sapropterin has been researched along with Pregnancy in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (10.14) | 18.7374 |
| 1990's | 13 (18.84) | 18.2507 |
| 2000's | 21 (30.43) | 29.6817 |
| 2010's | 20 (28.99) | 24.3611 |
| 2020's | 8 (11.59) | 2.80 |
| Authors | Studies |
|---|---|
| Alp, NJ; Appari, M; Channon, KM; Chuaiphichai, S; Crabtree, MJ; Dickinson, Y; Douglas, G; Drydale, EN; Hale, AB; Leeson, P; Lewandowski, AJ; McNeill, E; Tan, CMJ; Vatish, M; Whiteman, C; Yu, GZ; Zhang, W | 1 |
| Au-Yeung, D; Channon, KM; Chuaiphichai, S; Dickinson, Y; Douglas, G; McNeill, E; Whiteman, CAR | 1 |
| Engineer, A; Feng, Q; Kim, MY; Lim, YJ; Lu, X; Norozi, K | 1 |
| Jeong, JW; Luo, K; Sharma, A; Shi, Z; Tan, S; Thirugnanam, K; Vasquez-Vivar, J | 1 |
| Kovács, B; Kukor, Z; Pánczél, Z; Supák, D; Valent, S | 1 |
| Chen, Z; Han, B; He, C; Hui, Q; Li, X; Shen, M; Wang, K; Wang, L; Ye, F; Zou, H | 1 |
| Endo, F; Ida, H; Ito, T; Kure, S; Matsubara, Y; Matuo, M; Nakamura, K; Ohura, T; Okano, Y; Okuyama, T; Owada, M; Shintaku, H; Takayanagi, M; Yoshino, M | 1 |
| Chikada, S; Kakurai, Y; Seki, S; Tamura, M; Wada, K | 1 |
| Antoniades, C; Böhm, F; Cerrato, R; Channon, KM; Crabtree, M; Kublickiene, K; Schiffrin, EL | 1 |
| Bruggemann, N; Giżewska, M; Karall, D; Klein, C; Knerr, I; Krzywińska-Zdeb, E; Kuseyri, O; Leuzzi, V; Monavari, AA; Opladen, T; Romanowska, H; Scholl-Bürgi, S; Weissbach, A; Yapıcı, Z | 1 |
| Arai-Ichinoi, N; Kure, S; Murayama, K; Sakamoto, O | 1 |
| Drysdale, TA; Engineer, A; Feng, Q; Kucey, AS; Lu, X; Norozi, K; Saiyin, T; Urquhart, BL | 1 |
| Adams, DJ; Bélanger-Quintana, A; Bhattacharya, K; Bushueva, TV; Cerone, R; Chien, YH; Chiesa, A; Coşkun, T; de Las Heras, J; Feillet, F; Katz, R; Lagler, F; Muntau, AC; Piazzon, F; Rohr, F; van Spronsen, FJ; Vargas, P; Wilcox, G | 1 |
| Leeming, R; Lucock, M | 1 |
| Derrick, M; Jiang, R; Luo, K; Tan, S; Vásquez-Vivar, J; Yu, L | 1 |
| Burton, BK; Cohen-Pfeffer, JL; Fong, CT; Grange, DK; Hillman, RE; Hunt, J; Mahoney, JJ; Vockley, J; Yano, S | 1 |
| Acosta, PB; Berry, GT; Bilder, DA; Blau, N; Bodamer, OA; Brosco, JP; Brown, CS; Burlina, AB; Burton, BK; Camp, KM; Chang, CS; Coates, PM; Cunningham, AC; Dobrowolski, SF; Ferguson, JH; Franklin, TD; Frazier, DM; Grange, DK; Greene, CL; Groft, SC; Harding, CO; Howell, RR; Huntington, KL; Hyatt-Knorr, HD; Jevaji, IP; Levy, HL; Lichter-Konecki, U; Lindegren, ML; Lloyd-Puryear, MA; MacDonald, A; Matalon, K; McPheeters, ML; Mitchell, JJ; Mofidi, S; Moseley, KD; Mueller, CM; Mulberg, AE; Nerurkar, LS; Ogata, BN; Pariser, AR; Parisi, MA; Prasad, S; Pridjian, G; Rasmussen, SA; Reddy, UM; Rohr, FJ; Singh, RH; Sirrs, SM; Stremer, SE; Tagle, DA; Thompson, SM; Urv, TK; Utz, JR; van Spronsen, F; Vockley, J; Waisbren, SE; Weglicki, LS; White, DA; Whitley, CB; Wilfond, BS; Yannicelli, S; Young, JM | 1 |
| Greene, CL; Longo, N | 1 |
