sapropterin has been researched along with Body Weight in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 17 (60.71) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alcalde, C; Aldámiz-Echevarría, L; Andrade, F; Blasco, J; Bueno, MA; Couce, ML; Dalmau, J; García, MC; Gil, D; González, D; González-Lamuño, D; Lage, S; Llarena, M; Ruiz, M; Ruiz, MA; Sánchez-Valverde, F; Vitoria, I | 1 |
| Shen, S; Tian, Y; Wang, B; Wang, C; Zhang, S | 1 |
| Alcalde, C; Aldámiz-Echevarría, L; Andrade, F; Blasco, J; Bueno, MA; Couce, ML; Dalmau, J; García, MC; Gil, D; González, D; González-Lamuño, D; Lage, S; Llarena, M; Peña-Quintana, L; Ruiz, M; Ruiz, MA; Sánchez-Valverde, F; Vitoria, I | 1 |
| Bai, F; Chang, P; Li, X; Lin, X; Wang, Q; Xu, H; Yang, M; Yu, J; Zhang, X; Zhang, Z; Zhao, F; Zhao, X | 1 |
| Adamsen, D; Beckers, J; Blau, N; Crabtree, M; Fuchs, H; Gailus-Durner, V; Homma, D; Horsch, M; Hrabě de Angelis, M; Ichinose, H; Klingenspor, M; Konrad, D; Korner, G; Ledermann, B; Rassi, A; Rathkolb, B; Rebuffat, A; Rozman, J; Scavelli, R; Scherer, T; Thöny, B; Wolf, E; Wolfrum, C | 1 |
| Clarke, L; Dorenbaum, A; Feillet, F; Foehr, E; Giovannini, M; Green, B; Harmatz, P; Lipson, M; Meli, C; Morris, AA; Mould, DR | 1 |
| Frauendienst-Egger, G; Scheible, D; Trefz, FK | 1 |
| Ketonen, J; Mervaala, E; Pilvi, T | 1 |
| Blau, N; Burki, K; Elzaouk, L; Ledermann, B; Leimbacher, W; Thony, B; Turri, M | 1 |
| Ballhausen, D; Blau, N; Fiege, B; Goriounov, D; Kierat, L; Leimbacher, W; Schircks, B; Thöny, B | 1 |
| Earl, J; McKenzie, KU; Pang, T; Schyvens, CG; Whitworth, JA; Zhang, Y | 1 |
| deBlois, D; Der Sarkissian, S; Duguay, D; Marchand, EL | 1 |
| Croatt, AJ; d'Uscio, LV; Katusic, ZS; Nath, KA; Peterson, TE; Pflueger, A; Smith, LA | 1 |
| Mayhan, WG; Sun, H | 1 |
| Al-Mulla, F; Al-Saleh, E; Bitar, MS; Dhaunsi, GS; Mustafa, S; Wahid, S | 1 |
| Akimoto, K; Gross, SS; Hattori, S; Hattori, Y; Kasai, K | 1 |
| Bessard, G; Caron, F; Lefebvre, B; Stanke-Labesque, F | 1 |
| Hosoi, M; Imanishi, M; Konishi, Y; Masada, M; Miura, K; Morikawa, T; Okada, N; Okumura, M; Shintaku, H; Yoshida, Y | 1 |
| Croft, KD; Earl, J; Hu, L; Kanjanapan, Y; Lee, SY; Lim, PS; McKenzie, KU; Miao, Y; Mori, TA; Whitworth, JA; Zhang, Y | 1 |
| Bauersachs, J; Brandt, M; Closs, E; Daiber, A; Ertl, G; Förstermann, U; Münzel, T; Oelze, M; Thum, T; Wenzel, P; Xu, J; Zou, MH | 1 |
| Alp, NJ; Channon, KM; Chen, AF; Du, YH; Guan, YY | 1 |
| Apelqvist, G; Bengtsson, F; Bergqvist, PB; Bugge, M; Wachter, H; Werner, ER | 1 |
| Iino, T; Sawada, H; Takikawa, S; Tsusué, M | 1 |
| Eda, S; Masada, M; Yoshida, YI | 1 |
| Cringle, SJ; Su, EN; Yu, DY; Yu, PK | 1 |
| Mayhan, WG; Patel, KP; Sun, H | 1 |
| Goldberg, A; McIntosh, MJ; Meredith, PA; Moore, MR | 1 |
| Combs, AB; Folkers, K; Lewandowski, EM | 1 |
1 trial(s) available for sapropterin and Body Weight
| Article | Year |
|---|---|
Pharmacokinetics of sapropterin in patients with phenylketonuria.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Biopterins; Body Weight; Child; Creatinine; Dose-Response Relationship, Drug; Europe; Female; Follow-Up Studies; Half-Life; Humans; Male; Metabolic Clearance Rate; Models, Biological; Phenylalanine; Phenylketonurias; United States; Young Adult | 2008 |
27 other study(ies) available for sapropterin and Body Weight
| Article | Year |
|---|---|
Tetrahydrobiopterin therapy vs phenylalanine-restricted diet: impact on growth in PKU.
