Page last updated: 2024-08-21

sapropterin and Blood Pressure, High

sapropterin has been researched along with Blood Pressure, High in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (3.23)	18.2507
2000's	32 (51.61)	29.6817
2010's	26 (41.94)	24.3611
2020's	2 (3.23)	2.80

Authors

Authors	Studies
Castrejón-Téllez, V; Cervantes-Yañez, EZ; Del Valle-Mondragón, L; Flores-Chávez, P; Guarner-Lans, V; Martínez-Memije, R; Oidor-Chan, VH; Pastelín-Hernández, G; Pérez-Torres, I; Soto-Peredo, CA; Torres-Narváez, JC; Varela-López, E; Vargas-González, Á	1
Ding, Y; Ramprasath, T; Wu, Y; Zou, MH	1
Guan, X; Lu, C; Meng, Y; Shang, B; Zhang, Z; Zhao, Y	1
Carrizzo, A; Civitillo, F; Damato, A; Franco, E; Marino, M; Pompeo, F; Puca, A; Santini, L; Traficante, A; Trimarco, V; Vecchione, C	1
Deveaux, DD; Liao, P; Lyles, RH; Park, J; Quyyumi, AA; Sher, S	1
Cai, H; Li, Q; Youn, JY	1
Bai, F; Chang, P; Li, X; Lin, X; Wang, Q; Xu, H; Yang, M; Yu, J; Zhang, X; Zhang, Z; Zhao, F; Zhao, X	1
Chen, L; Ding, ML; Duan, SZ; He, W; Li, J; Tao, J; Wu, F; Xia, WH; Xie, WL; Zhang, XY	1
Harrison, DG; Loperena, R	1
Bai, YP; Ren, Z; Tan, Z; Tang, H; Tang, YB; Xiao, S; Yang, Z; Zeng, H	1
Brook, RD; Cardounel, AJ; Chen, LC; Devlin, R; Hwang, JS; Rajagopalan, S; Sun, Q; Ying, Z; Yue, P; Zweier, JL	1
Chul Choi, H; Song, P; Wang, S; Wu, Y; Xu, J; Zhang, J; Zou, MH	1
Song, P; Wang, S; Wu, Y; Xu, J; Zou, MH	1
Han, JS; Jung, SH; Kim, B; Kim, HJ; Kim, J; Lee, CK; Lee, HM; Park, HJ; Park, PJ; Park, TK; Park, YS; Won, KJ	1
Deutz, NE; Engelen, MP; Luiking, YC	1
Daneshtalab, N; Smeda, JS	1
Bernstein, KE; Boulden, BM; Dikalov, S; Dudley, SC; Fan, TH; Fredd, S; Harrison, DG; Jiao, Z; Liu, H; Lovelock, JD; Silberman, GA; Widder, J; Wolska, BM; Xiao, HD	1
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M; Tsutsui, M	1
Ding, H; Triggle, CR	1
Channon, KM; Chen, AF; Chen, DD; Su, DF; Xie, HH; Zhou, S	1
d'Uscio, LV; Kang, KT; Katusic, ZS; Pollock, JS; Spradley, FT; Sullivan, JC	1
Liu, MF; Liu, SL; Zhu, BL	1
Lin, JY; Moens, AL	1
Blau, N; Thöny, B; Werner, ER	1
Cai, H; Chalupsky, K; Chen, P; Galis, Z; Gao, L; Nguyen, A; Siu, KL; Weintraub, NL	1
Chappell, MC; Chen, AF; Gallagher, PE; Lindsey, SH; Varagic, J; Yamaleyeva, LM; Zhang, LL	1
Blair, J; Cai, H; Harrison, DG; Laude, KM; McCann, LA; Oak, JH; Wang, T; Youn, JY	1
Cervantes-Pérez, LG; Del Valle-Mondragón, L; Escalante, B; Ibarra-Lara, Mde L; Pastelín, G; Pérez-Severiano, F; Sánchez-Mendoza, MA; Vargas-Robles, H	1