| Debray, FG; Feillet, F; Fofou-Caillierez, MB; Lotz-Havla, AS; Muntau, AC; Puchwein-Schwepcke, A; Trefz, FF; van Spronsen, F | 1 |
| Aldámiz-Echevarría, L; Andrade, F; Couce, ML; Llarena, M | 1 |
| Ahring, K; Almeida, MF; Belanger-Quintana, A; Blau, N; Burlina, A; Cleary, M; Coskum, T; Dokoupil, K; Evans, S; Feillet, F; Giżewska, M; Gokmen Ozel, H; Kamieńska, E; Lammardo, AM; Lotz-Havla, AS; MacDonald, A; Maillot, F; Muntau, AC; Puchwein-Schwepcke, A; Robert, M; Rocha, JC; Santra, S; Skeath, R; Strączek, K; Trefz, FK; van Dam, E; van Rijn, M; van Spronsen, F; Vijay, S | 1 |
| Fuenzalida, B; Gutiérrez, J; Leiva, A; Pardo, F; Salomón, C; Sanhueza, C; Sobrevia, L; Toledo, F; Westermeier, F | 1 |
| Coskun, T; Dursun, A; Sivri, S; Tokatli, A; Yildiz, Y | 1 |
| Feillet, F | 1 |
| Koch, R | 1 |
| Cyryłowski, L; Giżewska, M; Hnatyszyn, G; Kubalska, J; Modrzejewska, M; Nestorowicz, B; Sagan, L; Walczak, M; Zekanowski, C | 1 |
| Davidge, ST; Sankaralingam, S; Xu, H | 1 |
| Derrick, M; Ji, X; Tan, S; Vásquez-Vivar, J; Whitsett, J; Yu, L | 1 |
| Harada, N; Ohira, T; Watanabe, Y; Yoshino, M | 1 |
| Boyzo-Montes de Oca, A; Gonzalez-Ramirez, M; Hernandez-Rodriguez, J; Manjarrez-Gutierrez, G | 1 |
| Kukor, Z; Valent, S | 1 |
| Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J | 1 |
| Iizuka, H; Kohashi, R; Mizuma, H; Mizutani, M; Nishimura, N; Nozaki, S; Tohyama, H; Watanabe, Y | 1 |
| Blau, N; Trefz, FK | 1 |
| Ishiko, O; Iwanaga, N; Nakai, Y; Nishio, J; Shintaku, H; Tachibana, D; Yamamasu, S | 1 |
| Akamine, EH; Carvalho, MH; de Britto, LR; Fortes, ZB; Franco, Mdo C; Kawamoto, EM; Muscara, MN; Nigro, D; Scavone, C; Teixeira, SA; Tostes, RC | 1 |
| Chien, YH; Hwu, WL; Liu, HM; Peng, SS; Tseng, WY | 1 |
| Artuch, R; Campistol, J; Gómez, L; Gutiérrez, A; Lambruschini, N; Mas, A; Mila, M; Pérez-Dueñas, B; Pineda, J; Vilaseca, MA | 1 |
| Guttler, F; Koch, R; Moseley, K | 1 |
| Cook, LG; Danchuk, S; Mitchell, BM; Puschett, JB | 1 |
| Bickel, H | 1 |
| Clow, CL; Scriver, CR | 2 |
| Hirayama, K; Kapatos, G; Zhu, M | 1 |
| Blau, N; Guardamagna, O; Heizmann, CW; Kierat, L; Leimbacher, W; Matasovic, A; Ponzone, A | 1 |
| Hatakeyama, K; Hoshiga, M; Kagamiyama, H; Shimada, M; Watanabe, M | 1 |
| Imamura, T; Isshiki, G; Nakajima, T; Oura, T; Sawada, Y; Shintaku, H | 2 |
| Hertelendy, F; Kukor, Z; Mészáros, G; Tóth, M | 1 |
| Abel, RM | 1 |
| Blau, N; de Klerk, JB; Duran, M; Heizmann, CW; Kierat, L; Smeitink, JA; Thöny, B | 1 |
| Kukor, Z; Sahin-Tóth, M; Tóth, M | 2 |
| Chen, RG; Chiang, SH; Hsiao, KJ; Liu, TT; Liu, XQ; Lu, SF; Wu, KF; Wu, SJ; Yu, WM | 1 |
| Kang, UJ; Kowlessur, D; Lei, XG; Milstien, S; Nakamura, K; Wiatr, T; Wright, DA | 1 |
| Matsumura, R | 1 |
| Kukor, Z; Tóth, M; Valent, S | 2 |
| Harding, CO | 1 |
| Chiang, SH; Hsiao, KJ; Liu, TT; Wu, SJ | 1 |
| Fukumasu, H; Fukumasu, Y; Ishiko, O; Ogita, S; Shintaku, H; Tachibana, D; Yamamasu, S; Yamano, T | 1 |
