sapropterin has been researched along with Diabetes Mellitus in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, KI; Cho, SW; Ha, NC; Han, J; Heo, HJ; Jeong, SH; Jeong, YJ; Kha, PT; Kim, HK; Kim, M; Kim, N; Kim, SW; Ko, KS; Ko, TH; Lee, SR; Minamino, T; Nilius, B; Park, NM; Park, YS; Rhee, BD; Seo, DY; Shimizu, I; Song, IS; Won, JC; Youm, JB | 1 |
| Li, XJ; Tie, L; Wang, ZF | 1 |
| Akbari, AA; Epane, EC; Gangula, PR; Halpern, L; Obi, N; Southerland, JH; Stewart, CR | 1 |
| Ding, H; Triggle, CR | 1 |
| Carnicer, R; Casadei, B; Crabtree, MJ; Kass, DA; Sivakumaran, V | 1 |
| Hoang, HH; Meininger, CJ; Padgham, SV | 1 |
| Anderson, T; Pannirselvam, M; Simon, V; Triggle, CR; Verma, S | 1 |
| Alp, NJ; Channon, KM | 1 |
| Gorren, AC; Heller, R; Mayer, B; Werner, ER; Werner-Felmayer, G | 1 |
| Bauersachs, J; Schäfer, A | 1 |
| Ren, J; Wu, S | 1 |
| Kass, DA; Moens, AL | 1 |
| Holden, RJ; Mooney, PA | 1 |
| Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G | 1 |
| Channon, KM; Gastaldi, D; Guzik, TJ; Mussa, S; Pillai, R; Ratnatunga, C; Sadowski, J | 1 |
8 review(s) available for sapropterin and Diabetes Mellitus
| Article | Year |
|---|---|
[Tetrahydrobiopterin Synthesis and Biological Function].
Topics: Antioxidants; Biopterins; Diabetes Mellitus; Heart; Humans; Hypertension, Pulmonary; Nitric Oxide Synthase; Nitric Oxide Synthase Type III | 2015 |
Endothelial dysfunction in diabetes: multiple targets for treatment.
Topics: Animals; Biological Factors; Biopterins; Blood Glucose; Calcium; Cell Communication; Connexins; Diabetes Mellitus; Diabetic Angiopathies; Dyslipidemias; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Nitric Oxide Synthase Type III; Oxidative Stress; Transient Receptor Potential Channels | 2010 |
Nitric oxide synthases in heart failure.
Topics: Animals; Arginase; Autocrine Communication; Biopterins; Calcium Signaling; Cyclic GMP; Diabetes Mellitus; Disease Progression; Enzyme Activation; Enzyme Induction; Heart Diseases; Heart Failure; Humans; Hypertension; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Paracrine Communication; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Signal Transduction; Superoxides | 2013 |
L-arginine, tetrahydrobiopterin, nitric oxide and diabetes.
Topics: Arginine; Biomarkers; Biopterins; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tetrahydrofolate Dehydrogenase | 2013 |
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Topics: Animals; Biological Availability; Biopterins; Coenzymes; Diabetes Mellitus; Enzyme Induction; GTP Cyclohydrolase; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Mutant Strains; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pterins; Rabbits; Rats; Rats, Inbred Strains; Superoxides; Vascular Diseases | 2004 |
Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects.
Topics: Allosteric Regulation; Animals; Ascorbic Acid; Biopterins; Catalysis; Diabetes Mellitus; Electron Transport; Endothelium, Vascular; Enzyme Inhibitors; Humans; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Vasodilation | 2003 |
A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction?
Topics: Animals; Biopterins; Cytokines; Diabetes Mellitus; Endothelin-1; Heart Diseases; Humans; Inflammation; Insulin Resistance; Myocardium; Nitric Oxide; Sepsis; Shock, Septic; Systemic Inflammatory Response Syndrome; Toll-Like Receptors | 2006 |
Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease.
Topics: Animals; Biopterins; Cardiovascular Agents; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Folic Acid; Humans; Nitric Oxide Synthase | 2007 |
7 other study(ies) available for sapropterin and Diabetes Mellitus
| Article | Year |
|---|---|
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes.
Topics: AMP-Activated Protein Kinases; Animals; Biopterins; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus; Diabetic Cardiomyopathies; Heart; Male; Mice; Mice, Inbred C57BL; Mitochondria; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Organelle Biogenesis; Oxidative Phosphorylation; Rats; Rats, Long-Evans; Signal Transduction | 2020 |
Effects of Diabetes on Salivary Gland Protein Expression of Tetrahydrobiopterin and Nitric Oxide Synthesis and Function.
Topics: Animals; Biopterins; Diabetes Complications; Diabetes Mellitus; Female; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Salivary Proteins and Peptides; Xerostomia | 2016 |
Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice.
Topics: Acetylcholine; Administration, Oral; Animals; Biopterins; Diabetes Mellitus; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelium, Vascular; GTP Cyclohydrolase; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Inferior; Mice; Mice, Inbred C57BL; Neopterin; Oxidative Stress; Phenylephrine; Pterins; Vasoconstriction; Vasodilation | 2003 |
Tetrahydrobiopterin and eNOS dimer/monomer ratio--a clue to eNOS uncoupling in diabetes?
Topics: Animals; Biopterins; Diabetes Mellitus; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III | 2005 |
Interleukin-1 beta: a common cause of Alzheimer's disease and diabetes mellitus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Biopterins; Cytokines; Diabetes Mellitus; Humans; Hypoglycemia; Insulin; Interleukin-1; Models, Biological; Neurofibrillary Tangles | 1995 |
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains | 2000 |
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Topics: Biopterins; Blood Vessels; Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Mammary Arteries; Membrane Transport Proteins; Middle Aged; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoproteins; Protein Kinase C; Saphenous Vein; Signal Transduction; Superoxides | 2002 |