sapropterin has been researched along with Atherogenesis in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (46.15) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, YT; Jian, YP; Li, SX; Li, Y; Li, YQ; Liu, Z; Ma, J; Ning, DS; Ou, JS; Ou, ZJ; Peng, YM; Zhang, YX | 1 |
| Al Haj Zen, A; Channon, KM; Chuaiphichai, S; Crabtree, MJ; Douglas, G; Hale, AB; McNeill, E; Patel, J; Rashbrook, VS; Trelfa, L | 1 |
| Daiber, A; Münzel, T | 1 |
| Cao, G; Chen, W; Dong, F; Li, J; Liu, S; Sun, Y; Xu, J; Zhang, C; Zhang, W | 1 |
| Bendall, JK; Channon, KM; Crabtree, MJ; Douglas, G; McNeill, E | 1 |
| Shen, S; Tian, Y; Wang, B; Wang, C; Zhang, S | 1 |
| Chen, W; Harrison, DG; Hofmeister, LH; Lee, SH; Montaniel, KR; Norlander, AE; Sung, HJ | 1 |
| Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kitabata, H; Kuroi, A; Mochizuki, S; Muragaki, Y; Takarada, S; Tanimoto, T; Tsujioka, H; Yoshida, K | 1 |
| Akhtar, AM; Ali, ZA; Alp, NJ; Bendall, JK; Bursill, CA; Channon, KM; Douglas, G; Greaves, DR; McNeill, E; Papaspyridonos, M; Tatham, AL | 1 |
| Antoniades, C; Antonopoulos, AS; Bakogiannis, C; Demosthenous, M; Psarros, C; Stefanadis, C; Tousoulis, D | 1 |
| Alp, NJ; Channon, KM; Cheng, A; Crabtree, MJ; Douglas, G; Hale, AB; Khoo, J; McNeill, E; O'Neill, CA; Schmidt, TS | 1 |
| Antoniades, C; Koutsogiannis, M; Papageorgiou, N; Siasos, G; Stefanadis, C; Tousoulis, D; Tsiamis, E | 1 |
| Gielis, JF; Lin, JY; Moens, AL; Schmidt, HH; Van Schil, PE; Wingler, K | 1 |
| Chen, W; Harrison, DG; Jo, H; Li, L; Rezvan, A | 1 |
| Antoniades, C; Antonopoulos, A; Bakogiannis, C; Bendall, J; Cerrato, R; Channon, KM; Cunnington, C; Demosthenous, M; Hale, A; Karpe, F; Leeson, P; Margaritis, M; Marinou, K; Neville, M; Stefanadis, C; Tousoulis, D; Toutouza, M; Vlachopoulos, C | 1 |
| Choi, YH; Noh, JS; Song, YO | 1 |
| Brooks, RM; Castaneda, LE; Chu, Y; Heistad, DD; Miller, JD; Serrano, KM | 1 |
| d'Uscio, LV; Katusic, ZS | 1 |
| Corti, R; Flammer, A; Hermann, F; Lüscher, TF; Noll, G; Spieker, LE; Sudano, I | 1 |
| Antoniades, C; Cai, S; Channon, KM; de Bono, J; Lee, J; Leeson, P; Neubauer, S; Pillai, R; Ratnatunga, C; Refsum, H; Shirodaria, C; Warrick, N | 1 |
| Kass, DA; Moens, AL | 1 |
| Hattori, S; Hattori, Y; Kasai, K; Nakanishi, N; Satoh, H; Wang, X | 1 |
| Alp, NJ; Channon, KM; Fukatsu, A; Goto, M; Hayashi, T; Hirata, K; Inoue, N; Kawashima, S; Sasaki, N; Shinohara, M; Takaya, T; Yada, T; Yamashita, T; Yokoyama, M | 1 |
| Alp, NJ; Schmidt, TS | 1 |
| Anderson, TJ; Curtis, MJ; Goodhart, DM; Kanani, RS; Sun, Y; Sun, YH; Worthley, MI | 1 |
| Duncan, ER; Kahn, M; Kearney, MT; Wheatcroft, SB | 1 |
8 review(s) available for sapropterin and Atherogenesis
| Article | Year |
|---|---|
Tetrahydrobiopterin in cardiovascular health and disease.
