Page last updated: 2024-08-21

sapropterin and Parkinson Disease

sapropterin has been researched along with Parkinson Disease in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (27.91)	18.7374
1990's	6 (13.95)	18.2507
2000's	21 (48.84)	29.6817
2010's	4 (9.30)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ansah, T; Channon, KM; Charlton, C; Gangula, PR; Hale, A; Kalpana, R; Sampath, C; Srinivasan, S	1
Channon, KM; Crabtree, MJ; Hale, AB; Lourenço-Venda, LL; Ryan, BJ; Wade-Martins, R	1
Nagatsu, I; Nagatsu, T	1
Furujo, M; Hara, S; Ichinose, H; Imamura, K; Inoue, H; Ishikawa, T; Kinoshita, M; Kondo, T; Koshiba, Y; Oeda, T; Takahashi, J; Takahashi, R	1
Ichinose, H; Nomura, T; Sumi-Ichinose, C	1
Boo, DH; Choi, HJ; Hwang, O; Kang, BY; Kim, EM; Kim, SS; Lim, JH; No, H	1
Kikuchi, S; Makita, Z; Niino, M; Shinpo, K; Takeuchi, M; Tashiro, K; Tsuji, S; Yabe, I; Yamagishi, S	1
Choi, HJ; Hwang, O; Kim, SW; Lee, SY; Moon, YW	1
Choi, HJ; Hwang, O; Kim, SW; Lee, SY	1
Chang, JW; Hwang, O; Jang, YJ; Kim, SW	1
Chen, S; Dehua, X; Lingfei, X; Smith, SW; Xianwen, C; Zhenguo, L; Zhongcheng, Z	1
Hillard, CJ; Kalivendi, SV; Kalyanaraman, B; Kotamraju, S; Shang, T	1
Cho, Y; Choi, HJ; Hwang, O; Lee, SY	2
Aebischer, P; Bauer, M; Sajadi, A; Thöny, B	1
Cho, Y; Choi, HJ; Hwang, O; Kim, SW; Lee, SY; No, H	1
Hee Choi, D; Hwang, O; Jin Choi, H; Lee, SY; Moon, Y	1
Cui, J; DeStefano, AL; Guttman, M; Karamohamed, S; Laramie, JM; Latourelle, JC; McKee, AC; Myers, RH; Tobin, JE; Wilk, JB	1
Nagatsu, T; Sawada, M	1
Asanuma, M; Diaz-Corrales, FJ; Miyazaki, I; Miyoshi, K; Murata, M; Ogawa, N	1
Hirata, Y; Iizuka, R; Kondo, T; Nagatsu, I; Nagatsu, T; Narabayashi, H; Oka, K; Rahman, MK; Trocewicz, J; Yamaguchi, T	1
Burton, K; Calne, DB	1
Nagatsu, T	2
Burns, RS; Calne, DB; Insel, T; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP	1
Curtius, HC; Levine, R; Müldner, H; Niederwieser, A	1
Ballenger, J; Calne, D; Levine, R; Lovenberg, W; Williams, A	1
Holdup, D; Liptrot, J; Phillipson, O	1
Hossain, MA; Weiner, N	1
Ichinose, H; Nagatsu, T	1
Ichinose, H; Inagaki, H; Nagatsu, T; Ohye, T; Suzuki, T	1
Antion, MD; Jaumotte, JD; Kapatos, G; Pearl, SM; Stanwood, GD; Zigmond, MJ	1
Kang, UJ; Kowlessur, D; Lei, XG; Milstien, S; Nakamura, K; Wiatr, T; Wright, DA	1
Fan, DS; Fujimoto, KI; Ichinose, H; Ikeguchi, K; Kume, A; Mizukami, H; Monahan, J; Muramatsu, SI; Nagatsu, I; Nagatsu, T; Nakano, I; Ogawa, M; Ozawa, K; Shen, Y; Suzuki, T; Urabe, M; Urano, F	1
Bindokas, VP; Elas, M; Halpern, HJ; Kang, UJ; Kowlessur, D; Marks, JD; Milstien, S; Nakamura, K	1
Gramsbergen, JB; Kornblit, B; Møller Dall, A; Sandberg, M; Zimmer, J	1
Koshimura, K; Masaki, T; Miwa, S; Watanabe, Y	1
Bjurling, P; Hartvig, P; Imamura, K; Koshimura, K; Långström, B; Mataga, N; Miwa, S; Onoe, H; Tedroff, J; Watanabe, Y	1
Dissing, IC; Gerdes, AM; Güttler, F; Lou, H; Lykkelund, C; Pakkenberg, H; Rasmussen, V	1
Arévalo, R; Castro, R; Palarea, MD; Pérez, J; Rodríguez, M	1
Armarego, WL; Behan, PO; Jacobson, W; Moore, AP	1
Horikoshi, T; Iizuka, R; Kondo, T; Nagatsu, I; Nagatsu, T; Narabayashi, H; Sawada, M	1

