Compounds > sapropterin
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sapropterin and Pulmonary Hypertension

sapropterin has been researched along with Pulmonary Hypertension in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's5 (26.32)29.6817
2010's12 (63.16)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Aschner, JL; Cunningham, G; Dikalova, A; Fike, CD; Kaplowitz, MR; Summar, M1
Almudéver, P; Cogolludo, A; Cortijo, J; De Diego, A; Milara, J; Perez-Vizcaino, F; Serrano-Mollar, A; Xaubet, A1
Bergmeister, H; Bonderman, D; Jakowitsch, J; Lang, IM; Mascherbauer, J; Panzenböck, A; Schreiber, C; Strobl, M; Wexberg, P; Winter, MP1
Bertram, K; Chalupsky, K; Görlach, A; Kanchev, I; Kračun, D1
Li, XJ; Tie, L; Wang, ZF1
Aschner, JL; Dikalova, A; Fike, CD; Kaplowitz, MR; Summar, M1
Channon, KM; Cunnington, C1
Gibson, CL; Kunuthur, SP; Milliken, PH; Suckling, CJ; Wadsworth, RM1
Cabrita, I; Christman, BW; Du, RH; Gibbs, JS; Gonzalez, R; Hemnes, AR; Howard, L; Meehan, S; Mendes, LA; Oyler, T; Robbins, IM; Wilkins, MR; Zhao, L1
Gielis, JF; Lin, JY; Moens, AL; Schmidt, HH; Van Schil, PE; Wingler, K1
Czech, L; Farrow, KN; Gugino, SF; Lakshminrusimha, S; Russell, JA; Soares, F; Steinhorn, RH; Wedgwood, S1
Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J1
Ďurišová, J; Herget, J; Koubský, K; Miková, D1
D'iakonov, KB; Davydova, MP; Liubitskiĭ, OB; Medvedeva, HA; Postnikov, AB1
Haworth, S; Heales, S; Jacques, TS; Lam, AA; Miller, A; Nandi, M; Stidwill, R; Vallance, P1
Alp, NJ; Bendall, JK; Channon, KM; Khoo, JP; Nicoli, T; Rockett, K; Wilkins, MR; Zhao, L1
Konduri, GG; Pritchard, KA; Shi, Y1
Brandt, A; Braun-Dullaeus, RC; Heerwagen, C; Kasper, M; Schmeisser, A; Schober, K; Schwencke, C; Steinbronn, N; Strasser, RH; Tausche, AK; Wunderlich, C1
McMurtry, IF; Rodman, DM; Sato, K1

Reviews

3 review(s) available for sapropterin and Pulmonary Hypertension

ArticleYear
[Tetrahydrobiopterin Synthesis and Biological Function].
    Sheng li ke xue jin zhan [Progress in physiology], 2015, Volume: 46, Issue:4

    Topics: Antioxidants; Biopterins; Diabetes Mellitus; Heart; Humans; Hypertension, Pulmonary; Nitric Oxide Synthase; Nitric Oxide Synthase Type III

2015
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
    Heart (British Cardiac Society), 2010, Volume: 96, Issue:23

    Topics: Animals; Autonomic Nervous System; Biopterins; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Reperfusion Injury

2010
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders.
    Free radical biology & medicine, 2011, Apr-01, Volume: 50, Issue:7

    Topics: Arginine; Atherosclerosis; Biopterins; Blood Pressure; Cardiac Surgical Procedures; Cell Adhesion; Endothelium, Vascular; Folic Acid; Humans; Hypertension, Pulmonary; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Reactive Oxygen Species; Vasodilation; Ventricular Remodeling

2011

Trials

1 trial(s) available for sapropterin and Pulmonary Hypertension

ArticleYear
Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.
    Experimental lung research, 2011, Volume: 37, Issue:1

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Biomarkers; Biopterins; Chemokine CCL2; Drug Therapy, Combination; Endothelin Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; London; Male; Middle Aged; Natriuretic Peptide, Brain; Nitric Oxide; Oxidative Stress; Peptide Fragments; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Recovery of Function; Sildenafil Citrate; Sulfones; Tennessee; Time Factors; Treatment Outcome; Walking

