sapropterin has been researched along with Cardiovascular Diseases in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (32.43) | 29.6817 |
| 2010's | 23 (62.16) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SJ; Jeon, BH; Kim, CS; Kim, S; Lee, I; Nagar, H; Piao, S | 1 |
| Han, J; Kim, HK | 1 |
| Daiber, A; Münzel, T | 1 |
| Ng, GA; Ng, LL; Yuyun, MF | 1 |
| Ding, H; El-Daly, M; Hirota, SA; Hollenberg, MD; Pulakazhi Venu, VK; Saifeddine, M; Triggle, CR | 1 |
| Hussein, D; Nandi, M; Starr, A | 1 |
| Cottin, Y; Guilland, JC; Lorin, J; Rochette, L; Vergely, C; Zeller, M | 1 |
| Chen, AF; Chen, DD; Chen, LY; Shu, C; Xie, JB; Yang, T; Yuan, H; Zhou, S | 1 |
| Bendall, JK; Channon, KM; Crabtree, MJ; Douglas, G; McNeill, E | 1 |
| Lykkesfeldt, J; Mortensen, A | 1 |
| Geddawy, A; Imamura, T; Iwasaki, H; Masada, M; Okamura, T; Shimosato, T; Shinozaki, K; Shintaku, H; Tawa, M; Yoshida, Y | 1 |
| Ma, CC; Ma, S | 1 |
| Jarjoura, D; Khayat, RN; Pleister, A; Porter, K; Sow, A; Varadharaj, S; Wannemacher, J; Zweier, JL | 1 |
| Kenney, WL; Stanhewicz, AE | 1 |
| Bailey, J; Channon, KM; Crabtree, MJ; Fischer, R; Kessler, BM; McCullagh, J; Ryan, BJ; Shaw, A; Wade-Martins, R | 1 |
| Hirata, K; Inoue, N; Kawashima, S; Masano, T; Nakajima, K; Nishimura, K; Sasaki, N; Satomi-Kobayashi, S; Shinohara, M; Sugiyama, D; Takaya, T; Takeda, M; Tawa, H; Toh, R; Yamashita, T; Yokoyama, M | 1 |
| Vásquez-Vivar, J | 1 |
| Förstermann, U | 1 |
| Ketonen, J; Mervaala, E; Pilvi, T | 1 |
| Channon, KM; Cunnington, C | 1 |
| Antoniades, C; Koutsogiannis, M; Papageorgiou, N; Siasos, G; Stefanadis, C; Tousoulis, D; Tsiamis, E | 1 |
| Kass, D; Kietadisorn, R; Lin, JY; Moens, AL | 1 |
| Förstermann, U; Sessa, WC | 1 |
| Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER | 1 |
| Channon, KM; McNeill, E | 1 |
| Hoang, HH; Meininger, CJ; Padgham, SV | 1 |
| Channon, KM | 1 |
| Kashiwagi, A; Masada, M; Okamura, T; Shinozaki, K | 1 |
| Kass, DA; Moens, AL | 2 |
| Ding, QF; Hattori, Y; Hayashi, T; Iguchi, A; Miyazaki-Akita, A; Nomura, T; Shiraishi, H | 1 |
| Fox, DA; Haruna, Y; Kashihara, N; Morita, Y; Satoh, M; Yada, T | 1 |
| Hirata, Y; Nagata, D | 1 |
| Ozkor, MA; Quyyumi, AA | 1 |
| Brandt, A; Braun-Dullaeus, RC; Heerwagen, C; Kasper, M; Schmeisser, A; Schober, K; Schwencke, C; Steinbronn, N; Strasser, RH; Tausche, AK; Wunderlich, C | 1 |
| Tiefenbacher, CP | 1 |
| Rabelink, TJ; Stroes, E; Verhaar, MC | 1 |
24 review(s) available for sapropterin and Cardiovascular Diseases
| Article | Year |
|---|---|
Tetrahydrobiopterin in energy metabolism and metabolic diseases.
Topics: Animals; Biopterins; Cardiovascular Diseases; Energy Metabolism; Humans; Metabolic Diseases; Mitochondria; Nitric Oxide Synthase | 2020 |
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Topics: Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Tetrahydrofolates | 2018 |
The regulation of vascular tetrahydrobiopterin bioavailability.
Topics: Administration, Oral; Animals; Biological Availability; Biopterins; Cardiovascular Diseases; Humans; Nitric Oxide; Nitric Oxide Synthase; Phenylalanine Hydroxylase; Phenylketonurias | 2013 |
Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.
Topics: Adipose Tissue; Arginine; Biological Transport; Biopterins; Cardiovascular Diseases; Cardiovascular System; Citrulline; Diet; Dietary Supplements; Humans; Nitric Oxide Synthase | 2014 |
Tetrahydrobiopterin regulation of eNOS redox function.
Topics: Animals; Biopterins; Cardiovascular Diseases; Humans; Nitric Oxide Synthase Type III; Oxidation-Reduction | 2014 |
Tetrahydrobiopterin in cardiovascular health and disease.
Topics: Atherosclerosis; Biopterins; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Humans; Inflammation; Nitric Oxide Synthase Type III; Oxidation-Reduction | 2014 |
Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies.
