sapropterin has been researched along with Disease Exacerbation in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonçalves, DA; Jasiulionis, MG; Melo, FHM | 1 |
| Al Haj Zen, A; Channon, KM; Chuaiphichai, S; Crabtree, MJ; Douglas, G; Hale, AB; McNeill, E; Patel, J; Rashbrook, VS; Trelfa, L | 1 |
| Arellano-Mendoza, M; Cruz-Laguna, E; Escalante, B; Gámez-Méndez, AM; Rios, A; Vargas-Robles, H | 1 |
| Burton, BK; Dimmock, D; Feigenbaum, A; Jurecki, E; Lang, W; Longo, N; Prasad, S; Siriwardena, K; Stockler, S; Waisbren, S; Zhang, C | 1 |
| Alam, A; Cardnell, RJ; Graves, P; Mikkelsen, RB; Mukhopadhyay, ND; Rabender, CS; Sundaresan, G; Yakovlev, VA; Zweit, J | 1 |
| Alp, NJ; Channon, KM; Cheng, A; Crabtree, MJ; Douglas, G; Hale, AB; Khoo, J; McNeill, E; O'Neill, CA; Schmidt, TS | 1 |
| Carnicer, R; Casadei, B; Crabtree, MJ; Kass, DA; Sivakumaran, V | 1 |
| Hattori, S; Hattori, Y; Kasai, K; Nakanishi, N; Satoh, H; Wang, X | 1 |
| Alp, NJ; Schmidt, TS | 1 |
| Arruda, P; Castro, GM; de Nucci, G; Langone, F; Martins, ML; Muscará, MN; Papes, F; Rogério, F; Santos, LM; Teixeira, SA | 1 |
3 review(s) available for sapropterin and Disease Exacerbation
| Article | Year |
|---|---|
The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin.
Topics: Animals; Biopterins; Disease Progression; Humans; Neoplasms; Nitric Oxide Synthase | 2021 |
Nitric oxide synthases in heart failure.
Topics: Animals; Arginase; Autocrine Communication; Biopterins; Calcium Signaling; Cyclic GMP; Diabetes Mellitus; Disease Progression; Enzyme Activation; Enzyme Induction; Heart Diseases; Heart Failure; Humans; Hypertension; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Paracrine Communication; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Signal Transduction; Superoxides | 2013 |
Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.
Topics: Animals; Ascorbic Acid; Atherosclerosis; Biopterins; Disease Progression; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Reactive Oxygen Species; Vitamins | 2007 |
1 trial(s) available for sapropterin and Disease Exacerbation
| Article | Year |
|---|---|
Long-term developmental progression in infants and young children taking sapropterin for phenylketonuria: a two-year analysis of safety and efficacy.
Topics: Biopterins; Child; Child Development; Child, Preschool; Cognition; Disease Progression; Female; Humans; Infant; Infant, Newborn; Male; Phenylalanine; Phenylketonurias; Prospective Studies; Time Factors; Treatment Outcome | 2015 |
6 other study(ies) available for sapropterin and Disease Exacerbation
| Article | Year |
|---|---|
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Biopterins; Blood Pressure; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Foam Cells; GTP Cyclohydrolase; Macrophages; Male; Mice, Knockout, ApoE; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Plaque, Atherosclerotic; Reactive Oxygen Species; Vascular Cell Adhesion Molecule-1; Vasoconstriction; Vasodilation | 2018 |
Early stage of obesity potentiates nitric oxide reduction during the development of renal failure.
Topics: Animals; Antioxidants; Biomarkers; Biopterins; Diet, High-Fat; Disease Models, Animal; Disease Progression; Down-Regulation; Kidney; Male; Mice, Inbred C57BL; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Oxidative Stress; Proteinuria; Reactive Oxygen Species; Renal Insufficiency; Risk Factors; RNA, Messenger; Weight Gain | 2014 |
The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Biopterins; Cell Line, Tumor; Cyclic GMP-Dependent Protein Kinases; Disease Progression; Heterografts; Humans; Mice, Nude; Neoplasms; NF-kappa B; Nitric Oxide Synthase; Peroxynitrous Acid; Pterins; Superoxides; Transcription Factor 4; Transcription Factors | 2015 |
Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
Topics: Administration, Oral; Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biopterins; Chemotaxis, Leukocyte; Disease Progression; Drug Administration Schedule; Drug Evaluation, Preclinical; Endothelium, Vascular; Hemodynamics; Lipids; Male; Mice; Mice, Knockout; RNA, Messenger; Tissue Distribution; Vascular Cell Adhesion Molecule-1 | 2010 |
Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice.
Topics: Administration, Oral; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biopterins; Disease Progression; Endothelium, Vascular; Hypercholesterolemia; Immunohistochemistry; Inflammation Mediators; Mice; Mice, Knockout; RNA, Messenger; Superoxides | 2007 |
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Topics: Animals; Biopterins; Brain; Calcium; Calmodulin; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Flavin-Adenine Dinucleotide; Male; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Inbred Lew; RNA, Messenger; Subcellular Fractions; Tyrosine | 2002 |