2011

Other Studies

15 other study(ies) available for sapropterin and Pulmonary Hypertension

ArticleYear
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 04-01, Volume: 318, Issue:4

    Topics: Animals; Animals, Newborn; Arginine; Biopterins; Citrulline; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; Swine; Vascular Resistance

2020
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.
    Thorax, 2013, Volume: 68, Issue:10

    Topics: Aged; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liquid; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; GTP Cyclohydrolase; Humans; Hypertension, Pulmonary; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Pulmonary Fibrosis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tyrosine

2013
Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.
    American journal of physiology. Lung cellular and molecular physiology, 2013, Oct-01, Volume: 305, Issue:7

    Topics: Animals; Arginine; Arterial Pressure; Biomarkers; Biopterins; Exhalation; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pneumonectomy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley

2013
Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.
    Antioxidants & redox signaling, 2015, Nov-10, Volume: 23, Issue:14

    Topics: Animals; Biopterins; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Endothelium, Vascular; Folic Acid; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Superoxides; Tetrahydrofolate Dehydrogenase; Vascular Remodeling; Ventricular Pressure

2015
Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
    American journal of physiology. Lung cellular and molecular physiology, 2016, Oct-01, Volume: 311, Issue:4

    Topics: Administration, Oral; Animals; Arterial Pressure; Biopterins; Cell Hypoxia; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Nitric Oxide Synthase Type III; Pulmonary Artery; Sus scrofa

2016
Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties.
    European journal of pharmacology, 2011, Jan-10, Volume: 650, Issue:1

    Topics: Animals; Biopterins; Calcimycin; Calcium; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Ionophores; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation

2011
Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Mar-15, Volume: 302, Issue:6

    Topics: Acetophenones; Animals; Animals, Newborn; Biopterins; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Hypertension, Pulmonary; Lung; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Pulmonary Artery; Reactive Oxygen Species; Sheep; Superoxides; Tyrosine; Vasoconstriction; Vasodilation

2012
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
    Free radical biology & medicine, 2012, Jul-15, Volume: 53, Issue:2

    Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination

2012
Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs.
    Respiratory physiology & neurobiology, 2013, Feb-01, Volume: 185, Issue:3

    Topics: Animals; Biopterins; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide; Rats; Rats, Wistar

2013
[Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2003, Volume: 89, Issue:12

    Topics: Animals; Biopterins; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Oxygen; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2003
Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse.
    Circulation, 2005, Apr-26, Volume: 111, Issue:16

    Topics: Animals; Arteries; Biopterins; Female; GTP Cyclohydrolase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mice; Mice, Mutant Strains; Muscle, Smooth, Vascular; Nitric Oxide; Pulmonary Circulation; Vascular Resistance

2005
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
    Circulation, 2005, Apr-26, Volume: 111, Issue:16

    Topics: Animals; Biopterins; Endothelium, Vascular; GTP Cyclohydrolase; Homeostasis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Mice; Mice, Transgenic; Nitric Oxide Synthase Type III; Pulmonary Circulation; Vasoconstriction

2005
Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice.
    Circulation, 2005, Apr-26, Volume: 111, Issue:16

    Topics: Animals; Biopterins; GTP Cyclohydrolase; Hypertension, Pulmonary; Hypoxia; Mice; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Circulation; Vasoconstriction

2005
The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium.
    Journal of molecular and cellular cardiology, 2008, Volume: 44, Issue:5

    Topics: Animals; Biopterins; Cardiovascular Diseases; Catheterization; Caveolin 1; Dietary Supplements; Endothelium, Vascular; Enzyme Activation; Heart Function Tests; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Diseases; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phenotype

2008
Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs.
    The American journal of physiology, 1999, Volume: 276, Issue:4

    Topics: Animals; Arginine; Biopterins; Egtazic Acid; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Luminescent Measurements; Lung; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Time Factors

1999