sapropterin has been researched along with Innate Inflammatory Response in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Capuron, L; Castanon, N; Cussotto, S; Fanet, H; Monchaux De Oliveira, C; Vancassel, S | 1 |
| Abdel-Rafei, MK; Moustafa, EM; Rashed, ER; Thabet, NM | 1 |
| Bailey, JD; Channon, KM; Chuaiphichai, S; Crabtree, MJ; Davis, S; Diotallevi, M; Fischer, R; Hale, A; Kessler, BM; McCullagh, J; McNeill, E; McShane, H; Nandi, M; Nicol, T; Shaw, A; Starr, A; Stylianou, E | 1 |
| Bjerrum, OJ; Dalbøge, LS; Dupont, E; Heegaard, AM; Jensen, TS; Larsen, M; Møller, AT; Møller, LB; Nasser, A | 1 |
| Bendall, JK; Channon, KM; Crabtree, MJ; Douglas, G; McNeill, E | 1 |
| Andrews, N; Babaniyi, O; Barrett, LB; Blagg, J; Channon, KM; Chuaiphichai, S; Costigan, M; Cronin, SJ; Duong, K; Ferreirós, N; Fujita, M; Gorska, K; Hovius, R; Johnsson, K; Latini, A; Latremoliere, A; Miracca, G; Naylor, A; Painter, M; Penninger, JM; Remor, AP; Riva, P; Romero, C; Tegeder, I; Woolf, CJ; Zhong, J | 1 |
| Cai, H; Youn, JY; Zhou, J | 1 |
| Feuerbach, D; Kalkman, HO | 1 |
| Bernhard, D; Brandacher, G; Cardini, B; Golderer, G; Maglione, M; Messner, B; Oberhuber, R; Pratschke, J; Riede, G; Steger, C; Watschinger, K; Werner, ER | 1 |
| Harrison, DG; Loperena, R | 1 |
| Fuchs, D; Ledochowski, M; Neurauter, G; Scholl-Bürgi, S; Schröcksnadel, K; Schubert, C; Sperner-Unterweger, B | 1 |
| Bryan, NS; Dugas, TR; Garg, H; Guidry, E; Stokes, KY; Tang, Y | 1 |
| Chen, W; Harrison, DG; Jo, H; Li, L; Rezvan, A | 1 |
| Chappell, MC; Chen, AF; Gallagher, PE; Lindsey, SH; Varagic, J; Yamaleyeva, LM; Zhang, LL | 1 |
| Channon, KM; McNeill, E | 1 |
| Nomura, T; Ohtsuki, M; Shiraishi, H; Sumi-Ichinose, C | 1 |
| Kotsonis, P; Matter, H | 1 |
| Armato, U; Bortolotti, F; Chiarini, A; Dal Pra, I; Gottardo, R; Whitfield, JF | 1 |
| Eissa, NT; Kolodziejski, PJ; Koo, JS | 1 |
| Ren, J; Wu, S | 1 |
| Torreilles, F; Touchon, J | 1 |
8 review(s) available for sapropterin and Innate Inflammatory Response
| Article | Year |
|---|---|
Tetrahydrobiopterin in cardiovascular health and disease.
Topics: Atherosclerosis; Biopterins; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Humans; Inflammation; Nitric Oxide Synthase Type III; Oxidation-Reduction | 2014 |
Antidepressant therapies inhibit inflammation and microglial M1-polarization.
Topics: Animals; Antidepressive Agents; Biomarkers; Biopterins; Depression; Electroconvulsive Therapy; Humans; Inflammation; Lipopolysaccharides; Macrophages; Microglia; Phenotype; Risk Factors; Signal Transduction; Stress, Psychological | 2016 |
Oxidative Stress and Hypertensive Diseases.
Topics: Antioxidants; Biopterins; Blood Vessels; Central Nervous System; Humans; Hypertension; Inflammation; Kidney; Mitochondria; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; Xanthine Oxidase | 2017 |
Chronic immune stimulation correlates with reduced phenylalanine turnover.
Topics: Animals; Biogenic Monoamines; Biopterins; Homocysteine; Humans; Immune System; Inflammation; Interferon-gamma; Oxidative Stress; Phenylalanine | 2008 |
The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Topics: Animals; Biopterins; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Leukocytes; Models, Cardiovascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2012 |
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain Ischemia; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Neurodegenerative Diseases; Nitric Oxide Synthase; Protein Conformation; Pteridines; Quantitative Structure-Activity Relationship; Sepsis; Structure-Activity Relationship | 2004 |
A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction?
