Page last updated: 2024-08-21

sapropterin and Alloxan Diabetes

sapropterin has been researched along with Alloxan Diabetes in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.06)	18.7374
1990's	1 (3.03)	18.2507
2000's	16 (48.48)	29.6817
2010's	11 (33.33)	24.3611
2020's	3 (9.09)	2.80

Authors

Authors	Studies
Engineer, A; Feng, Q; Kim, MY; Lim, YJ; Lu, X; Norozi, K	1
Liu, J; Liu, P; Wei, Y; Wu, Y; Xi, W; Yuan, Z; Zhuo, X	1
Abu-Taweel, GM; Ahmed, EI; Allam, AA; Attia, MF; El-Naggar, ME; Galal, HM; Hussein, J; Mekawi, EM	1
Channon, KM; Kashihara, N; Kidokoro, K; Sasaki, T; Satoh, M; Yada, T	1
Abudukadier, A; Fujimoto, S; Fujita, Y; Fukushima, T; Hasegawa, H; Hosokawa, M; Inagaki, N; Nakamura, Y; Obara, A; Ogura, M; Ohashi, A; Sato, Y	1
Channon, KM; Chen, AF; Chen, DD; Chen, LY; Tie, L; Xie, HH	1
Arrick, DM; Mayhan, WG	1
Guo, H; Nie, Y; Wang, J; Yang, Q; Yin, X; Zhang, F; Zhou, X	1
Arakawa, S; Fujimoto, S; Haruna, Y; Horike, H; Kashihara, N; Namikoshi, T; Sasaki, T; Satoh, M; Yada, T	1
Chen, AF; Yang, XQ	1
Channon, KM; Chen, AF; Li, XJ; Tie, L; Wang, X	1
Arellano-Mendoza, MG; Castorena-Torres, F; Coronel, I; del Valle-Mondragon, L; Escalante, B; Rios, A; Romo, E; Vargas-Robles, H	1
Cai, S; Channon, KM; Gangula, PR; Garfield, RE; Mukhopadhyay, S; Pasricha, PJ; Ravella, K	1
Fujita, M; Ito, S; Iwasaka, T; Katano, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
Fujita, M; Iwasaka, T; Jo, F; Jo, H; Kosaki, A; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
Fujita, M; Iwasaka, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
Faria, AM; Lopes de Faria, JB; Lopes de Faria, JM; Papadimitriou, A; Silva, KC	1
Alp, NJ; Cai, S; Channon, KM; Goh, N; Guzik, T; Jefferson, A; Khoo, J; Mussa, S; Rockett, KA	1
Alp, NJ; Bauersachs, J; Cai, S; Channon, KM; Eigenthaler, M; Lygate, CA; Neubauer, S; Schäfer, A	1
Becker, EJ; Cai, S; Channon, KM; Kelly, KA; Meininger, CJ; Parker, JL; Wade, LA; Wood, MK; Wu, G	1
Alp, NJ; Cai, S; Channon, KM; Khoo, J; Mussa, S	1
Akamine, EH; Britto, LR; Carvalho, MH; de Cássia A Tostes, R; Fortes, ZB; Kawamoto, EM; Nigro, D; Scavone, C	1
Bauersachs, J; Ertl, G; Fraccarollo, D; Froese, S; Galuppo, P; Schultheiss, M; Thum, T; Tsikas, D; Widder, JD	1
Song, P; Wang, S; Wu, Y; Xu, J; Zhang, M; Zou, MH	1
Bauersachs, J; Brandt, M; Closs, E; Daiber, A; Ertl, G; Förstermann, U; Münzel, T; Oelze, M; Thum, T; Wenzel, P; Xu, J; Zou, MH	1
Anversa, P; Duan, J; Gao, F; Kajstura, J; Leri, A; Ren, J; Sowers, JR; Sreejayan, N; Thomas, DP; Yang, X	1
Emoto, N; Fukatsu, A; Hayashi, T; Hirata, K; Ikemoto, K; Kawashima, S; Nomura, T; Sasaki, N; Shinohara, M; Shiraki, R; Takaya, T; Takeda, M; Yamashita, T; Yokoyama, M	1
Beirne, E; Donlon, J	1
Donlon, J; Guerin, T; Kaufman, S; Walsh, GA	1
Cringle, SJ; Su, EN; Yu, DY; Yu, PK	1
Kelly, KA; Marinos, RS; Meininger, CJ; Wu, G; Zhang, W	1
Cohen, RA; Shi, C; Zou, MH	1
Blair, JA; Cutler, P; Hamon, CG	1