Topics: Biopterins; Body Composition; Body Height; Body Mass Index; Body Weight; Diet; Follow-Up Studies; Humans; Phenylalanine; Phenylketonurias | 2013 |
Effects of simulated heat waves on ApoE-/- mice.
Topics: Animals; Atherosclerosis; Biomarkers; Biopterins; Body Temperature; Body Weight; Coronary Disease; Drug Evaluation, Preclinical; Endothelin-1; Extreme Heat; Infrared Rays; Male; Mice; Mice, Knockout; Nitric Oxide; Random Allocation; Superoxide Dismutase | 2014 |
6R-tetrahydrobiopterin treated PKU patients below 4 years of age: Physical outcomes, nutrition and genotype.
Topics: Biopterins; Body Height; Body Weight; Child, Preschool; Diet, Protein-Restricted; Female; Genotype; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Mutation; Nutritional Status; Phenylalanine; Phenylketonurias; Retrospective Studies; Spain | 2015 |
Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway in spontaneously hypertensive rats.
Topics: Animals; Biopterins; Blood Pressure; Body Weight; Diastole; Hypertension; Hypertrophy, Left Ventricular; Male; Organ Size; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Valine; Valsartan | 2015 |
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Topics: Adipose Tissue; Alleles; Animals; Biopterins; Body Fat Distribution; Body Weight; Cholesterol; Female; Genotype; Glucose; Heterozygote; Homozygote; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Obesity, Abdominal; Phenylalanine; Phosphorus-Oxygen Lyases; Transcriptome | 2016 |
Long-term follow-up of patients with phenylketonuria receiving tetrahydrobiopterin treatment.
Topics: Adolescent; Biomarkers; Biopterins; Body Weight; Child; Child, Preschool; Combined Modality Therapy; Diet, Protein-Restricted; Drug Dosage Calculations; Follow-Up Studies; Humans; Infant; Infant, Newborn; Phenylalanine; Phenylketonurias; Time Factors; Treatment Outcome | 2010 |
Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.
Topics: Animals; Arginase; Biopterins; Body Weight; Caloric Restriction; Cardiovascular Diseases; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Superoxides; Time Factors; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2010 |
Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin.
Topics: 5-Hydroxytryptophan; Animals; Biopterins; Body Weight; Cell Division; Dopamine; Dwarfism; Gene Deletion; Genetic Vectors; Genotype; Heterozygote; Homozygote; Insulin-Like Growth Factor I; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Phenotype; Phosphorus-Oxygen Lyases; Polymerase Chain Reaction; Thyroxine; Time Factors | 2003 |
Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration.