Alkaitis, MS; Crabtree, MJ	1
Carnicer, R; Casadei, B; Crabtree, MJ; Kass, DA; Sivakumaran, V	1
Balestra, C; Feray, A; Goanvec, C; Guerrero, F; Mansourati, J; Theunissen, S; Thioub, S	1
Chonchol, M; Gates, PE; Geolfos, CJ; Jablonski, KL; McQueen, MB; Racine, ML; Seals, DR	1
Hiroi, T; Ishibashi, M; Ishii, M; Kiuchi, Y; Kumagai, S; Kurihara, T; Shimizu, S; Wajima, T	1
Mitchell, BM; Webb, RC	1
Félétou, M; Levens, N; Vanhoutte, PM; Yang, D; Zhang, JN	2
Dikalov, S; Fukai, T; Harrison, DG; Holland, SM; Landmesser, U; McCann, L; Mitch, WE; Price, SR	1
Benchetrit, S; Bernheim, J; Podjarny, E; Pomeranz, A; Rashid, G; Rathaus, M; Shapira, J	1
Chen, AF; Fink, GD; Hesslinger, C; Kapatos, G; Kovesdi, I; Lookingland, KJ; Yang, XQ; Zheng, JS	1
Alp, NJ; Channon, KM	1
Dorrance, AM; Ergul, A; Mitchell, BM; Webb, RC	1
Elmarakby, AA; Kemp, BE; Pollock, DM; Pollock, JS; Sasser, JM; Sullivan, JC	1
Earl, J; McKenzie, KU; Pang, T; Schyvens, CG; Whitworth, JA; Zhang, Y	1
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y	1
Hirata, Y	1
Bernheim, J; Green, J; Hasdan, G; Korzets, Z; Podjarny, E; Rashid, G	1
Fortepiani, LA; Reckelhoff, JF	1
Madeddu, P	1
Hashikabe, Y; Hattori, Y; Kase, H; Nakanishi, N; Uchida, K	1
Bessard, G; Caron, F; Lefebvre, B; Stanke-Labesque, F	1
Clempus, RE; Dikalov, SI; Griendling, KK; Guzik, TJ; Harrison, DG; Jones, DP; Mueller, CF; Schmidt, HH; Widder, JD	1
Croft, KD; Earl, J; Hu, L; Kanjanapan, Y; Lee, SY; Lim, PS; McKenzie, KU; Miao, Y; Mori, TA; Whitworth, JA; Zhang, Y	1
Dong, YF; Ichijo, H; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Ogawa, H; Shintaku, H; Tokutomi, Y; Yamamoto, E; Yamashita, T	1
Alp, NJ; Channon, KM; Chen, AF; Du, YH; Guan, YY	1
Daiber, A; Jansen, T; Münzel, T; Schulz, E; Wenzel, P	1
Cheema, F; Harrison, D; Hooper, C; Jones, DP; Kolm, P; Niessner, C; Porkert, M; Quyyumi, AA; Reddy, U; Sher, S; Taylor, WR	1
Ozkor, MA; Quyyumi, AA	1
Alp, NJ; Bedja, D; Biswal, S; Chakir, K; Champion, HC; Channon, KM; Cormaci, G; Gabrielson, K; Halushka, MK; Kass, DA; Ketner, EA; Majmudar, M; Mitchell, JB; Moens, AL; Paolocci, N; Takimoto, E; Tocchetti, CG; Wolin, MS	1
Ashwal, S; Pearce, WJ; Tone, B	1
Cosentino, F; d'Uscio, LV; Lüscher, TF; Malinski, T; Moreau, P; Patton, S; Werner, ER; Werner-Felmayer, G	1
Cheng, TH; Hong, HJ; Hsiao, G; Yen, MH	1
Chayama, K; Fukuda, Y; Higashi, Y; Matsuura, H; Nakagawa, K; Oshima, T; Sasaki, S	1

