Page last updated: 2024-08-21

sapropterin and Diabetes Mellitus, Type 2

sapropterin has been researched along with Diabetes Mellitus, Type 2 in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (62.50)29.6817
2010's6 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Al-Nimer, M; Mahwi, T; Ratha, R1
Ding, H; El-Daly, M; Hirota, SA; Hollenberg, MD; Pulakazhi Venu, VK; Saifeddine, M; Triggle, CR1
Cai, H; Youn, JY; Zhou, J1
Baumgardt, SL; Bosnjak, ZJ; Fang, J; Ge, ZD; Kersten, JR; Leucker, TM; Paterson, M; Warltier, DC; Zhang, DX1
Böhm, F; Channon, KM; Malmström, RE; Pernow, J; Settergren, M1
Edwards, JG; Grijalva, J; Hicks, S; Kaminski, PM; Medikayala, S; Wolin, MS; Zhao, X1
Del Valle-Mondragon, L; Escalante-Acosta, BA; Lozano-Nuevo, JJ; Rubio-Guerra, AF; Vargas-Robles, H1
Imanishi, M; Kitabayashi, C; Konishi, Y; Maeda, I; Masada, M; Morikawa, T; Nishiyama, A; Okada, N; Shirahashi, N; Wilcox, CS1
Nygren, A; Nyström, T; Sjöholm, A1
Al-Mulla, F; Al-Saleh, E; Bitar, MS; Dhaunsi, GS; Mustafa, S; Wahid, S1
Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L1
Hosoi, M; Imanishi, M; Konishi, Y; Masada, M; Miura, K; Morikawa, T; Okada, N; Okumura, M; Shintaku, H; Yoshida, Y1
Crabtree, MJ; Goligorsky, MS; Gross, SS; Lam, G; Smith, CL1
Bauersachs, J; Thum, T1
Albers, S; Heitzer, T; Krohn, K; Meinertz, T1
Anderson, TJ; Pannirselvam, M; Triggle, CR; Verma, S1

Trials

3 trial(s) available for sapropterin and Diabetes Mellitus, Type 2

ArticleYear
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
    Atherosclerosis, 2009, Volume: 204, Issue:1

    Topics: Aged; Arginine; Biopterins; Blood Flow Velocity; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Reperfusion Injury; Treatment Outcome; Vasodilation; Vasodilator Agents

2009
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan

2013
Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:5

    Topics: Biopterins; Blood Glucose; Coenzymes; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Vasodilation

2004

Other Studies

13 other study(ies) available for sapropterin and Diabetes Mellitus, Type 2

ArticleYear
Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations.
    Journal of diabetes research, 2019, Volume: 2019

    Topics: Adult; Biomarkers; Biopterins; Blood Sedimentation; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Foot; Erythrocyte Indices; Female; Humans; Male; Mean Platelet Volume; Metabolic Networks and Pathways; Middle Aged; Multivariate Analysis; Neopterin; Nitric Oxide

2019
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
    Canadian journal of diabetes, 2019, Volume: 43, Issue:7

    Topics: Biomarkers; Biopterins; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Incidence; Isothiocyanates; Oxidative Stress; Prognosis; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sulfoxides

2019
Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.
    Molecular endocrinology (Baltimore, Md.), 2015, Volume: 29, Issue:8

    Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Glucose; Bone Morphogenetic Protein 4; Carrier Proteins; Cattle; Cells, Cultured; Cholesterol; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Inflammation; Male; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type III; RNA, Small Interfering; Superoxides

2015
Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.
    Circulation. Heart failure, 2016, Volume: 9, Issue:1

    Topics: Age Factors; Animals; Biopterins; Cardiotonic Agents; Cells, Cultured; Citrulline; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Isolated Heart Preparation; Mice, Inbred C57BL; Mice, Obese; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Protein Multimerization; Pterins; Time Factors; Vasodilation; Ventricular Function, Left

2016
Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats.
    Cardiovascular diabetology, 2008, Nov-19, Volume: 7

    Topics: Animals; Biopterins; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Physical Conditioning, Animal; Rats; Rats, Inbred Strains; Reactive Oxygen Species; RNA, Messenger; Superoxides

2008
Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins.
    Endocrine, metabolic & immune disorders drug targets, 2012, Volume: 12, Issue:3

    Topics: Aged; Biopterins; Blood Pressure; Diabetes Mellitus, Type 2; E-Selectin; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Solubility; Vascular Cell Adhesion Molecule-1

2012
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
    European journal of pharmacology, 2005, Mar-21, Volume: 511, Issue:1

    Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents

2005
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
    Circulation research, 2006, Jul-07, Volume: 99, Issue:1

    Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine

2006
Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.
    Kidney international, 2006, Volume: 70, Issue:3

    Topics: Animals; Biopterins; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nitric Oxide; Proteinuria; Rats; Rats, Inbred OLETF; Rats, Long-Evans

2006
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4

    Topics: Animals; Biopterins; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Glucose; Glutathione; Mice; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Binding; Rats; Rats, Zucker; Superoxides; Time Factors; Tritium

2008
Letter by Thum et al regarding article, "Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist
    Circulation, 2008, Mar-11, Volume: 117, Issue:10

    Topics: Biopterins; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; Humans; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; PPAR gamma; Rosiglitazone; Stem Cells; Thiazolidinediones; Vasodilator Agents

2008
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus.
    Diabetologia, 2000, Volume: 43, Issue:11

    Topics: Acetylcholine; Biopterins; Blood Flow Velocity; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Plethysmography; Vasodilation; Vasodilator Agents

2000
Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability.
    British journal of pharmacology, 2002, Volume: 136, Issue:2

    Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Cell Surface; Receptors, Leptin; Vasodilation

2002