Topics: Atherosclerosis; Biopterins; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Humans; Inflammation; Nitric Oxide Synthase Type III; Oxidation-Reduction | 2014 |
Novel therapeutic strategies targeting vascular redox in human atherosclerosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Antioxidants; Atherosclerosis; Biopterins; Endothelium, Vascular; Folic Acid; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Thiazolidinediones | 2009 |
Endothelial dysfunction: potential clinical implications.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Atherosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Nitric Oxide; Risk Factors | 2010 |
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders.
Topics: Arginine; Atherosclerosis; Biopterins; Blood Pressure; Cardiac Surgical Procedures; Cell Adhesion; Endothelium, Vascular; Folic Acid; Humans; Hypertension, Pulmonary; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Reactive Oxygen Species; Vasodilation; Ventricular Remodeling | 2011 |
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Atherosclerosis; Biopterins; Cacao; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dyslipidemias; Endothelin-1; Endothelins; Endothelium, Vascular; Flavonoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, HDL; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species | 2006 |
Tetrahydrobiopterin and cardiovascular disease.
Topics: Animals; Atherosclerosis; Biological Availability; Biopterins; Blood Vessels; Cardiovascular Diseases; Heart; Humans; Nitric Oxide Synthase; Oxidative Stress | 2006 |
Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.
Topics: Animals; Ascorbic Acid; Atherosclerosis; Biopterins; Disease Progression; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Reactive Oxygen Species; Vitamins | 2007 |
Insulin resistance and endothelial cell dysfunction: studies in mammalian models.
Topics: Animals; Atherosclerosis; Biological Availability; Biopterins; Calcium; Endothelial Cells; Humans; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Reactive Oxygen Species; Vascular Diseases | 2008 |
3 trial(s) available for sapropterin and Atherogenesis
| Article | Year |
|---|---|
Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Topics: Adult; Aged; Atherosclerosis; Biopterins; Double-Blind Method; Endothelium, Vascular; Enzyme Induction; Female; GTP Cyclohydrolase; Haplotypes; Humans; Inflammation Mediators; Male; Middle Aged | 2011 |
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Topics: Acetylcholine; Antioxidants; Atherosclerosis; Biological Availability; Biopterins; Bradykinin; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Superoxides; Tetrahydrofolates | 2006 |
Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries.
Topics: Acetylcholine; Aged; Angioplasty, Balloon, Coronary; Atherosclerosis; Biopterins; Combined Modality Therapy; Coronary Vessels; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Regional Blood Flow; Stents; Treatment Outcome; Vasodilator Agents | 2007 |
15 other study(ies) available for sapropterin and Atherogenesis
| Article | Year |
|---|---|
Apolipoprotein A-I mimetic peptide inhibits atherosclerosis by increasing tetrahydrobiopterin via regulation of GTP-cyclohydrolase 1 and reducing uncoupled endothelial nitric oxide synthase activity.
Topics: Animals; Apolipoprotein A-I; Atherosclerosis; Biopterins; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Guanosine Triphosphate; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Superoxides | 2021 |
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Biopterins; Blood Pressure; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Foam Cells; GTP Cyclohydrolase; Macrophages; Male; Mice, Knockout, ApoE; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Plaque, Atherosclerotic; Reactive Oxygen Species; Vascular Cell Adhesion Molecule-1; Vasoconstriction; Vasodilation | 2018 |
Role of endothelial and macrophage tetrahydrobiopterin in development and progression of atherosclerosis: BH4 puzzle solved?
Topics: Atherosclerosis; Biopterins; Endothelial Cells; Humans; Macrophages | 2018 |
Nicotine induces endothelial dysfunction and promotes atherosclerosis via GTPCH1.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biopterins; ELAV-Like Protein 1; Endothelial Cells; Gene Expression Regulation; GTP Cyclohydrolase; Human Umbilical Vein Endothelial Cells; Humans; Mice; Nicotine; Nitric Oxide; Pterins; Reactive Oxygen Species; Risk Factors; RNA, Messenger; Smoking | 2018 |
Effects of simulated heat waves on ApoE-/- mice.