Topics: Administration, Oral; Adult; Biopterins; Body Weight; Dithioerythritol; Dose-Response Relationship, Drug; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Models, Biological; Oxidation-Reduction; Time Factors | 2004 |
Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Biopterins; Blood Pressure; Body Weight; Hypertension; Male; Rats; Rats, Sprague-Dawley | 2004 |
Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Apoptosis; Arginine; Biopterins; Blood Pressure; Body Weight; DNA Fragmentation; Drug Synergism; Enalapril; Endothelium, Vascular; In Situ Nick-End Labeling; Male; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Vasodilator Agents | 2004 |
The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta, Thoracic; Biopterins; Blood Pressure; Body Weight; Chromatography, High Pressure Liquid; Glomerular Filtration Rate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hyperbilirubinemia; In Vitro Techniques; Muscle, Smooth, Vascular; Rats; Rats, Gunn; Rats, Wistar; Superoxides; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption.
Topics: Alcohol Drinking; Animals; Arterioles; Biopterins; Body Weight; Central Nervous System Depressants; Cerebrovascular Circulation; Diet; Dose-Response Relationship, Drug; Ethanol; Female; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Sex Characteristics; Vasodilation; Vasodilator Agents | 2005 |
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2005 |
Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats.
Topics: Adiponectin; Angiotensin II; Animals; Biopterins; Blood Pressure; Body Weight; Cyclic N-Oxides; Gene Expression Regulation; Heart Rate; Intercellular Signaling Peptides and Proteins; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels | 2005 |
Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arachidonate 5-Lipoxygenase; Benzoquinones; Biopterins; Blood Pressure; Body Weight; Dinoprost; Endothelium, Vascular; Hypertension; Indoles; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Nitroarginine; Propionates; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Leukotriene; Vasoconstriction | 2006 |
Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.
Topics: Animals; Biopterins; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nitric Oxide; Proteinuria; Rats; Rats, Inbred OLETF; Rats, Long-Evans | 2006 |
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors | 2007 |
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
Topics: Animals; Atorvastatin; Biopterins; Body Weight; Cell Adhesion Molecules; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Male; Microfilament Proteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pyrroles; Rats; Rats, Wistar; Stem Cells; Tetrahydrofolate Dehydrogenase; Vasodilation | 2008 |
Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
Topics: Animals; Biopterins; Blood Pressure; Body Weight; Coronary Vessels; Desoxycorticosterone; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypertension; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mineralocorticoids; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Renin; Sodium Chloride; Tenascin; Vascular Resistance; Vasodilation | 2008 |
Brain biopterin metabolism in chronic experimental hepatic encephalopathy.
Topics: Animals; Biopterins; Body Weight; Brain Chemistry; Chronic Disease; Exploratory Behavior; GTP Cyclohydrolase; Hepatic Encephalopathy; Male; Motor Activity; Organ Size; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan | 1995 |
Discovery of a new tetrahydrobiopterin-synthesizing enzyme in the lemon mutant of the silkworm Bombyx mori.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Body Weight; Bombyx; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Molecular Weight; Mutation; Pterins; Serotonin | 1996 |
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.
Topics: Aging; Animals; Animals, Newborn; Biopterins; Body Weight; Brain; Growth; Kidney; Liver; Mice; Mice, Inbred ICR; Organ Size; Pteridines | 2000 |
Tetrahydrobiopterin reverses the impairment of acetylcholine-induced vasodilatation in diabetic ocular microvasculature.
Topics: Acetylcholine; Animals; Antioxidants; Biopterins; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Rats; Rats, Sprague-Dawley; Retinal Vessels; Vasodilation; Vasodilator Agents | 2001 |
Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption.
Topics: Alcoholism; Animals; Antioxidants; Biopterins; Blotting, Western; Body Weight; Cerebral Arteries; Endothelium, Vascular; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pia Mater; Rats; Rats, Sprague-Dawley; Stroke | 2001 |
Neurotoxic action of lead: effect on tetrahydrobiopterin metabolism in the rat.
Topics: Animals; Biopterins; Body Weight; Bone and Bones; Brain; Dihydropteridine Reductase; Lead; Lead Poisoning; Male; Neurotoxins; Pteridines; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
The toxicity of tetrahydrobiopterin: acute and subchronic studies in mice.
Topics: Administration, Oral; Animals; Biopterins; Body Weight; Female; Injections, Intraperitoneal; Kidney Tubular Necrosis, Acute; Lethal Dose 50; Male; Mice; Organ Size; Probenecid; Time Factors | 1986 |