Reviews

8 review(s) available for sapropterin and Parkinson Disease

Article	Year
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects. Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:11 Topics: Animals; Antiparkinson Agents; Biopterins; Genetic Therapy; Humans; Parkinson Disease; Tyrosine 3-Monooxygenase	2016
Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. Journal of neural transmission. Supplementum, 2007, Issue:72 Topics: Biopterins; Corpus Striatum; Dopamine; Dopamine beta-Hydroxylase; Epinephrine; Forecasting; GTP Cyclohydrolase; Humans; Interleukin-6; Microdissection; Norepinephrine; Parkinson Disease; RNA, Messenger; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase	2007
Pharmacology of Parkinson's disease. Neurologic clinics, 1984, Volume: 2, Issue:3 Topics: Amantadine; Antidepressive Agents; Antiparkinson Agents; Biopterins; Dopamine; Histamine H1 Antagonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Norepinephrine; Parasympatholytics; Parkinson Disease	1984
[Parkinson's disease]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1984, Volume: 29, Issue:14 Topics: Aged; Biopterins; Brain; Catecholamines; Dopa Decarboxylase; Humans; Middle Aged; Parkinson Disease; Receptors, Dopamine; Tyrosine 3-Monooxygenase	1984
GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism. Neurochemical research, 1996, Volume: 21, Issue:2 Topics: Animals; Biopterins; Dopamine; Dystonia; GTP Cyclohydrolase; Haplorhini; Humans; Parkinson Disease; Parkinson Disease, Secondary; Tyrosine 3-Monooxygenase	1996
[A novel function of tetrahydrobiopterin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:5 Topics: Alzheimer Disease; Animals; Biopterins; Coenzymes; Humans; Mixed Function Oxygenases; Neurotransmitter Agents; Parkinson Disease; Tissue Distribution	1992
[Current perspectives in the treatment of Parkinson disease]. Medicina clinica, 1985, Nov-09, Volume: 85, Issue:15 Topics: Biopterins; Brain Chemistry; Dopamine; Dopamine Antagonists; Humans; Levodopa; Neurotransmitter Agents; Parkinson Disease; Synaptic Transmission; Tyrosine 3-Monooxygenase	1985
[Pathogenic substances in Parkinson disease and new therapeutics considering the etiologic mechanism]. Nihon rinsho. Japanese journal of clinical medicine, 1988, Volume: 46, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Dopamine Agents; Droxidopa; Humans; Levodopa; Nerve Tissue; Parkinson Disease; Pyridines; Serine	1988

Trials

2 trial(s) available for sapropterin and Parkinson Disease

Article	Year
Tetrahydrobiopterin and Parkinson's disease. Acta neurologica Scandinavica, 1989, Volume: 79, Issue:6 Topics: Adult; Antiparkinson Agents; Benserazide; Biopterins; Clinical Trials as Topic; Drug Combinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine	1989
Biopterin in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:1 Topics: Adult; Biopterins; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Random Allocation	1987