Topics: Animals; Atherosclerosis; Biomarkers; Biopterins; Body Temperature; Body Weight; Coronary Disease; Drug Evaluation, Preclinical; Endothelin-1; Extreme Heat; Infrared Rays; Male; Mice; Mice, Knockout; Nitric Oxide; Random Allocation; Superoxide Dismutase | 2014 |
Phage-display-guided nanocarrier targeting to atheroprone vasculature.
Topics: Amino Acid Sequence; Animals; Apolipoproteins E; Atherosclerosis; Biopterins; Carotid Arteries; Disease Susceptibility; Drug Carriers; Male; Mice; Molecular Sequence Data; Nanomedicine; Nanostructures; Oligopeptides; Peptide Library | 2015 |
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Atherosclerosis; Biopterins; Blood Pressure; Drug Therapy, Combination; Endothelium, Vascular; Fumarates; Heart Rate; HSP90 Heat-Shock Proteins; Hyperlipidemias; Inflammation Mediators; Lipids; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rabbits; Renin; Tetrazoles; Tyrosine; Valine; Valsartan; Vasodilation; Vasodilator Agents | 2008 |
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biopterins; Blood Vessels; Carotid Arteries; Chemokine CCL2; Chemotaxis; Endothelium, Vascular; Female; GTP Cyclohydrolase; Humans; Hyperplasia; Macrophages; Male; Mice; Mice, Knockout; Mice, Transgenic; Nitric Oxide Synthase Type III; Receptors, CCR2; Superoxides; Tunica Intima; Up-Regulation; Vasculitis; Venae Cavae; Wounds and Injuries | 2008 |
Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
Topics: Administration, Oral; Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biopterins; Chemotaxis, Leukocyte; Disease Progression; Drug Administration Schedule; Drug Evaluation, Preclinical; Endothelium, Vascular; Hemodynamics; Lipids; Male; Mice; Mice, Knockout; RNA, Messenger; Tissue Distribution; Vascular Cell Adhesion Molecule-1 | 2010 |
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biopterins; Carotid Artery, Common; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Inflammation; Inflammation Mediators; Ligation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Regional Blood Flow; Superoxides; T-Lymphocytes; Vasodilation; Vasodilator Agents | 2011 |
Beneficial effects of the active principle component of Korean cabbage kimchi via increasing nitric oxide production and suppressing inflammation in the aorta of apoE knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aortitis; Apolipoproteins E; Arginine; Atherosclerosis; Biopterins; Cell Adhesion Molecules; Diet, Atherogenic; Disease Models, Animal; Down-Regulation; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phenyl Ethers; Propionates; Random Allocation; Reactive Oxygen Species; Up-Regulation | 2013 |
Vascular function during prolonged progression and regression of atherosclerosis in mice.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Biopterins; Carrier Proteins; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Gene Expression Regulation; Hypercholesterolemia; Immunohistochemistry; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Pterins; Receptors, LDL; Tetrahydrofolate Dehydrogenase; Time Factors; Vasodilation; Vasodilator Agents | 2013 |
Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biopterins; Blotting, Western; Brain Chemistry; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromatography, High Pressure Liquid; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout | 2006 |
Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice.
Topics: Administration, Oral; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biopterins; Disease Progression; Endothelium, Vascular; Hypercholesterolemia; Immunohistochemistry; Inflammation Mediators; Mice; Mice, Knockout; RNA, Messenger; Superoxides | 2007 |
A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.
Topics: Analysis of Variance; Animals; Antioxidants; Apolipoproteins E; Ascorbic Acid; Atherosclerosis; Biopterins; Disease Models, Animal; Endothelium, Vascular; Female; GTP Cyclohydrolase; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Probability; Reactive Oxygen Species; Sensitivity and Specificity; Superoxides | 2007 |