sapropterin has been researched along with Diabetes Mellitus, Type 2 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Nimer, M; Mahwi, T; Ratha, R | 1 |
| Ding, H; El-Daly, M; Hirota, SA; Hollenberg, MD; Pulakazhi Venu, VK; Saifeddine, M; Triggle, CR | 1 |
| Cai, H; Youn, JY; Zhou, J | 1 |
| Baumgardt, SL; Bosnjak, ZJ; Fang, J; Ge, ZD; Kersten, JR; Leucker, TM; Paterson, M; Warltier, DC; Zhang, DX | 1 |
| Böhm, F; Channon, KM; Malmström, RE; Pernow, J; Settergren, M | 1 |
| Edwards, JG; Grijalva, J; Hicks, S; Kaminski, PM; Medikayala, S; Wolin, MS; Zhao, X | 1 |
| Del Valle-Mondragon, L; Escalante-Acosta, BA; Lozano-Nuevo, JJ; Rubio-Guerra, AF; Vargas-Robles, H | 1 |
| Imanishi, M; Kitabayashi, C; Konishi, Y; Maeda, I; Masada, M; Morikawa, T; Nishiyama, A; Okada, N; Shirahashi, N; Wilcox, CS | 1 |
| Nygren, A; Nyström, T; Sjöholm, A | 1 |
| Al-Mulla, F; Al-Saleh, E; Bitar, MS; Dhaunsi, GS; Mustafa, S; Wahid, S | 1 |
| Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L | 1 |
| Hosoi, M; Imanishi, M; Konishi, Y; Masada, M; Miura, K; Morikawa, T; Okada, N; Okumura, M; Shintaku, H; Yoshida, Y | 1 |
| Crabtree, MJ; Goligorsky, MS; Gross, SS; Lam, G; Smith, CL | 1 |
| Bauersachs, J; Thum, T | 1 |
| Albers, S; Heitzer, T; Krohn, K; Meinertz, T | 1 |
| Anderson, TJ; Pannirselvam, M; Triggle, CR; Verma, S | 1 |
3 trial(s) available for sapropterin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Arginine; Biopterins; Blood Flow Velocity; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Reperfusion Injury; Treatment Outcome; Vasodilation; Vasodilator Agents | 2009 |
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan | 2013 |
Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.
Topics: Biopterins; Blood Glucose; Coenzymes; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Vasodilation | 2004 |
13 other study(ies) available for sapropterin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations.
Topics: Adult; Biomarkers; Biopterins; Blood Sedimentation; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Foot; Erythrocyte Indices; Female; Humans; Male; Mean Platelet Volume; Metabolic Networks and Pathways; Middle Aged; Multivariate Analysis; Neopterin; Nitric Oxide | 2019 |
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
Topics: Biomarkers; Biopterins; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Incidence; Isothiocyanates; Oxidative Stress; Prognosis; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sulfoxides | 2019 |
Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.
Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Glucose; Bone Morphogenetic Protein 4; Carrier Proteins; Cattle; Cells, Cultured; Cholesterol; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Inflammation; Male; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type III; RNA, Small Interfering; Superoxides | 2015 |
Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.
Topics: Age Factors; Animals; Biopterins; Cardiotonic Agents; Cells, Cultured; Citrulline; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Isolated Heart Preparation; Mice, Inbred C57BL; Mice, Obese; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Protein Multimerization; Pterins; Time Factors; Vasodilation; Ventricular Function, Left | 2016 |
Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats.
Topics: Animals; Biopterins; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Physical Conditioning, Animal; Rats; Rats, Inbred Strains; Reactive Oxygen Species; RNA, Messenger; Superoxides | 2008 |
Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins.
Topics: Aged; Biopterins; Blood Pressure; Diabetes Mellitus, Type 2; E-Selectin; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Solubility; Vascular Cell Adhesion Molecule-1 | 2012 |
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2005 |
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine | 2006 |
Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.
Topics: Animals; Biopterins; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nitric Oxide; Proteinuria; Rats; Rats, Inbred OLETF; Rats, Long-Evans | 2006 |
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
Topics: Animals; Biopterins; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Glucose; Glutathione; Mice; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Binding; Rats; Rats, Zucker; Superoxides; Time Factors; Tritium | 2008 |
Letter by Thum et al regarding article, "Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist
Topics: Biopterins; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; Humans; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; PPAR gamma; Rosiglitazone; Stem Cells; Thiazolidinediones; Vasodilator Agents | 2008 |
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus.
Topics: Acetylcholine; Biopterins; Blood Flow Velocity; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Plethysmography; Vasodilation; Vasodilator Agents | 2000 |
Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability.
Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Cell Surface; Receptors, Leptin; Vasodilation | 2002 |