sapropterin has been researched along with Hyperglycemia in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, H; El-Daly, M; Hirota, SA; Hollenberg, MD; Pulakazhi Venu, VK; Saifeddine, M; Triggle, CR | 1 |
| Bienengraeber, M; Ge, ZD; Kersten, JR; Leucker, TM; Liu, Y; Procknow, J; Shi, Y; Warltier, DC | 1 |
| Amour, J; Brzezinska, AK; Du, J; Jager, Z; Kersten, JR; Pratt, PF; Shi, Y; Sullivan, C; Vladic, N; Warltier, DC; Weihrauch, D | 1 |
| Ding, H; Triggle, CR | 1 |
| Ge, ZD; Hirata, N; Ionova, IA; Kersten, JR; Pieper, GM; Pratt, PF; Pravdic, D; Vásquez-Vivar, J; Vladic, N; Warltier, DC | 1 |
| Brzezinska, AK; Du, JH; Ge, ZD; Kersten, JR; Leucker, T; Pratt, PF; Shi, Y; Vladic, N; Warltier, DC | 1 |
| Chen, J; Tan, Z; Wang, J; Zhu, M | 1 |
| Dominguez, H; Hermann, T; Ihlemann, N; Køber, L; Perner, A; Rask-Madsen, C; Torp-Pedersen, C | 1 |
| Cai, S; Channon, KM; Khoo, J | 1 |
| Assaloni, R; Ceriello, A; Da Ros, R; Piconi, L; Quagliaro, L; Szabó, C | 1 |
| Ding, QF; Hattori, Y; Hayashi, T; Iguchi, A; Miyazaki-Akita, A; Nomura, T; Shiraishi, H | 1 |
1 review(s) available for sapropterin and Hyperglycemia
| Article | Year |
|---|---|
Endothelial dysfunction in diabetes: multiple targets for treatment.
Topics: Animals; Biological Factors; Biopterins; Blood Glucose; Calcium; Cell Communication; Connexins; Diabetes Mellitus; Diabetic Angiopathies; Dyslipidemias; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Nitric Oxide Synthase Type III; Oxidative Stress; Transient Receptor Potential Channels | 2010 |
1 trial(s) available for sapropterin and Hyperglycemia
| Article | Year |
|---|---|
Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects.
Topics: Administration, Oral; Antioxidants; Biopterins; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Free Radical Scavengers; Glucose; Heart Rate; Humans; Hyperglycemia; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-N-Methylarginine; Postprandial Period; Regional Blood Flow; Serotonin; Vasodilation | 2003 |
9 other study(ies) available for sapropterin and Hyperglycemia
| Article | Year |
|---|---|
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
Topics: Biomarkers; Biopterins; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Incidence; Isothiocyanates; Oxidative Stress; Prognosis; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sulfoxides | 2019 |
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury.
Topics: Animals; Biopterins; Cell Communication; Disease Susceptibility; Endothelial Cells; Glucose; Hyperglycemia; Male; Mice; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Multimerization; Protein Structure, Quaternary; Pterins; Rats; Reperfusion Injury | 2013 |
Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms.
Topics: Anesthetics; Animals; Biopterins; Blotting, Western; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelial Cells; Enzyme Activation; Glucose; Hemodynamics; HSP90 Heat-Shock Proteins; Humans; Hyperglycemia; Ischemic Preconditioning, Myocardial; Isoflurane; Luminescence; Male; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Rabbits; Ventricular Function, Left | 2010 |
Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia.
Topics: Analysis of Variance; Animals; Biopterins; Calcium; Disease Models, Animal; Enzyme Inhibitors; GTP Cyclohydrolase; Humans; Hyperglycemia; Ischemic Preconditioning, Myocardial; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction; Time Factors; Ultrasonography; Ventricular Function, Left | 2011 |
Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Topics: Animals; Benzoquinones; Biopterins; Blood Glucose; Blotting, Western; Cells, Cultured; Coronary Occlusion; Disease Models, Animal; Endothelial Cells; HSP90 Heat-Shock Proteins; Hyperglycemia; Immunoprecipitation; Ischemic Preconditioning, Myocardial; Lactams, Macrocyclic; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Multimerization; Pterins; Rabbits; Time Factors | 2011 |
Propofol protects against high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells.
Topics: Anesthetics, Intravenous; Antioxidants; Biopterins; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glucose; GTP Cyclohydrolase; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Mass Spectrometry; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Propofol; Protein Multimerization; Superoxides; Time Factors | 2012 |
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
Topics: Adenoviridae; Aorta; Biopterins; Cells, Cultured; Dimerization; Endothelium, Vascular; Gene Transfer Techniques; Genetic Vectors; GTP Cyclohydrolase; Humans; Hyperglycemia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Superoxides | 2005 |
Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Apoptosis; Biopterins; Caspase 3; Cells, Cultured; Deoxyguanosine; Endothelial Cells; Glucose; Humans; Hyperglycemia; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-bcl-2; Superoxides; Thenoyltrifluoroacetone; Tyrosine | 2007 |
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
Topics: Animals; Biopterins; Cardiovascular Diseases; Cattle; Cells, Cultured; Diabetes Complications; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Receptor alpha; Female; GTP Cyclohydrolase; Hyperglycemia; Nitric Oxide Synthase Type III; Nitrites; Postmenopause; Protein Kinase C; RNA, Small Interfering | 2007 |