| Tóth, M | 1 |
| Goto, S; Hashimoto, R; Kitagami, T; Miura, H; Mizutani, M; Ohta, T; Omura, I | 1 |
| Hasegawa, H; Hirayama, K; Kapatos, G | 1 |
| Endres, W | 1 |
| Curtius, HC; Niederwieser, A | 2 |
| Matsuo, N | 1 |
12 review(s) available for sapropterin and Pregnancy
| Article | Year |
|---|---|
International best practice for the evaluation of responsiveness to sapropterin dihydrochloride in patients with phenylketonuria.
Topics: Biopterins; Consensus; Diet; Female; Humans; Internationality; Phenylketonurias; Physicians; Practice Guidelines as Topic; Pregnancy | 2019 |
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
Topics: Animals; Arginine; Biopterins; Borohydrides; Cholesterol; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy | 2015 |
[Phenylketonuria--toward a better carry-over care].
Topics: Adolescent; Adult; Amino Acids, Neutral; Biopterins; Continuity of Patient Care; Diet Therapy; Female; Humans; Infant, Newborn; Insurance, Life; Neonatal Screening; Phenylalanine; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy; Socioeconomic Factors; Young Adult | 2010 |
[Nitric oxide and preeclampsia].
Topics: Adult; Biopterins; Fatty Acids, Nonesterified; Female; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Placenta; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; Smoking; Superoxides | 2010 |
Phenylketonuria: epitome of human biochemical genetics (first of two parts).
Topics: Animals; Biopterins; Brain; Chromosome Mapping; Female; Homeostasis; Humans; Intellectual Disability; Liver; Mutation; Myelin Proteins; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pregnancy | 1980 |
Phenylketonuria and other phenylalanine hydroxylation mutants in man.
Topics: Alleles; Amino Acid Metabolism, Inborn Errors; Animals; Biopterins; Dihydropteridine Reductase; Female; Fetal Diseases; Gene Frequency; Genetic Carrier Screening; Heterozygote; Humans; Hydroxylation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pregnancy; Pregnancy Complications; Rats | 1980 |
[Hyperphenylalaninemia].
Topics: Biopterins; Female; Humans; Infant; Infant, Newborn; Intellectual Disability; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy; Psychomotor Disorders | 2000 |
[Role of tetrahydrobiopterin in the regulation of activity of human placental nitric oxide synthase in normal and pre-eclamptic pregnancies].
Topics: Arginine; Biopterins; Cytosol; Female; Humans; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy | 2002 |
[Differential diagnosis and therapy of various forms of hyperphenylalaninemia: facts and fiction].
Topics: Biopterins; Diagnosis, Differential; Female; Humans; Infant, Newborn; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pregnancy; Pregnancy Complications | 1992 |
[Detection, differential diagnosis, and prenatal diagnosis of tetrahydrobiopterin deficiency].
