Page last updated: 2024-08-21

sapropterin and Coronary Disease

sapropterin has been researched along with Coronary Disease in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (81.82)	29.6817
2010's	2 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Shen, S; Tian, Y; Wang, B; Wang, C; Zhang, S	1
Kietadisorn, R; Kietselaer, BL; Moens, AL; Schmidt, HH	1
Blau, N; Thöny, B	1
Nygren, A; Nyström, T; Sjöholm, A	1
McCarty, MF	1
Cosentino, F; Fleisch, M; Hess, OM; Lüscher, TF; Lütolf, RB; Maier, W; Meier, B; Seiler, C	1
Blau, N; Kierat, L; Reinhart, WH; Schoedon, G; Walter, R	1
Doshi, SN; Goodfellow, J; Kredan, MB; Lang, D; Lewis, MJ; McDowell, IF; Moat, SJ; Newcombe, RG	1
Mohri, M; Setoguchi, S; Shimokawa, H; Takeshita, A	1
Dumont, AS; Maitland, A; Verma, S	1
Hirayama, A; Kashiwagi, A; Kikkawa, R; Kodama, K; Masada, M; Nishio, Y; Ohtani, T; Okamura, T; Shinozaki, K; Yoshida, Y	1

Trials

2 trial(s) available for sapropterin and Coronary Disease

Article	Year
Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:5 Topics: Biopterins; Blood Glucose; Coenzymes; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Vasodilation	2004
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide? Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:7 Topics: Animals; Biopterins; Cells, Cultured; Coronary Disease; Cross-Over Studies; Cytoplasm; Dietary Supplements; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Superoxides; Tetrahydrofolates	2001

Article

Year

Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.

American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:5

Topics: Biopterins; Blood Glucose; Coenzymes; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Vasodilation

2004

Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?

Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:7

Topics: Animals; Biopterins; Cells, Cultured; Coronary Disease; Cross-Over Studies; Cytoplasm; Dietary Supplements; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Superoxides; Tetrahydrofolates

2001

Other Studies

9 other study(ies) available for sapropterin and Coronary Disease

Article	Year
Effects of simulated heat waves on ApoE-/- mice. International journal of environmental research and public health, 2014, Jan-28, Volume: 11, Issue:2 Topics: Animals; Atherosclerosis; Biomarkers; Biopterins; Body Temperature; Body Weight; Coronary Disease; Drug Evaluation, Preclinical; Endothelin-1; Extreme Heat; Infrared Rays; Male; Mice; Mice, Knockout; Nitric Oxide; Random Allocation; Superoxide Dismutase	2014
Role of tetrahydrobiopterin (BH4) in hyperhomocysteinemia-induced endothelial dysfuction: new indication for this orphan-drug? American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:6 Topics: Biopterins; Coronary Circulation; Coronary Disease; Coronary Vessels; Endothelium, Vascular; Humans; Hyperhomocysteinemia; Nitric Oxide; Orphan Drug Production; Oxidation-Reduction; Ultrasonography; Vascular Diseases	2011
Possible impact of tetrahydrobiopterin and sepiapterin on endothelial dysfunction. Arteriosclerosis, thrombosis, and vascular biology, 2003, May-01, Volume: 23, Issue:5 Topics: Alcohol Oxidoreductases; Animals; Biopterins; Blood Vessels; Coronary Disease; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypercholesterolemia; Nitric Oxide Synthase; Pterins; Rabbits; Species Specificity	2003
Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite. Medical hypotheses, 2007, Volume: 69, Issue:6 Topics: Animals; Biopterins; Clinical Trials as Topic; Coronary Disease; Diet; Endothelium; gamma-Tocopherol; Humans; Models, Biological; Models, Theoretical; Nuts; Peroxynitrous Acid; Risk	2007
Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2 Topics: Acetylcholine; Adenosine; Aged; Angiography; Antioxidants; Biopterins; Coronary Disease; Coronary Vessels; Drug Interactions; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitroglycerin; Vasoconstriction; Vasodilator Agents	2000
Systemic tetrahydrobiopterin (BH4) levels and coronary artery disease. Cardiology, 2000, Volume: 94, Issue:4 Topics: Antioxidants; Biopterins; Coronary Disease; Endothelium, Vascular; Humans	2000
Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease. Journal of the American College of Cardiology, 2001, Volume: 38, Issue:2 Topics: Acetylcholine; Adult; Aged; Biopterins; Coronary Circulation; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Hemodynamics; Humans; Male; Microcirculation; Middle Aged; Pericardium; Vasodilation	2001
Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin. Heart (British Cardiac Society), 2001, Volume: 86, Issue:6 Topics: Animals; Biopterins; Cholesterol; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin-1; Hypercholesterolemia; Superoxides; Swine	2001
Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. Journal of the American College of Cardiology, 2001, Volume: 38, Issue:7 Topics: Acetylcholine; Aged; Biopterins; Coronary Circulation; Coronary Disease; Dihydropteridine Reductase; Endothelium, Vascular; Erythrocytes; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Lipid Peroxides; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Reference Values; Risk Factors	2001