Other Studies

33 other study(ies) available for sapropterin and Parkinson Disease

Article	Year
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease. Digestive diseases and sciences, 2019, Volume: 64, Issue:12 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Biopterins; Blotting, Western; Colon; Constipation; Disease Models, Animal; Enzyme Inhibitors; Gastric Emptying; Gastrointestinal Motility; Gene Expression Regulation; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; MPTP Poisoning; NF-E2-Related Factor 2; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Parkinson Disease; Parkinsonian Disorders; Tyrosine 3-Monooxygenase	2019
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine, 2014, Volume: 67 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; alpha-Synuclein; Biopterins; Cell Line, Tumor; Dopaminergic Neurons; Gene Expression Regulation; GTP Cyclohydrolase; Guanosine Triphosphate; Humans; Mitochondria; Models, Biological; Oxidative Phosphorylation; Parkinson Disease; RNA, Small Interfering	2014
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders. Human molecular genetics, 2016, 12-01, Volume: 25, Issue:23 Topics: Biopterins; Cell Differentiation; Dopamine; Dopaminergic Neurons; Genotype; Humans; Induced Pluripotent Stem Cells; Karyotype; Metabolic Diseases; Parkinson Disease; Pterins; Tyrosine 3-Monooxygenase	2016
Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders. Chemical record (New York, N.Y.), 2008, Volume: 8, Issue:6 Topics: Animals; Biogenic Monoamines; Biopterins; Dystonic Disorders; GTP Cyclohydrolase; Mice; Mice, Knockout; Mixed Function Oxygenases; Nervous System Diseases; Neurons; Parkinson Disease	2008
Protective effect of bromocriptine against BH4-induced Cath.a cell death involving up-regulation of antioxidant enzymes. Neuroscience letters, 2009, Feb-27, Volume: 451, Issue:3 Topics: Animals; Antioxidants; Biopterins; Bromocriptine; Cell Death; Cell Line; Cytochromes c; Dopamine; Dopamine Agonists; Enzymes; L-Lactate Dehydrogenase; Mice; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Phosphatidylinositol 3-Kinases; Receptors, Dopamine; Signal Transduction; Up-Regulation	2009
Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons. Brain research, 2003, Feb-28, Volume: 964, Issue:2 Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Biopterins; Cell Culture Techniques; Cell Survival; Cysteine Endopeptidases; Dopamine; Dose-Response Relationship, Drug; Glutathione; Immunoblotting; Mesencephalon; Mitochondria; Multienzyme Complexes; Neurons; Oligopeptides; Parkinson Disease; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2003
Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death. Experimental neurology, 2003, Volume: 181, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Biopterins; Calcium; Cell Death; Cell Line; Cysteine Proteinase Inhibitors; DNA Fragmentation; Dopamine; Female; In Situ Nick-End Labeling; Mice; Neurons; Parkinson Disease; Rats; Rats, Sprague-Dawley	2003
Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. Journal of neurochemistry, 2003, Volume: 86, Issue:1 Topics: Animals; Antioxidants; Biopterins; Cell Death; Cell Line; Central Nervous System; Dopamine; Humans; Iron Chelating Agents; Lipid Peroxidation; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; NAD(P)H Dehydrogenase (Quinone); Neuroblastoma; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Proteins; Quinones; Toxicity Tests; Tyrosine 3-Monooxygenase	2003
Degeneration of the nigrostriatal pathway and induction of motor deficit by tetrahydrobiopterin: an in vivo model relevant to Parkinson's disease. Neurobiology of disease, 2003, Volume: 13, Issue:2 Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Immunohistochemistry; Movement Disorders; Nerve Degeneration; Neural Pathways; Neurotoxins; Parkinson Disease; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase	2003
Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes. Parkinsonism & related disorders, 2003, Volume: 9 Suppl 2 Topics: Animals; Behavior, Animal; Biopterins; Brain; Cell Line, Transformed; Cell Transplantation; Denervation; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Therapy; GTP Cyclohydrolase; Oxidopamine; Parkinson Disease; Rats; Skin; Sympatholytics; Tyrosine 3-Monooxygenase	2003