Topics: Alcohol Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Biopterins; Diagnosis, Differential; Female; Guanosine Triphosphate; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Phenylalanine; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis | 1987 |
Hyperphenylalaninemia syndromes: current status of diagnosis and management.
Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Female; Humans; Hydroxylation; Infant, Newborn; Phenylalanine; Phenylketonurias; Pregnancy; Prenatal Diagnosis; Syndrome | 1988 |
Tetrahydrobiopterin biosynthetic pathway and deficiency.
Topics: Alcohol Oxidoreductases; Biopterins; Female; Humans; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis | 1987 |
1 trial(s) available for sapropterin and Pregnancy
| Article | Year |
|---|---|
Tetrahydrobiopterin responsiveness in patients with phenylketonuria.
Topics: Adolescent; Adult; Biopterins; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Mutation; Phenotype; Phenylalanine; Phenylketonurias; Pregnancy | 2004 |
56 other study(ies) available for sapropterin and Pregnancy
| Article | Year |
|---|---|
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Topics: Animals; Biopterins; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Extracellular Vesicles; Female; Fetal Development; GTP Cyclohydrolase; Humans; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Placenta; Pregnancy; Uterus | 2021 |
Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
Topics: Animals; Biopterins; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Female; GTP Cyclohydrolase; Humans; Hypertension, Pregnancy-Induced; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy; Vasodilation; Vasodilator Agents | 2023 |
Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice.
Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Coronary Artery Disease; Coronary Vessels; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Pregnancy; Streptozocin | 2020 |
Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels.
Topics: Animals; Biopterins; Brain; Female; Fetal Hypoxia; Hypoxia-Ischemia, Brain; Placenta; Pregnancy; Rabbits | 2020 |
[Effect of pravastatin on tetrahydrobiopterin-sensitive and -resistant NO synthase activity of preeclamptic placentas].
Topics: Biopterins; Female; Humans; Nitric Oxide Synthase; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
The first study of successful pregnancies in Chinese patients with Phenylketonuria.
Topics: Adult; Biopterins; China; Diet; Disease Management; Female; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Neonatal Screening; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Young Adult | 2020 |
Guide for diagnosis and treatment of hyperphenylalaninemia.
Topics: Biopterins; Female; Humans; Japan; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy | 2021 |
Sapropterin for phenylketonuria: A Japanese post-marketing surveillance study.
Topics: Biopterins; Child, Preschool; Female; Humans; Japan; Male; Phenylalanine; Phenylketonurias; Pregnancy; Product Surveillance, Postmarketing | 2022 |
Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue.
Topics: Aged; Animals; Antioxidants; Aorta; Biopterins; Cell Line; Endothelin-1; Female; Human Umbilical Vein Endothelial Cells; Humans; Lung; Male; Mammary Arteries; Mice, Transgenic; Middle Aged; Nitric Oxide Synthase Type III; Pregnancy; Saphenous Vein; Subcutaneous Fat; Superoxides; Tissue Culture Techniques; Vasodilation | 2018 |
Pregnancy management and outcome in patients with four different tetrahydrobiopterin disorders.
Topics: Adolescent; Adult; Biopterins; Female; Humans; Infant, Newborn; Phenylketonurias; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Retrospective Studies; Young Adult | 2018 |
Successful control of maternal phenylketonuria by tetrahydrobiopterin.
Topics: Adult; Biopterins; Female; Humans; Phenylalanine; Phenylketonuria, Maternal; Pregnancy | 2018 |
Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice.
Topics: Animals; Biopterins; Diabetes, Gestational; Female; Heart Defects, Congenital; Mice; Pregnancy | 2018 |
Autism, seasonality and the environmental perturbation of epigenome related vitamin levels.
Topics: Biopterins; Child Development Disorders, Pervasive; Female; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Pregnancy; Prenatal Exposure Delayed Effects; Seasons; Ultraviolet Rays; Vitamins | 2013 |
Developmental susceptibility of neurons to transient tetrahydrobiopterin insufficiency and antenatal hypoxia-ischemia in fetal rabbits.