Other Studies

33 other study(ies) available for sapropterin and Alloxan Diabetes

Article	Year
Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice. Nitric oxide : biology and chemistry, 2020, 01-01, Volume: 94 Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Coronary Artery Disease; Coronary Vessels; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Pregnancy; Streptozocin	2020
Zinc supplementation protects against diabetic endothelial dysfunction via GTP cyclohydrolase 1 restoration. Biochemical and biophysical research communications, 2020, 01-22, Volume: 521, Issue:4 Topics: Animals; Aorta; Biopterins; Cattle; Diabetes Mellitus, Experimental; Dietary Supplements; Endothelium, Vascular; Gene Deletion; Glucose; GTP Cyclohydrolase; Humans; Mice, Inbred C57BL; Reactive Oxygen Species; Zinc	2020
Curcumin nanoparticles have potential antioxidant effect and restore tetrahydrobiopterin levels in experimental diabetes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131 Topics: Animals; Antioxidants; Biopterins; Curcumin; Diabetes Mellitus, Experimental; Drug Stability; Male; Nanoparticles; Particle Size; Rats; Solubility; Streptozocin	2020
Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:7 Topics: Albuminuria; Animals; Biopterins; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Metformin; Mice; Nitric Oxide Synthase Type III; Reactive Oxygen Species	2013
Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice. Diabetes, 2013, Volume: 62, Issue:9 Topics: Animals; Biopterins; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Gluconeogenesis; Hepatocytes; Hypoglycemic Agents; Immunoblotting; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering	2013
GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1. American journal of physiology. Endocrinology and metabolism, 2014, May-15, Volume: 306, Issue:10 Topics: Animals; Biopterins; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Down-Regulation; Endothelial Cells; GTP Cyclohydrolase; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Thrombospondin 1; Wound Healing	2014
Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes. Diabetes & vascular disease research, 2017, Volume: 14, Issue:1 Topics: Animals; Arterioles; Biopterins; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pia Mater; Rats, Sprague-Dawley; Superoxides; Vascular Resistance; Vasodilation; Vasodilator Agents	2017
Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy. The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:2 Topics: Animals; Biopterins; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matrix; Kidney Cortex; Kidney Function Tests; Laminin; Male; Mesangial Cells; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Sugar Acids	2017
Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:12 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Biopterins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA Primers; GTP Cyclohydrolase; Kidney Glomerulus; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger	2008
High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model. Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:8 Topics: Acetophenones; Animals; Biopterins; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelium, Vascular; Enzyme Inhibitors; Genes, Dominant; Insulin; Lipid Peroxides; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; NADPH Oxidases; Oxidative Stress; Protein Precursors; Superoxides; Vasodilation	2009
Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:6 Topics: Animals; Biopterins; Diabetes Mellitus, Experimental; Endothelium; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Superoxides; Wound Healing	2009
L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2010, Volume: 20, Issue:3 Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Inhibitors; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vitamin E	2010
Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:5 Topics: Animals; Biopterins; Blood Glucose; Diabetes Mellitus, Experimental; Female; Gastric Emptying; Gastroparesis; GTP Cyclohydrolase; Hypoxanthines; Male; Muscle Relaxation; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Pylorus; Rats; Rats, Sprague-Dawley	2010
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart. Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:3 Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left	2011
Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:8 Topics: Animals; Biopterins; Cardiotonic Agents; Coenzymes; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Enzyme Inhibitors; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Pterins; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left	2011
Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart. Free radical research, 2011, Volume: 45, Issue:10 Topics: Acetylcysteine; Animals; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2011
Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by re-establishing tetrahydrobiopterin levels. Diabetes, 2012, Volume: 61, Issue:7 Topics: Animals; Antioxidants; Biopterins; Camellia sinensis; Cells, Cultured; Diabetes Mellitus, Experimental; GTP Cyclohydrolase; Humans; Mesangial Cells; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Tea	2012
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. The Journal of clinical investigation, 2003, Volume: 112, Issue:5 Topics: Animals; Biopterins; Diabetes Mellitus, Experimental; Endothelium, Vascular; GTP Cyclohydrolase; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; RNA, Messenger; Streptozocin; Superoxides	2003
Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:9 Topics: Animals; Biopterins; CD40 Ligand; Cell Adhesion Molecules; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fibrinogen; Flow Cytometry; GTP Cyclohydrolase; Mice; Mice, Transgenic; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Protein Processing, Post-Translational; Streptozocin	2004
GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:15 Topics: Animals; Biopterins; Diabetes Mellitus, Experimental; Endothelial Cells; Endothelium, Vascular; Gene Transfer Techniques; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Myocardium; Nitric Oxide; Rats; Rats, Inbred BB; Rats, Zucker; Vasodilation	2004
Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation. Diabetologia, 2005, Volume: 48, Issue:9 Topics: Acetylcholine; Animals; Biopterins; Diabetes Mellitus, Experimental; Dimerization; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroprusside; Phenylephrine; Reference Values; Superoxides	2005
Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin. Journal of vascular research, 2006, Volume: 43, Issue:4 Topics: Acetylcholine; Alloxan; Animals; Biopterins; Diabetes Mellitus, Experimental; Drug Administration Schedule; Female; Hypoglycemic Agents; Insulin; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Sex Factors; Superoxide Dismutase; Vasodilation; Vasodilator Agents	2006
Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes, 2007, Volume: 56, Issue:3 Topics: Aged; Animals; Biopterins; Bone Marrow; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Female; Humans; Male; Nitric Oxide Synthase Type III; Nitroarginine; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Stem Cells	2007
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation, 2007, Aug-21, Volume: 116, Issue:8 Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; GTP Cyclohydrolase; Guanosine Triphosphate; Leupeptins; Mice; Mice, Inbred C57BL; Nitrogen; Organ Culture Techniques; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Spin Labels; Tyrosine; Ubiquitin; Umbilical Veins	2007
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis, 2008, Volume: 198, Issue:1 Topics: Animals; Atorvastatin; Biopterins; Body Weight; Cell Adhesion Molecules; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Male; Microfilament Proteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pyrroles; Rats; Rats, Wistar; Stem Cells; Tetrahydrofolate Dehydrogenase; Vasodilation	2008
IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:3 Topics: Animals; Biopterins; Cardiomyopathies; Cell Separation; Diabetes Mellitus, Experimental; Folic Acid Antagonists; Insulin-Like Growth Factor I; Kv1.2 Potassium Channel; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardial Contraction; Myocytes, Cardiac; Myosin Heavy Chains; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Tetrahydrofolate Dehydrogenase; Ultrasonography	2008
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6 Topics: Animals; Aorta; Biopterins; Carotid Arteries; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; GTP Cyclohydrolase; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Streptozocin; Superoxides	2008
Modulations of rat hepatic phenylalanine hydroxylase due to induced diabetes or high-protein diet. Biochemical and biophysical research communications, 1982, Sep-30, Volume: 108, Issue:2 Topics: Animals; Biopterins; Diabetes Mellitus, Experimental; Dietary Proteins; Insulin; Liver; Male; Phenylalanine Hydroxylase; Phosphorylation; Rats; Rats, Inbred Strains	1982
Correlation of rat hepatic phenylalanine hydroxylase, with tetrahydrobiopterin and GTP concentrations. The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:9 Topics: Animals; Biopterins; Diabetes Mellitus, Experimental; Dietary Sucrose; Fructose; Glycerol; Guanosine Triphosphate; Kinetics; Liver; Male; Nucleotides; Phenylalanine Hydroxylase; Rats; Rats, Sprague-Dawley	1998
Tetrahydrobiopterin reverses the impairment of acetylcholine-induced vasodilatation in diabetic ocular microvasculature. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:2 Topics: Acetylcholine; Animals; Antioxidants; Biopterins; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Rats; Rats, Sprague-Dawley; Retinal Vessels; Vasodilation; Vasodilator Agents	2001
Tetrahydrobiopterin levels regulate endothelial cell proliferation. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:2 Topics: Animals; Biopterins; Cell Division; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Neovascularization, Pathologic; Nitric Oxide; Rats	2001
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. The Journal of clinical investigation, 2002, Volume: 109, Issue:6 Topics: Animals; Antioxidants; Biopterins; Cattle; Cell Line; Detergents; Diabetes Mellitus, Experimental; Dimerization; Endothelium, Vascular; Glucose; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Receptors, LDL; Recombinant Proteins; Sodium Dodecyl Sulfate; Zinc	2002
Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats. Clinica chimica acta; international journal of clinical chemistry, 1989, May-31, Volume: 181, Issue:3 Topics: Animals; Biopterins; Brain; Diabetes Mellitus, Experimental; Dihydropteridine Reductase; Liver; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains	1989