1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18 Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Biopterins; Cerebellum; Electron Transport Complex I; Humans; Interneurons; Iron; Mitochondrial Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinson Disease; Rats; Reactive Oxygen Species; Receptors, Transferrin; Signal Transduction; Superoxides	2004
JNK activation by tetrahydrobiopterin: implication for Parkinson's disease. Journal of neuroscience research, 2004, Mar-01, Volume: 75, Issue:5 Topics: Animals; Antioxidants; Apoptosis; Biopterins; Brain; Cells, Cultured; Dopamine; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Neurons; Neurotoxins; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation	2004
Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. Neurochemistry international, 2005, Volume: 46, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Benzoquinones; Biopterins; Cell Death; Cell Line; Cytosol; Dimethyl Fumarate; Dopamine; Drug Resistance; Enzyme Inhibitors; Fumarates; Ketanserin; Lipid Peroxidation; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Monoamine Oxidase Inhibitors; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins	2005
Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of neurochemistry, 2005, Volume: 93, Issue:6 Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; GTP Cyclohydrolase; Lentivirus; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Growth Factors; Neural Pathways; Parkinson Disease; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins	2005
Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochemistry international, 2006, Volume: 48, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Biopterins; Cell Line; Cytochromes c; Dopamine; Humans; Membrane Potentials; Mitochondria; Oxidative Stress; Parkinson Disease; Rotenone	2006
Particular vulnerability of rat mesencephalic dopaminergic neurons to tetrahydrobiopterin: Relevance to Parkinson's disease. Neurobiology of disease, 2007, Volume: 25, Issue:1 Topics: Animals; Apoptosis; Biopterins; Caspase 3; Cell Count; Cells, Cultured; Coloring Agents; Cytochromes c; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Immunohistochemistry; In Situ Nick-End Labeling; Membrane Potentials; Mesencephalon; Neurons; Oxidative Stress; Parkinson Disease; Rats	2007
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain research, 2007, Mar-30, Volume: 1139 Topics: Aged; Alcohol Oxidoreductases; Aldehyde Reductase; Biopterins; Cerebellum; Female; Gene Expression Regulation; Genetic Predisposition to Disease; GTP Cyclohydrolase; Humans; Male; Middle Aged; Parkinson Disease; Phosphorus-Oxygen Lyases; Polymorphism, Single Nucleotide; Reference Values	2007
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation. Neuroscience research, 2008, Volume: 60, Issue:1 Topics: alpha-Synuclein; Animals; Antioxidants; Biopterins; Cell-Free System; Cells, Cultured; Cytosol; Dopamine; Isoxazoles; Ketanserin; Lewy Bodies; Melanins; Mice; Neurons; Oxidative Stress; Parkinson Disease; Quinones; Ubiquitin-Protein Ligases; Zonisamide	2008
Aetiology of Parkinson's disease. Lancet (London, England), 1984, Jan-21, Volume: 1, Issue:8369 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Biopterins; Dihydropteridine Reductase; Dopamine; Free Radicals; Humans; NADH, NADPH Oxidoreductases; Parkinson Disease; Pyridines	1984
Catecholamine-related enzymes and the biopterin cofactor in Parkinson's disease and related extrapyramidal diseases. Advances in neurology, 1984, Volume: 40 Topics: Adult; Aged; Aromatic-L-Amino-Acid Decarboxylases; Basal Ganglia Diseases; Biopterins; Brain; Dopa Decarboxylase; Dopamine beta-Hydroxylase; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylethanolamine N-Methyltransferase; Pteridines; Shy-Drager Syndrome; Tyrosine 3-Monooxygenase	1984
