sapropterin has been researched along with Elevated Cholesterol in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 13 (68.42) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Ding, ML; Duan, SZ; He, W; Li, J; Tao, J; Wu, F; Xia, WH; Xie, WL; Zhang, XY | 1 |
| Fuenzalida, B; Gutiérrez, J; Leiva, A; Pardo, F; Salomón, C; Sanhueza, C; Sobrevia, L; Toledo, F; Westermeier, F | 1 |
| Bryan, NS; Dugas, TR; Garg, H; Guidry, E; Stokes, KY; Tang, Y | 1 |
| Giddings, JC; Goto, M; Ijiri, Y; Inoue, A; Kawashima, S; Naemura, A; Seki, J; Shinohara, M; Tamura, Y; Yada, T; Yamamoto, J | 1 |
| Holowatz, LA; Kenney, WL | 1 |
| Alexander, LM; Kenney, WL; Kutz, JL | 1 |
| Brooks, RM; Castaneda, LE; Chu, Y; Heistad, DD; Miller, JD; Serrano, KM | 1 |
| Blau, N; Thöny, B | 1 |
| Alp, NJ; Channon, KM | 1 |
| Kawashima, S; Yokoyama, M | 1 |
| Camici, PG; Kaufmann, PA; Koepfli, P; Luscher, TF; Namdar, M; Siegrist, PT; Wyss, CA | 1 |
| Bolli, R; Dawn, B; Kodani, E; Sato, H; Shirk, G; Takano, H; Tang, XL; Wu, WJ; Xuan, YT; Zhu, Y | 1 |
| Corti, R; Flammer, A; Hermann, F; Lüscher, TF; Noll, G; Spieker, LE; Sudano, I | 1 |
| Hattori, S; Hattori, Y; Kasai, K; Nakanishi, N; Satoh, H; Wang, X | 1 |
| Alp, NJ; Blau, N; Channon, KM; Chenevard, R; Cosentino, F; Delli Gatti, C; Enseleit, F; Eto, M; Hürlimann, D; Lerch, P; Lüscher, TF; Noll, G; Ruschitzka, F; Volpe, M | 1 |
| Cosentino, F; Erkelens, W; Kastelein, J; Koomans, H; Lüscher, T; Rabelink, T; Stroes, E; Wever, R | 1 |
| Tiefenbacher, CP | 1 |
| Dumont, AS; Maitland, A; Verma, S | 1 |
| Chayama, K; Fukuda, Y; Matsuda, K; Matsuura, H; Teragawa, H; Yamagata, T | 1 |
4 review(s) available for sapropterin and Elevated Cholesterol
| Article | Year |
|---|---|
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
Topics: Animals; Arginine; Biopterins; Borohydrides; Cholesterol; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy | 2015 |
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Topics: Animals; Biological Availability; Biopterins; Coenzymes; Diabetes Mellitus; Enzyme Induction; GTP Cyclohydrolase; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Mutant Strains; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pterins; Rabbits; Rats; Rats, Inbred Strains; Superoxides; Vascular Diseases | 2004 |
Dysfunction of endothelial nitric oxide synthase and atherosclerosis.
Topics: Animals; Antioxidants; Arteriosclerosis; Biopterins; Endothelium, Vascular; Enzyme Induction; Humans; Hypercholesterolemia; Mice; Mice, Knockout; Mice, Transgenic; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rabbits; Recombinant Fusion Proteins; Risk Factors; Stress, Mechanical; Superoxides | 2004 |
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Atherosclerosis; Biopterins; Cacao; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dyslipidemias; Endothelin-1; Endothelins; Endothelium, Vascular; Flavonoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, HDL; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species | 2006 |
4 trial(s) available for sapropterin and Elevated Cholesterol
| Article | Year |
|---|---|
Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans.