Topics: Age Factors; Animals; Animals, Newborn; Basal Ganglia; Biopterins; Cell Survival; Cerebral Cortex; Disease Susceptibility; Female; Fetus; Gestational Age; Hypoxia-Ischemia, Brain; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Organ Specificity; Phenylketonurias; Pregnancy; Primary Cell Culture; Rabbits; Thalamus | 2014 |
Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry.
Topics: Abortion, Spontaneous; Adult; Biopterins; Female; Humans; Obstetric Labor, Premature; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Pregnancy Outcome; Young Adult | 2014 |
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
Topics: Biopterins; Diet Therapy; Disease Management; Evidence-Based Medicine; Female; Humans; Infant, Newborn; National Institutes of Health (U.S.); Phenylketonurias; Practice Guidelines as Topic; Pregnancy; United States | 2014 |
National Institutes of Health (NIH) review of evidence in phenylalanine hydroxylase deficiency (phenylketonuria) and recommendations/guidelines for therapy from the American College of Medical Genetics (ACMG) and Genetics Metabolic Dietitians Internationa
Topics: Biopterins; Diet Therapy; Female; Humans; Phenylketonurias; Practice Guidelines as Topic; Pregnancy | 2014 |
Use of sapropterin dihydrochloride in maternal phenylketonuria. A European experience of eight cases.
Topics: Adult; Biopterins; Europe; Female; Fetal Blood; Genotype; Humans; Infant, Newborn; Nutritional Status; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pterins | 2014 |
A new case of maternal phenylketonuria treated with sapropterin dihydrochloride (6R-BH4).
Topics: Adult; Biopterins; Female; Humans; Phenylketonuria, Maternal; Pregnancy; Treatment Outcome | 2014 |
The challenges of managing coexistent disorders with phenylketonuria: 30 cases.
Topics: Adolescent; Adult; Autoimmune Diseases; Biopterins; Child; Child, Preschool; Chromosome Aberrations; Consanguinity; Diet; Disease Management; Europe; Female; Gastrointestinal Diseases; Humans; Infant; Male; Phenylalanine; Phenylketonurias; Pregnancy; Retrospective Studies; Turkey | 2015 |
Partial hydatidiform mole in a phenylketonuria patient treated with sapropterin dihydrochloride.
Topics: Adult; Biopterins; Female; Humans; Hydatidiform Mole; Phenylketonuria, Maternal; Pregnancy; Pregnancy Outcome | 2017 |
[BH4 in the management of phenylketonuria].
Topics: Biopterins; Female; Humans; Phenylketonurias; Pregnancy; Pregnancy Complications | 2008 |
Maternal phenylketonuria and tetrahydrobiopterin.
Topics: Biopterins; Child, Preschool; Congenital Abnormalities; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Microcephaly; Phenylketonuria, Maternal; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Risk Assessment; Treatment Outcome | 2008 |
Maternal tetrahydrobiopterin deficiency: the course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: Adolescent; Biopterins; Child; Child, Preschool; Delayed Diagnosis; Female; Humans; Infant, Newborn; Male; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Young Adult | 2009 |
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy | 2010 |
Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain.
Topics: Animals; Animals, Newborn; Biopterins; Brain; Brain Chemistry; Disease Models, Animal; Dystonia; Female; Fetal Development; Fetal Hypoxia; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Maternal-Fetal Exchange; Muscle Hypertonia; Nitric Oxide Synthase; Pregnancy; Pterins; Rabbits | 2009 |
Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats.
Topics: Animals; Biopterins; Brain Stem; Caloric Restriction; Dihydropteridine Reductase; Female; Fetal Growth Retardation; Male; Nutritional Status; Pregnancy; Rats; Rats, Wistar; Serotonin; Tryptophan Hydroxylase | 2010 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Biopterins; Female; Injections, Intraventricular; Locomotion; Pregnancy; Rats; Rats, Wistar; Serotonin | 2003 |
Potential role of tetrahydrobiopterin in the treatment of maternal phenylketonuria.
Topics: Biopterins; Child, Preschool; Diet, Protein-Restricted; Female; Follow-Up Studies; Genotype; Humans; Infant, Newborn; Male; Mutation; Neonatal Screening; Phenylalanine; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy | 2003 |
Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta.