Tyrosine hydroxylase cofactor (tetrahydrobiopterin) in parkinsonism. Advances in neurology, 1984, Volume: 40 Topics: Adult; Age Factors; Aged; Animals; Antiparkinson Agents; Biopterins; Brain Chemistry; Drug Evaluation, Preclinical; Haplorhini; Humans; Middle Aged; Parkinson Disease; Pteridines; Rats	1984
Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease. Advances in neurology, 1984, Volume: 40 Topics: Aged; Antidepressive Agents; Antiparkinson Agents; Biopterins; Brain; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines	1984
Aging and CSF hydroxylase cofactor. Neurology, 1980, Volume: 30, Issue:11 Topics: Adult; Aged; Aging; Biopterins; Humans; Middle Aged; Parkinson Disease; Pteridines	1980
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol inhibits tyrosine hydroxylase activity in rat striatal synaptosomes. Journal of neural transmission. General section, 1994, Volume: 96, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dopamine; Isoquinolines; Monoamine Oxidase; NAD; Nerve Tissue Proteins; Nomifensine; Parkinson Disease; Rats; Selegiline; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase	1994
Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biopterins; Brain Diseases; Carbidopa; Corpus Striatum; Cyclic AMP; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Homovanillic Acid; Levodopa; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred F344; Receptors, Dopamine D1; Receptors, Dopamine D2; Sensitivity and Specificity; Substantia Nigra; Time Factors	1993
[The relation between metabolism of biopterin and dystonia-parkinsonism]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1999, Volume: 19, Issue:2 Topics: Animals; Biopterins; Chromosomes, Human, Pair 14; Dopamine; Dystonia; GTP Cyclohydrolase; Heterozygote; Humans; Parkinson Disease; Substantia Nigra	1999
Effects of NADH on dopamine release in rat striatum. Synapse (New York, N.Y.), 2000, Volume: 36, Issue:2 Topics: Animals; Antioxidants; Biopterins; Cell Culture Techniques; Dopamine; Extracellular Space; Male; NAD; Neostriatum; Parkinson Disease; Potassium Chloride; Rats; Rats, Sprague-Dawley; Time Factors	2000
Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. Journal of neurochemistry, 2000, Volume: 74, Issue:6 Topics: Animals; Antioxidants; Biopterins; Buthionine Sulfoximine; Cell Survival; Dopamine; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parkinson Disease; Pregnancy; Pteridines; Pterins; Pyrazoles; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide	2000
Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Human gene therapy, 2000, Jul-20, Volume: 11, Issue:11 Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Cell Line; Corpus Striatum; Dependovirus; Dopamine; Gene Expression Profiling; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; GTP Cyclohydrolase; Humans; Injections; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Time Factors; Transformation, Genetic; Transgenes; Tyrosine 3-Monooxygenase	2000
Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. The Journal of biological chemistry, 2001, Sep-14, Volume: 276, Issue:37 Topics: Animals; Biopterins; Dopamine; Female; Fibroblasts; Free Radical Scavengers; Mesencephalon; Mitochondria; Nitric Oxide; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides	2001
Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. Brain research, 2002, May-10, Volume: 935, Issue:1-2 Topics: Animals; Animals, Newborn; Biopterins; Buthionine Sulfoximine; Coculture Techniques; Dopamine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutathione; Homovanillic Acid; Hypoxanthines; Neostriatum; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase	2002
Tetrahydrobiopterin and dopamine release. The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:2 Topics: Animals; Biopterins; Brain; Brain Mapping; Dopamine; Glutamates; Glutamic Acid; Haplorhini; Humans; Parkinson Disease; Rats; Receptors, Dopamine; Second Messenger Systems; Serotonin; Synaptic Transmission	1991
Biosynthesis of tetrahydrobiopterin in parkinsonian human brain. Advances in neurology, 1987, Volume: 45 Topics: Biopterins; Brain; GTP Cyclohydrolase; Guanosine Triphosphate; Humans; Parkinson Disease; Radioimmunoassay	1987