analgesia, 2018, Volume: 126, Issue:3

    Topics: Animals; Biopterins; Ischemia; Kidney; Microcirculation; Reperfusion Injury; Sheep

2018
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Animals; Biopterins; Cell Communication; Disease Susceptibility; Endothelial Cells; Glucose; Hyperglycemia; Male; Mice; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Multimerization; Protein Structure, Quaternary; Pterins; Rats; Reperfusion Injury

2013
Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Animals; Biopterins; Coenzymes; Cold Ischemia; Gene Expression; Graft Survival; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pancreas; Pancreas Transplantation; Reperfusion Injury

2014
Treatment with tetrahydrobiopterin overcomes brain death-associated injury in a murine model of pancreas transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015, Volume: 15, Issue:11

    Topics: Analysis of Variance; Animals; Biopterins; Brain Death; Disease Models, Animal; Graft Rejection; Graft Survival; Inflammation Mediators; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Pancreatitis; Postoperative Complications; Random Allocation; Reperfusion Injury

2015
Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Sep-15, Volume: 112, Issue:37

    Topics: ADP-ribosyl Cyclase 1; Animals; Biopterins; Coronary Artery Disease; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Heart; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADP; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Small Interfering

2015
Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model.
    Scientific reports, 2016, 11-24, Volume: 6

    Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Biopterins; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dimerization; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Smooth; Neointima; Nitric Oxide Synthase Type III; Oxygen; P-Selectin; Reperfusion Injury

2016
Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats.
    Neurological research, 2011, Volume: 33, Issue:10

    Topics: Animals; Biopterins; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2011
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2010, Volume: 10, Issue:10

    Topics: Animals; Biopterins; Cold Ischemia; Male; Mice; Mice, Inbred C57BL; Microcirculation; Models, Animal; Pancreas; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Tissue Donors; Transplantation, Isogeneic; Tyrosine

2010
Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats.
    Journal of cardiovascular pharmacology, 2011, Volume: 58, Issue:2

    Topics: Acute Kidney Injury; Animals; Aorta, Abdominal; Biopterins; Infusions, Intravenous; Kidney; Kidney Function Tests; Male; Microcirculation; Microvessels; Oxygen Consumption; Pterins; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury

2011
Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart.
    Free radical research, 2011, Volume: 45, Issue:10

    Topics: Acetylcysteine; Animals; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2011
Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice.
    The Journal of surgical research, 2012, Volume: 176, Issue:2

    Topics: Alanine Transaminase; Animals; Biopterins; Delayed Graft Function; Dinoprost; Liver; Liver Diseases; Liver Transplantation; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide Synthase Type III; Reperfusion Injury; Superoxides; Vitamin B 12

2012
Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin.
    Transplant international : official journal of the European Society for Organ Transplantation, 2012, Volume: 25, Issue:10

    Topics: Animals; Antioxidants; Ascorbic Acid; Biopterins; Cold Ischemia; Immunohistochemistry; Ischemia; Liver; Male; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy, Confocal; Nitric Oxide; Organ Preservation; Pancreas; Pancreas Transplantation; Reperfusion Injury; Tetrahydrofolates; Time Factors

2012
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6

    Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors

2003
Cytoprotective function of tetrahydrobiopterin in rat liver ischemia/reperfusion injury.
    Surgery, 2006, Volume: 139, Issue:3

    Topics: Animals; Biopterins; Liver; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Survival Analysis

2006
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
    Circulation research, 2006, Jul-07, Volume: 99, Issue:1

    Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine

2006
Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:7

    Topics: Animals; Biopterins; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Transplantation, Homologous; Tyrosine

2006
Effects of supplementation of BH4 after prolonged ischemia in skeletal muscle.
    Microsurgery, 2007, Volume: 27, Issue:3

    Topics: Animals; Biopterins; Cell Survival; Endothelium, Vascular; Injections, Intravenous; Male; Microcirculation; Muscle, Skeletal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vasodilation

2007
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.
    Stroke, 1998, Volume: 29, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Antioxidants; Arterial Occlusive Diseases; Biopterins; Brain Ischemia; Cerebral Arteries; Cricetinae; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Isoflurane; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Reperfusion; Reperfusion Injury; Time Factors

1998
The nitric oxide synthase cofactor tetrahydrobiopterin reduces allograft ischemia-reperfusion injury after lung transplantation.
    The Journal of thoracic and cardiovascular surgery, 1999, Volume: 118, Issue:4

    Topics: Animals; Antioxidants; Biopterins; Cryopreservation; Cyclic GMP; Dextrans; Disease Models, Animal; Edema; Endothelium, Vascular; Extravascular Lung Water; Free Radical Scavengers; Hemodynamics; Infusions, Intravenous; Injections, Intravenous; Lipid Peroxidation; Lung Diseases; Lung Transplantation; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase; Plasma Substitutes; Potassium; Pulmonary Veins; Reactive Oxygen Species; Reperfusion Injury; Swine

1999
Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:2

    Topics: Acute Kidney Injury; Animals; Biopterins; Endothelium, Vascular; Ischemia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury

2000
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: protective effect of tetrahydrobiopterin.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:1

    Topics: Animals; Antioxidants; Biopterins; Male; Nitric Oxide; Pteridines; Pterins; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Stomach

2000
Survival and graft function in a large animal lung transplant model after 30 h preservation and substitution of the nitric oxide pathway.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2001, Volume: 20, Issue:3

    Topics: Animals; Biopterins; Cell Movement; Coenzymes; Cyclic GMP; Extravascular Lung Water; Graft Survival; Hemodynamics; Infusions, Intravenous; Lipid Peroxidation; Lung; Lung Transplantation; Neutrophils; Nitric Oxide Synthase; Organ Preservation; Organ Preservation Solutions; Peroxidase; Pulmonary Gas Exchange; Reperfusion Injury; Swine; Thiobarbituric Acid Reactive Substances; Time Factors

2001