Topics: Alcohol Oxidoreductases; Biopterins; Female; GTP Cyclohydrolase; Humans; Phosphorus-Oxygen Lyases; Placenta; Pregnancy; Time Factors | 2004 |
Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Topics: Animals; Antioxidants; Biopterins; Blotting, Western; Caloric Restriction; Endothelium, Vascular; Female; Fetal Nutrition Disorders; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tyrosine; Uterus; Vasodilation | 2004 |
Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
Topics: 5-Hydroxytryptophan; Axons; Biopterins; Brain Damage, Chronic; Cerebral Cortex; Child; Child, Preschool; Combined Modality Therapy; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence; Levodopa; Male; Neonatal Screening; Nerve Fibers, Myelinated; Phenylalanine; Phenylketonurias; Pregnancy | 2004 |
Tetrahydrobiopterin and maternal PKU.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Biopterins; Combined Modality Therapy; Diet, Protein-Restricted; Female; Humans; Infant, Newborn; Mutation; Neonatal Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy | 2005 |
Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.
Topics: Animals; Aorta; Biological Availability; Biopterins; Disease Models, Animal; Endothelium, Vascular; Female; Fetal Growth Retardation; Hypertension, Pregnancy-Induced; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Pregnancy; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2007 |
[Diet therapy and coenzyme therapy in hereditary metabolic diseases].
Topics: Biopterins; Child; Child, Preschool; Coenzymes; Female; Homocystinuria; Humans; Infant; Infant, Newborn; Male; Maple Syrup Urine Disease; Metabolism, Inborn Errors; Neurotransmitter Agents; Phenylketonurias; Pregnancy; Pregnancy Complications | 1983 |
American Academy of Pediatrics Committee on Genetics: New issues in newborn screening for phenylketonuria and congenital hypothyroidism.
Topics: Biopterins; Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant, Newborn; Mass Screening; Phenylalanine; Phenylketonurias; Pregnancy; Thyroid Hormones | 1982 |
Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biopterins; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; GTP Cyclohydrolase; Hypothalamus; Kinetics; Membrane Potentials; Mesencephalon; Neurons; Pregnancy; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transcription, Genetic; Veratridine | 1994 |
Antenatal diagnosis of tetrahydrobiopterin deficiency by quantification of pterins in amniotic fluid and enzyme activity in fetal and extrafetal tissue.
Topics: Alcohol Oxidoreductases; Amniotic Fluid; Biopterins; Female; Fetus; GTP Cyclohydrolase; Humans; Hydro-Lyases; Neopterin; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis; Pterins; Xanthopterin | 1994 |
Autoradiographic distribution of [14C]tetrahydrobiopterin and its developmental change in mice.
Topics: Aging; Animals; Autoradiography; Biopterins; Carbon Radioisotopes; Female; Fetus; GTP Cyclohydrolase; Liver; Male; Mice; Oxidation-Reduction; Phenylalanine Hydroxylase; Pregnancy; Time Factors; Tissue Distribution | 1993 |
Experimental research on a fetal treatment for tetrahydrobiopterin deficiency.
Topics: Adrenal Glands; Animals; Biopterins; Corpus Striatum; Dopamine; Epinephrine; Female; Fetal Blood; Guinea Pigs; Hypoxanthines; Infusions, Intravenous; Liver; Maternal-Fetal Exchange; Metabolism, Inborn Errors; Norepinephrine; Phenylalanine; Phenylketonurias; Pregnancy; Tyrosine | 1993 |
Experimental research on a new treatment for maternal phenylketonuria(PKU).
Topics: Animals; Biopterins; Brain; Disease Models, Animal; Female; Fetus; Guinea Pigs; Infusions, Intravenous; Liver; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Tyrosine | 1993 |
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta.
Topics: Arginine; Biopterins; Calcium; Citrulline; Enzyme Activation; Female; Humans; NADP; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pregnancy | 1996 |
The ontogeny of the peptide innervation of the human pylorus, with special reference to understanding the aetiology and pathogenesis of infantile hypertrophic pyloric stenosis.