Topics: Animals; Ascorbic Acid; Biomarkers; Biopterins; Cardiovascular Diseases; Guinea Pigs; Humans; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrogen; Oxygen; Phosphorylation; Rats; Reactive Oxygen Species; Risk; Vasodilation | 2014 |
Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide.
Topics: Animals; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III | 2014 |
Role of folic acid in nitric oxide bioavailability and vascular endothelial function.
Topics: Antioxidants; Biological Availability; Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Randomized Controlled Trials as Topic; Vascular Diseases | 2017 |
Tetrahydrobiopterin, superoxide, and vascular dysfunction.
Topics: Biopterins; Cardiovascular Diseases; Humans; Superoxides; Vasodilation | 2009 |
Nitric oxide and oxidative stress in vascular disease.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase | 2010 |
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
Topics: Animals; Autonomic Nervous System; Biopterins; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Reperfusion Injury | 2010 |
Endothelial dysfunction: potential clinical implications.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Atherosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Nitric Oxide; Risk Factors | 2010 |
Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin.
Topics: Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Heart; Humans; Isoenzymes; Molecular Targeted Therapy; Myocardium; Nitric Oxide Synthase | 2011 |
Nitric oxide synthases: regulation and function.
Topics: Animals; Arginine; Biopterins; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Mice; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 2012 |
The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Topics: Animals; Biopterins; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Leukocytes; Models, Cardiovascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2012 |
L-arginine, tetrahydrobiopterin, nitric oxide and diabetes.
Topics: Arginine; Biomarkers; Biopterins; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tetrahydrofolate Dehydrogenase | 2013 |
Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
Topics: Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2012 |
Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Muscle Relaxation; Nitric Oxide Synthase; Oxidative Stress; Pteridines | 2003 |
Tetrahydrobiopterin and cardiovascular disease.
Topics: Animals; Atherosclerosis; Biological Availability; Biopterins; Blood Vessels; Cardiovascular Diseases; Heart; Humans; Nitric Oxide Synthase; Oxidative Stress | 2006 |
[Molecular mechanism of cardiovascular damage induced by aldosterone].
Topics: Aldosterone; Animals; Biopterins; Cardiovascular Diseases; Cells, Cultured; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphoprotein Phosphatases; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2007 |
Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease.
Topics: Animals; Biopterins; Cardiovascular Agents; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Folic Acid; Humans; Nitric Oxide Synthase | 2007 |
Tetrahydrobiopterin.
Topics: Biopterins; Cardiovascular Diseases; Endothelium; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase | 2008 |
Folates and cardiovascular disease.
Topics: Arteriosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NAD+); Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Oxidoreductases | 2002 |
1 trial(s) available for sapropterin and Cardiovascular Diseases
| Article | Year |
|---|---|
Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction.
Topics: Aged; Atorvastatin; Biomarkers; Biopterins; Brachial Artery; Cardiovascular Diseases; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Predictive Value of Tests; Pyrroles; Risk Assessment; Risk Factors; Ultrasonography; Vasodilation | 2009 |
12 other study(ies) available for sapropterin and Cardiovascular Diseases
| Article | Year |
|---|---|
CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Biopterins; Cardiovascular Diseases; Cell Cycle Proteins; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Reactive Oxygen Species | 2020 |
Does endothelial tetrahydrobiopterin control the endothelial NO synthase coupling state in arterial resistance arteries?
Topics: Animals; Arteries; Biopterins; Cardiovascular Diseases; Humans; Mice; Nitric Oxide Synthase Type III | 2017 |
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
Topics: Biomarkers; Biopterins; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Incidence; Isothiocyanates; Oxidative Stress; Prognosis; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sulfoxides | 2019 |
Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.
Topics: Amlodipine; Animals; Atorvastatin; Biopterins; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fructose; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Vasoconstriction; Vasodilation | 2014 |
Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction.
Topics: Adult; Biopterins; Cardiovascular Diseases; Continuous Positive Airway Pressure; Endothelium; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Sleep Apnea, Obstructive | 2015 |
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Topics: Animals; Biopterins; Cardiovascular Diseases; Endothelium; Energy Metabolism; GTP Cyclohydrolase; Humans; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Reactive Oxygen Species | 2017 |
Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.
Topics: Animals; Arginase; Biopterins; Body Weight; Caloric Restriction; Cardiovascular Diseases; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Superoxides; Time Factors; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2010 |
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine | 2012 |
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
Topics: Animals; Biopterins; Cardiovascular Diseases; Cattle; Cells, Cultured; Diabetes Complications; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Receptor alpha; Female; GTP Cyclohydrolase; Hyperglycemia; Nitric Oxide Synthase Type III; Nitrites; Postmenopause; Protein Kinase C; RNA, Small Interfering | 2007 |
Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.
Topics: Acetylcholine; Animals; Anticholesteremic Agents; Aorta, Thoracic; Arthritis, Experimental; Arthritis, Rheumatoid; Biopterins; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Inbred Lew; Superoxides; Vasodilation; Vasodilator Agents | 2007 |
The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium.
Topics: Animals; Biopterins; Cardiovascular Diseases; Catheterization; Caveolin 1; Dietary Supplements; Endothelium, Vascular; Enzyme Activation; Heart Function Tests; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Diseases; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phenotype | 2008 |
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2001 |