Topics: Animals; Biopterins; Cytokines; Diabetes Mellitus; Endothelin-1; Heart Diseases; Humans; Inflammation; Insulin Resistance; Myocardium; Nitric Oxide; Sepsis; Shock, Septic; Systemic Inflammatory Response Syndrome; Toll-Like Receptors | 2006 |
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biopterins; Brain; Brain Chemistry; Calcium; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Humans; Inflammation; Isoenzymes; Models, Biological; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofibrillary Tangles; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins | 2002 |
13 other study(ies) available for sapropterin and Innate Inflammatory Response
| Article | Year |
|---|---|
Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice.
Topics: Animals; Biopterins; Cytokines; Inflammation; Lipopolysaccharides; Mice; Phenylalanine; Tyrosine | 2022 |
Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Biopterins; Brain; Brain Injuries; Cranial Irradiation; Depression; Fluoxetine; Gamma Rays; Inflammation; Male; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Rats; Signal Transduction; Sildenafil Citrate; Simvastatin | 2021 |
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Topics: Animals; Biopterins; Citric Acid Cycle; Electron Transport; Endotoxemia; Glycolysis; GTP Cyclohydrolase; Inflammation; Interferon-gamma; Interleukin-1beta; Isocitrate Dehydrogenase; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Knockout; Mitochondria; Mycobacterium Infections; Nitric Oxide; Nitric Oxide Synthase Type II; Peptide Fragments; Proteome; Succinates; Succinic Acid; Tandem Mass Spectrometry | 2019 |
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Topics: Animals; Behavior, Animal; Biopterins; Biosynthetic Pathways; Capsaicin; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disease Models, Animal; Dystonic Disorders; Formaldehyde; Freund's Adjuvant; GTP Cyclohydrolase; Hot Temperature; Inflammation; Inheritance Patterns; Mice; Mice, Inbred C57BL; Motor Activity; Nociception; Pain; Phenylketonurias; Physical Stimulation; Rats; Stress, Mechanical | 2013 |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopterins; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; GTP Cyclohydrolase; Inflammation; Macrophages; Mice; Mice, Transgenic; Neuralgia; Pain Measurement; Pain Threshold; Reaction Time; Sciatic Nerve; Sensory Receptor Cells; Sulfasalazine; Time Factors | 2015 |
Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.
Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Glucose; Bone Morphogenetic Protein 4; Carrier Proteins; Cattle; Cells, Cultured; Cholesterol; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Inflammation; Male; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type III; RNA, Small Interfering; Superoxides | 2015 |
Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Biopterins; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dimerization; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Smooth; Neointima; Nitric Oxide Synthase Type III; Oxygen; P-Selectin; Reperfusion Injury | 2016 |
Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Biopterins; Blood Pressure; C-Reactive Protein; Cholesterol, Dietary; Diet; Disease Models, Animal; Endothelium, Vascular; Hypercholesterolemia; Inflammation; Leukocyte Rolling; Liver; Male; Mice; Mice, Inbred C57BL; Microvessels; Myocardium; Nitric Oxide; Sodium Nitrite; Triglycerides; Vasodilation; Vasodilator Agents | 2009 |
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biopterins; Carotid Artery, Common; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Inflammation; Inflammation Mediators; Ligation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Regional Blood Flow; Superoxides; T-Lymphocytes; Vasodilation; Vasodilator Agents | 2011 |
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.
Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Oxidative Stress; Rats; Rats, Inbred Lew; Renin; RNA, Messenger; Sodium Chloride, Dietary | 2012 |
[Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells].
Topics: Biopterins; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Feedback, Physiological; GTP Cyclohydrolase; Humans; Inflammation; Muscle, Smooth, Vascular; Nitric Oxide; Protein Processing, Post-Translational; Signal Transduction; Umbilical Veins; Vasodilation | 2002 |
BH(4) (tetrahydrobiopterin)-dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)-2 in proinflammatory cytokine-stimulated, cultured normal human astrocytes is mediated by MEK-ERK kinases.
Topics: Astrocytes; Biopterins; Butadienes; Cells, Cultured; Cytokines; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Proto-Oncogene Proteins c-raf; Tumor Necrosis Factor-alpha | 2005 |
Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors.
Topics: Allosteric Site; Animals; Antioxidants; Biopterins; Blotting, Western; Bronchi; Cell Line; Cell Line, Tumor; Cytokines; Dimerization; Down-Regulation; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Lung; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Biosynthesis; Protein Isoforms; Protein Processing, Post-Translational; Rabbits; Reticulocytes; Time Factors; Transcription, Genetic | 2004 |