Topics: Animals; Biopterins; Female; Gestational Age; Humans; Hypertrophy; Infant; Infant, Newborn; Male; Mice; Mice, Inbred Strains; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Pyloric Antrum; Pyloric Stenosis; Vagus Nerve; Vasoactive Intestinal Peptide | 1996 |
Tetrahydrobiopterin loading test in xanthine dehydrogenase and molybdenum cofactor deficiencies.
Topics: Administration, Oral; Adult; Antioxidants; Biopterins; Child, Preschool; Coenzymes; Female; Heterozygote; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Metalloproteins; Middle Aged; Molybdenum Cofactors; Pregnancy; Pteridines; Pterins; Xanthine Dehydrogenase; Xanthopterin | 1996 |
Tetrahydrobiopterin preferentially stimulates activity and promotes subunit aggregation of membrane-bound calcium-dependent nitric oxide synthase in human placenta.
Topics: Biopterins; Calcium; Cytosol; Dimerization; Enzyme Activation; Female; Humans; In Vitro Techniques; Intracellular Membranes; Microsomes; Nitric Oxide Synthase; Placenta; Pregnancy; Protein Conformation | 1997 |
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency.
Topics: Alcohol Oxidoreductases; Alleles; Amino Acid Substitution; Asian People; Biopterins; China; DNA Mutational Analysis; Female; Fetal Diseases; Gene Frequency; Humans; Multienzyme Complexes; Mutation; Pedigree; Phenylketonurias; Pregnancy; Prenatal Diagnosis; Taiwan | 1998 |
Differential response of basal and tetrahydrobiopterin-stimulated activities of placental type III nitric oxide synthase to sodium dodecyl sulphate: relation to dimeric structure.
Topics: Antioxidants; Biopterins; Dimerization; Dose-Response Relationship, Drug; Female; Freezing; Humans; Immunoblotting; Microsomes; Nitric Oxide Synthase; Placenta; Pregnancy; Sodium Dodecyl Sulfate | 1998 |
Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin.
Topics: Animals; Antioxidants; Biopterins; Buthionine Sulfoximine; Cell Survival; Dopamine; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parkinson Disease; Pregnancy; Pteridines; Pterins; Pyrazoles; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide | 2000 |
Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae from normal and pre-eclamptic pregnancies.
Topics: Adult; Biopterins; Cytosol; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Microsomes; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Placenta; Pre-Eclampsia; Pregnancy | 2000 |
'Mommy, why can't I have a hamburger like the other kids?'.
Topics: Adolescent; Adult; Biopterins; Diet, Protein-Restricted; Female; Genetic Therapy; Humans; Keratinocytes; Metabolic Clearance Rate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pregnancy; Skin Transplantation | 2000 |
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Topics: 5-Hydroxytryptophan; Biopterins; Diagnosis, Differential; Dihydropteridine Reductase; Female; Genetic Carrier Screening; Humans; Incidence; Levodopa; Mass Screening; Mutation; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis; Taiwan; Treatment Outcome | 2001 |
Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity.
Topics: Biopterins; Erythrocytes; Female; Humans; Neopterin; Phosphorus-Oxygen Lyases; Pregnancy; Reticulocytes | 2002 |
Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity.
Topics: Absorption; Antioxidants; Ascorbic Acid; Biopterins; Culture Media; Culture Techniques; Drug Synergism; Female; Humans; Hydrogen Peroxide; Microsomes; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidants; Oxidation-Reduction; Oxygen; Placenta; Pregnancy; Spectrophotometry, Ultraviolet | 2002 |
Plasma biopterin levels and depressive state in pregnancy and the early puerperal period.
Topics: Adult; Biomarkers; Biopterins; Depression, Postpartum; Depressive Disorder; Female; Humans; Pregnancy; Pregnancy Complications | 2002 |
Tetrahydrobiopterin turnover in cultured rat sympathetic neurons: developmental profile, pharmacologic sensitivity, and relationship to norepinephrine synthesis.
Topics: Animals; Biopterins; Cells, Cultured; Female; Ganglia, Sympathetic; Hypoxanthines; Immunohistochemistry; Microscopy, Phase-Contrast; Neurons; Norepinephrine; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine 3-Monooxygenase | 1992 |