Reviews

14 review(s) available for sapropterin and Blood Pressure, High

Article	Year
Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension. Antioxidants & redox signaling, 2021, 03-20, Volume: 34, Issue:9 Topics: Biopterins; GTP Cyclohydrolase; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction	2021
Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension. Journal of hypertension, 2015, Volume: 33, Issue:6 Topics: Antihypertensive Agents; Biopterins; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Reactive Oxygen Species; Superoxides	2015
Oxidative Stress and Hypertensive Diseases. The Medical clinics of North America, 2017, Volume: 101, Issue:1 Topics: Antioxidants; Biopterins; Blood Vessels; Central Nervous System; Humans; Hypertension; Inflammation; Kidney; Mitochondria; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; Xanthine Oxidase	2017
Regulation of nitric oxide production in health and disease. Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:1 Topics: Animals; Arginase; Arginine; Ascorbic Acid; Biopterins; Citrulline; Diet; Dietary Fats; Endothelium; Humans; Hypertension; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Sepsis	2010
Endothelial dysfunction in diabetes: multiple targets for treatment. Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:6 Topics: Animals; Biological Factors; Biopterins; Blood Glucose; Calcium; Cell Communication; Connexins; Diabetes Mellitus; Diabetic Angiopathies; Dyslipidemias; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Nitric Oxide Synthase Type III; Oxidative Stress; Transient Receptor Potential Channels	2010
Tetrahydrobiopterin: biochemistry and pathophysiology. The Biochemical journal, 2011, Sep-15, Volume: 438, Issue:3 Topics: Animals; Biopterins; Humans; Hypertension; Nitric Oxide Synthase; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2011
Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling. Current heart failure reports, 2012, Volume: 9, Issue:3 Topics: Animals; Biopterins; Coenzymes; Coronary Circulation; Endothelium, Vascular; Humans; Hypertension; Mice; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Superoxides	2012
Nitric oxide synthases in heart failure. Antioxidants & redox signaling, 2013, Mar-20, Volume: 18, Issue:9 Topics: Animals; Arginase; Autocrine Communication; Biopterins; Calcium Signaling; Cyclic GMP; Diabetes Mellitus; Disease Progression; Enzyme Activation; Enzyme Induction; Heart Diseases; Heart Failure; Humans; Hypertension; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Paracrine Communication; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Signal Transduction; Superoxides	2013
Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. Biological research for nursing, 2002, Volume: 4, Issue:1 Topics: Antioxidants; Biopterins; Cushing Syndrome; Endothelium; Glucocorticoids; Humans; Hypertension; Iatrogenic Disease; Nitric Oxide Synthase; Vasodilation	2002
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3 Topics: Animals; Biological Availability; Biopterins; Coenzymes; Diabetes Mellitus; Enzyme Induction; GTP Cyclohydrolase; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Mutant Strains; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pterins; Rabbits; Rats; Rats, Inbred Strains; Superoxides; Vascular Diseases	2004
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3 Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors	2004
[NO and hypertension]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arginine; Arteriosclerosis; Biopterins; C-Reactive Protein; Endothelium, Vascular; Humans; Hypertension; Mutation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perindopril; Reactive Oxygen Species; Vasodilation	2004
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxidants & redox signaling, 2008, Volume: 10, Issue:6 Topics: Animals; Biopterins; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Guanylate Cyclase; Humans; Hypertension; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase	2008
Tetrahydrobiopterin. Current hypertension reports, 2008, Volume: 10, Issue:1 Topics: Biopterins; Cardiovascular Diseases; Endothelium; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase	2008

Trials

2 trial(s) available for sapropterin and Blood Pressure, High

Article	Year
Tetrahydrobiopterin lowers muscle sympathetic nerve activity and improves augmentation index in patients with chronic kidney disease. American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Feb-01, Volume: 308, Issue:3 Topics: Biopterins; Blood Pressure; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Muscles; Nitric Oxide; Nitric Oxide Synthase; Pulse Wave Analysis; Renal Insufficiency, Chronic; Risk Factors; Sympathetic Nervous System; Vascular Stiffness	2015
Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. Journal of the American College of Cardiology, 2013, Jan-22, Volume: 61, Issue:3 Topics: Aged; Biological Availability; Biopterins; Blood Pressure; Brachial Artery; Cross-Over Studies; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Microcirculation; Middle Aged; Oxidative Stress; Regional Blood Flow; Sodium, Dietary; Vascular Resistance	2013

Article

Year

Tetrahydrobiopterin lowers muscle sympathetic nerve activity and improves augmentation index in patients with chronic kidney disease.

American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Feb-01, Volume: 308, Issue:3

Topics: Biopterins; Blood Pressure; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Muscles; Nitric Oxide; Nitric Oxide Synthase; Pulse Wave Analysis; Renal Insufficiency, Chronic; Risk Factors; Sympathetic Nervous System; Vascular Stiffness

2015

Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure.