Topics: Anticholesteremic Agents; Arginase; Arginine; Atorvastatin; Biopterins; Cholesterol; Female; Heating; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoproteins, LDL; Male; Microcirculation; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Regional Blood Flow; Skin; Vasodilation | 2011 |
Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia.
Topics: Adult; Antioxidants; Biopterins; Blood Flow Velocity; Exercise Test; Humans; Hypercholesterolemia; Infusions, Intravenous; Male; Microcirculation; Middle Aged; Radionuclide Imaging; Recovery of Function; Treatment Outcome | 2005 |
Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
Topics: Administration, Oral; Adult; Aged; Biopterins; Cells, Cultured; Cholesterol, LDL; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; Female; Forearm; Humans; Hypercholesterolemia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Plethysmography; Regional Blood Flow; Superoxides; Vasodilation | 2008 |
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
Topics: Adult; Antioxidants; Arginine; Biopterins; Endothelium; Female; Forearm; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Plethysmography; Serotonin; Vasoconstriction; Vasodilation | 1997 |
11 other study(ies) available for sapropterin and Elevated Cholesterol
| Article | Year |
|---|---|
Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling.
Topics: Animals; Biopterins; Blood Pressure; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Vascular; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Nude; Nitric Oxide Synthase; Oxidative Stress; Retrospective Studies; Vasodilation | 2016 |
Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Biopterins; Blood Pressure; C-Reactive Protein; Cholesterol, Dietary; Diet; Disease Models, Animal; Endothelium, Vascular; Hypercholesterolemia; Inflammation; Leukocyte Rolling; Liver; Male; Mice; Mice, Inbred C57BL; Microvessels; Myocardium; Nitric Oxide; Sodium Nitrite; Triglycerides; Vasodilation; Vasodilator Agents | 2009 |
Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic/atherogenic mice.
Topics: Animals; Aorta; Biopterins; Endothelium, Vascular; Femoral Artery; Hypercholesterolemia; Male; Mice; Mice, Knockout; Nitric Oxide; Regional Blood Flow; Vasodilation | 2009 |
Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms.
Topics: Administration, Cutaneous; Adult; Aged; Analysis of Variance; Antioxidants; Biopterins; Case-Control Studies; Cholesterol; Enzyme Inhibitors; Female; Humans; Hypercholesterolemia; Laser-Doppler Flowmetry; Male; Microdialysis; Microvessels; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Regional Blood Flow; Skin; Time Factors; Vasodilation; Vasodilator Agents | 2013 |
Vascular function during prolonged progression and regression of atherosclerosis in mice.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Biopterins; Carrier Proteins; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Gene Expression Regulation; Hypercholesterolemia; Immunohistochemistry; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Pterins; Receptors, LDL; Tetrahydrofolate Dehydrogenase; Time Factors; Vasodilation; Vasodilator Agents | 2013 |
Possible impact of tetrahydrobiopterin and sepiapterin on endothelial dysfunction.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Blood Vessels; Coronary Disease; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypercholesterolemia; Nitric Oxide Synthase; Pterins; Rabbits; Species Specificity | 2003 |
Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits.
Topics: Animals; Biopterins; Cholesterol, Dietary; Consciousness; Coronary Circulation; Disease Models, Animal; Hypercholesterolemia; Ischemic Preconditioning; Myocardial Ischemia; Rabbits | 2005 |
Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice.
Topics: Administration, Oral; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biopterins; Disease Progression; Endothelium, Vascular; Hypercholesterolemia; Immunohistochemistry; Inflammation Mediators; Mice; Mice, Knockout; RNA, Messenger; Superoxides | 2007 |
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin.
Topics: Animals; Biopterins; Cholesterol; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin-1; Hypercholesterolemia; Superoxides; Swine | 2001 |
Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia.
Topics: Acetylcholine; Aged; Antioxidants; Biopterins; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypercholesterolemia; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Middle Aged; Nitroglycerin; omega-N-Methylarginine; Vasodilator Agents | 2002 |