Journal of the American College of Cardiology, 2013, Jan-22, Volume: 61, Issue:3

Topics: Aged; Biological Availability; Biopterins; Blood Pressure; Brachial Artery; Cross-Over Studies; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Microcirculation; Middle Aged; Oxidative Stress; Regional Blood Flow; Sodium, Dietary; Vascular Resistance

2013

Other Studies

46 other study(ies) available for sapropterin and Blood Pressure, High

Article	Year
The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats. International journal of environmental research and public health, 2019, 09-25, Volume: 16, Issue:19 Topics: Animals; Biomarkers; Biopterins; Blood Pressure; Capsaicin; Drug Evaluation, Preclinical; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Resistance	2019
Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway. BMC pharmacology & toxicology, 2020, 12-02, Volume: 21, Issue:1 Topics: Animals; Biopterins; Blood Pressure; Diastole; Drug Therapy, Combination; Guanosine Monophosphate; Hypertension; Male; Nebivolol; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction	2020
Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 62, Issue:2 Topics: Acetylcholine; Biopterins; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; NF-E2-Related Factor 2; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Resveratrol; Stilbenes; Superoxide Dismutase; Vasodilation	2013
Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway in spontaneously hypertensive rats. Biochemical and biophysical research communications, 2015, Aug-07, Volume: 463, Issue:4 Topics: Animals; Biopterins; Blood Pressure; Body Weight; Diastole; Hypertension; Hypertrophy, Left Ventricular; Male; Organ Size; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Valine; Valsartan	2015
Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 67, Issue:2 Topics: Animals; Biopterins; Blood Pressure; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Vascular; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Mice; Mice, Nude; Nitric Oxide Synthase; Oxidative Stress; Retrospective Studies; Vasodilation	2016
Shear stress-mediated upregulation of GTP cyclohydrolase/tetrahydrobiopterin pathway ameliorates hypertension-related decline in reendothelialization capacity of endothelial progenitor cells. Journal of hypertension, 2017, Volume: 35, Issue:4 Topics: Animals; Biopterins; Cells, Cultured; Cyclic GMP; Down-Regulation; Endothelial Progenitor Cells; Gene Knockdown Techniques; GTP Cyclohydrolase; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Male; Metabolic Networks and Pathways; Mice; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Stress, Mechanical; Thrombospondin 1; Up-Regulation	2017
Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:10 Topics: Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Blood Pressure; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Infusion Pumps, Implantable; Inhalation Exposure; Male; Myosin Light Chains; NADPH Oxidases; Nitric Oxide Synthase; Particle Size; Particulate Matter; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Time Factors; Vasoconstriction	2008
Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:3 Topics: Animals; Aorta; Biopterins; Blood Pressure; Cattle; Endothelial Cells; Enzyme Inhibitors; GTP Cyclohydrolase; Hypertension; Hypoxanthines; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Culture Techniques; Oxidative Stress; Pterins; RNA, Small Interfering; Serotonin; Superoxides; Vasodilation	2008
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation	2009
Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. Proteomics, 2009, Volume: 9, Issue:21 Topics: Amino Acid Sequence; Animals; Aorta; Biomarkers; Biopterins; Blood Pressure; Dihydropteridine Reductase; Gene Expression Regulation, Enzymologic; Hypertension; Male; Molecular Sequence Data; Muscle, Smooth; Proteomics; Rats; Rats, Inbred SHR; Rats, Inbred WKY	2009
Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke. Cardiovascular research, 2010, Apr-01, Volume: 86, Issue:1 Topics: Animals; Arginine; Biopterins; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Enzyme Inhibitors; Homeostasis; Hypertension; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Stroke; Vasodilation	2010
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation, 2010, Feb-02, Volume: 121, Issue:4 Topics: Animals; Biopterins; Calcium-Binding Proteins; Desoxycorticosterone; Disease Models, Animal; Heart Failure, Diastolic; Hypertension; Male; Mice; Mice, Inbred C57BL; Myocardium; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Peptidyl-Dipeptidase A; Superoxides; Ventricular Dysfunction, Left	2010
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. European journal of pharmacology, 2010, Apr-10, Volume: 631, Issue:1-3 Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biopterins; Dietary Supplements; Endothelium, Vascular; Hemodynamics; Hypertension; In Vitro Techniques; Infusions, Intravenous; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2010
GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Biopterins; Cell Adhesion; Desoxycorticosterone; GTP Cyclohydrolase; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroarginine; Oxidative Stress; Polyethylene Glycols; Stem Cells; Superoxide Dismutase; Superoxides; Thrombospondin 1	2010
Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3 Topics: Angiotensin II; Animals; Antihypertensive Agents; Biopterins; Cyclic GMP; GTP Cyclohydrolase; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reserpine; Signal Transduction	2011
[Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2009, Volume: 25, Issue:3 Topics: Animals; Arteries; Arteriolosclerosis; Biomechanical Phenomena; Biopterins; Hypertension; Male; Nitric Oxide Synthase; Random Allocation; Rats; Rats, Inbred SHR	2009
Tetrahydrobiopterin and hypertension: more than an emigrating story. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3 Topics: Angiotensin II; Animals; Antihypertensive Agents; Biopterins; Drug Therapy, Combination; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Reserpine; Signal Transduction	2011
Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:1 Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Biopterins; Blood Pressure; Disease Models, Animal; Folic Acid; Genetic Therapy; GTP Cyclohydrolase; Hypertension; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase Type III; Tetrahydrofolate Dehydrogenase; Vasoconstrictor Agents; Vitamin B Complex	2012
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Oxidative Stress; Rats; Rats, Inbred Lew; Renin; RNA, Messenger; Sodium Chloride, Dietary	2012
Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. American journal of physiology. Heart and circulatory physiology, 2012, Jun-01, Volume: 302, Issue:11 Topics: Acetophenones; Alcohol Oxidoreductases; Animals; Aorta; Biopterins; Blood Pressure; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nitric Oxide; Nitric Oxide Synthase Type III; Oxygen; Pterins	2012
Endothelial nitric oxide synthase impairment is restored by clofibrate treatment in an animal model of hypertension. European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3 Topics: Animals; Biopterins; Clofibrate; Disease Models, Animal; GTP Cyclohydrolase; Hypertension; Hypolipidemic Agents; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; PPAR alpha; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides	2012
Effect of tetrahydrobiopterin and exercise training on endothelium-dependent vasorelaxation in SHR. Journal of physiology and biochemistry, 2013, Volume: 69, Issue:2 Topics: Animals; Biopterins; Blood Pressure; Endothelium, Vascular; Femoral Artery; Hypertension; In Vitro Techniques; Male; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation	2013
Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. International journal of molecular medicine, 2013, Volume: 31, Issue:3 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Arterial Pressure; Biopterins; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Male; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger	2013
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:1 Topics: Acetylcholine; Animals; Aorta; Biopterins; Culture Techniques; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Nitric Oxide Synthase; Nitroarginine; Pteridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Reducing Agents; Vasoconstriction; Vasodilation	2003
A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:1 Topics: Acetylcholine; Animals; Aorta; Biological Assay; Biopterins; Cyclooxygenase 1; Diffusion; Endothelium, Vascular; Hypertension; Isoenzymes; Male; Membrane Proteins; Muscle, Smooth, Vascular; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Receptors, Thromboxane; Vasoconstriction; Vasoconstrictor Agents	2003
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. The Journal of clinical investigation, 2003, Volume: 111, Issue:8 Topics: Animals; Biopterins; Desoxycorticosterone; Endothelium, Vascular; Hydrogen Peroxide; Hypertension; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Vasodilation	2003
Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. Nephron. Physiology, 2003, Volume: 94, Issue:1 Topics: Animals; Arginine; Biopterins; Blood Pressure; Creatinine; Hypertension; Kidney; Male; Mesenteric Arteries; Nephrectomy; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Insufficiency	2003
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation, 2003, Sep-09, Volume: 108, Issue:10 Topics: Acetophenones; Animals; Antioxidants; Atrasentan; Biopterins; Carotid Arteries; Cyclic N-Oxides; Desoxycorticosterone; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Gene Transfer Techniques; Genetic Therapy; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Male; Nitric Oxide; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Spin Labels; Superoxides; Vasodilation	2003
Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:1 Topics: Animals; Antioxidants; Biopterins; Endothelium, Vascular; Hypertension; Male; Nitric Oxide Synthase; Pterins; Rats; Rats, Sprague-Dawley; Vasodilation	2004
Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Biopterins; Codon; Cyclic GMP; Desoxycorticosterone; Hypertension; Male; Mesenteric Arteries; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Phenylephrine; Phosphorylation; Phosphoserine; Polyethylene Glycols; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride, Dietary; Superoxide Dismutase	2004
Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. Clinical and experimental hypertension (New York, N.Y. : 1993), 2004, Volume: 26, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Biopterins; Blood Pressure; Body Weight; Hypertension; Male; Rats; Rats, Sprague-Dawley	2004
Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:9 Topics: Animals; Antihypertensive Agents; Antioxidants; Arginine; Biopterins; Blood Pressure; Diltiazem; Glomerular Mesangium; Hypertension; Kidney Failure, Chronic; Male; Models, Animal; Nephrectomy; Nitric Oxide; Oxidative Stress; Proteinuria; Rats; Rats, Wistar; Vasodilator Agents	2004
Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis. American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 288, Issue:3 Topics: Animals; Biopterins; Blood Pressure; Drug Administration Schedule; Hypertension; Male; Nitric Oxide Donors; Orchiectomy; Rats; Rats, Inbred SHR; Sodium Nitrite; Testosterone	2005
Correction of endothelial dysfunction by tetrahydrobiopterin: new hope for the treatment of arterial hypertension? Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Angiotensin II; Animals; Antioxidants; Biopterins; Cardiomegaly; Endothelium, Vascular; Hypertension; Immunohistochemistry; Male; Myocardium; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Tyrosine; Up-Regulation	2005
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation	2005
Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. Journal of hypertension, 2006, Volume: 24, Issue:1 Topics: Acetylcholine; Animals; Aorta, Thoracic; Arachidonate 5-Lipoxygenase; Benzoquinones; Biopterins; Blood Pressure; Body Weight; Dinoprost; Endothelium, Vascular; Hypertension; Indoles; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Nitroarginine; Propionates; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Leukotriene; Vasoconstriction	2006
Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:4 Topics: Angiotensin II; Animals; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biopterins; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Glutathione Disulfide; Hypertension; Isoenzymes; Male; Mice; Mice, Inbred Strains; Mice, Knockout; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Superoxides; Vasodilation	2007
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat. American journal of hypertension, 2007, Volume: 20, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors	2007
Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12 Topics: Acetophenones; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Biopterins; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Endothelium, Vascular; Heart Failure, Diastolic; Hydralazine; Hypertension; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Signal Transduction; Sodium Chloride, Dietary; Superoxides; Tetrazoles; Time Factors; Valine; Valsartan; Vasodilation	2007
Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation, 2008, Feb-26, Volume: 117, Issue:8 Topics: Animals; Biopterins; Blood Pressure; Body Weight; Coronary Vessels; Desoxycorticosterone; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypertension; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mineralocorticoids; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Renin; Sodium Chloride; Tenascin; Vascular Resistance; Vasodilation	2008
Tetrahydrobiopterin: a novel antihypertensive therapy. Journal of human hypertension, 2008, Volume: 22, Issue:6 Topics: Adult; Aged; Biopterins; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Vasodilation	2008
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation, 2008, May-20, Volume: 117, Issue:20 Topics: Animals; Biopterins; Cardiomegaly; Cyclic N-Oxides; Disease Models, Animal; Fibrosis; Gene Expression Profiling; GTP Cyclohydrolase; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Nitric Oxide Synthase Type III; Spin Labels	2008
Maturation alters cerebral NOS kinetics in the spontaneously hypertensive rat. The American journal of physiology, 1997, Volume: 273, Issue:4 Topics: Aging; Animals; Animals, Newborn; Biopterins; Brain; Calmodulin; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hypertension; Kinetics; Nitric Oxide Synthase; Rats; Rats, Inbred SHR	1997
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. The Journal of clinical investigation, 1998, Apr-01, Volume: 101, Issue:7 Topics: Animals; Aorta; Biopterins; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Vasomotor System	1998
Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5 Topics: Acetylcholine; Animals; Antioxidants; Aorta; Biopterins; Blood Pressure; Culture Techniques; Dietary Supplements; Endothelium, Vascular; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Vasodilation	2001
Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. American journal of hypertension, 2002, Volume: 15, Issue:4 Pt 1 Topics: Acetylcholine; Adult; Biopterins; Drug Synergism; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Regional Blood Flow	2002