sapropterin has been researched along with Aging in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (18.75) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 16 (50.00) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Abatan, A; Adnot, S; Breau, M; Bréhat, J; Czibik, G; d'Humières, T; Delmont, T; Derumeaux, G; Halfaoui, M; Hatem, S; Liang, H; Marion, O; Martel, C; Mezdari, Z; Morin, D; Murat Altintas, D; Naushad, S; Pini, M; Radu, C; Sarwar, R; Sawaki, D; Suffee, N; Yavari, A; Zhang, Y | 1 |
| Alexander, LM; Kenney, WL; Stanhewicz, AE | 1 |
| Hishioka, N; Hosokawa, T; Kurasaki, M; Minoshima, M; Miyajima, M; Nishimura, R; Numata, T; Saito, T; Tanaka, M | 1 |
| Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D | 1 |
| Holowatz, LA; Kenney, WL; Lang, JA | 2 |
| Delp, MD; Muller-Delp, JM; Reyes, R; Sindler, AL; Wu, G | 1 |
| Rush, JW | 1 |
| Huang, A; Kaley, G; Sun, D; Yang, YM | 1 |
| Calvert, JW; Fleenor, BS; Lefer, DJ; Marshall, KD; Seals, DR; Sindler, AL; Zigler, ML | 1 |
| Habecker, BA; Klein, MG; Li, W; Sundgren, NC; Woodward, WR | 1 |
| Blackwell, KA; Katusic, ZS; Nath, K; Richardson, DM; Smith, LA; Sorenson, JP; Suda, O | 1 |
| Hatakeyama, K; Kalivendi, S; Kalyanaraman, B; Konorev, E; Vásquez-Vivar, J; Whitsett, J | 1 |
| Armato, U; Chiarini, A; Dal Pra, I; Nemeth, EF; Whitfield, JF | 1 |
| Chayama, K; Goto, C; Hara, K; Higashi, Y; Jitsuiki, D; Kimura, M; Nakagawa, K; Noma, K; Oshima, T; Sasaki, S; Yoshizumi, M | 1 |
| Eskurza, I; Kahn, ZD; Myerburgh, LA; Seals, DR | 1 |
| Black, SM; Farrow, KN; Jenkins, C; Konduri, GG; Lakshminrusimha, S; Mata-Greenwood, E; Russell, JA; Steinhorn, RH | 1 |
| Behnke, BJ; Delp, MD; Muller-Delp, JM; Spier, SA; Wu, G | 1 |
| Heffernan, KS; Valentine, RJ; Vieira, VJ | 1 |
| Larocca, TJ; Pierce, GL | 1 |
| Bedja, D; Champion, HC; El-Haddad, H; Gabrielson, K; Misra, V; Mitzner, W; Rabold, R; Takimoto, E; Tankersley, CG | 1 |
| Kapatos, G; Kaufman, S; Klein, DC; Weller, JL | 1 |
| Ballenger, J; Calne, D; Levine, R; Lovenberg, W; Williams, A | 1 |
| Fernell, E; Kanai, T; Långström, B; Tani, Y; Watanabe, Y | 1 |
| Hatakeyama, K; Hoshiga, M; Kagamiyama, H; Shimada, M; Watanabe, M | 1 |
| Azumagawa, K; Mino, M; Suzuki, S | 1 |
| Ashwal, S; Pearce, WJ; Tone, B | 1 |
| Eda, S; Masada, M; Yoshida, YI | 1 |
| Katoh, S; Sueoka, T | 1 |
| Curtius, HC; Leimbacher, W; Niederwieser, A; Shintaku, H | 1 |
| Levine, RA | 1 |
| Anderson, J; Armstrong, RA; Blair, JA | 1 |
2 review(s) available for sapropterin and Aging
| Article | Year |
|---|---|
Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth.
Topics: Aging; Animals; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Muscle, Skeletal; Rats; Vasodilation | 2008 |
Tetrahydrobiopterin and biogenic amine metabolism in neuropsychiatry, immunology, and aging.
Topics: Aging; Animals; Biogenic Amines; Biopterins; Humans; Immune System; Mental Disorders; Neurosecretory Systems; Phenylketonurias; Pterins; Rats | 1988 |
2 trial(s) available for sapropterin and Aging
| Article | Year |
|---|---|
Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.
Topics: Aged; Aging; Arterial Pressure; Biopterins; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Norepinephrine; Propranolol; Reflex; Skin; Skin Aging; Skin Temperature; Tyramine; Vasoconstriction | 2013 |
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.
Topics: Adult; Aged; Aging; Biopterins; Body Constitution; Dose-Response Relationship, Drug; Endothelium, Vascular; Exercise; Humans; Male; Middle Aged; Physical Fitness; Rest; Vasodilation | 2005 |
28 other study(ies) available for sapropterin and Aging
| Article | Year |
|---|---|
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.
Topics: Aging; Amino Acids; Animals; Biomarkers; Biopterins; Catalysis; Cellular Senescence; Disease Models, Animal; Disease Susceptibility; Heart Diseases; Humans; Liver; Male; Mice; Mice, Knockout; Models, Biological; Myocardium; Myocytes, Cardiac; Phenylalanine; Rats | 2021 |
Increase in tetrahydrobiopterin concentration with aging in the cerebral cortex of the senescence-accelerated mouse prone 10 strain caused by abnormal regulation of tetrahydrobiopterin biosynthesis.
Topics: Aging; Animals; Biopterins; Cerebral Cortex; Chromatography, High Pressure Liquid; Mice; Phosphorylation; Tetrahydrofolate Dehydrogenase | 2013 |
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite | 2014 |
Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Biopterins; Body Temperature; Cold Temperature; Female; Humans; Male; Nitric Oxide Synthase; Propranolol; Regional Blood Flow; Skin; Sympathomimetics; Tyramine; Vasoconstriction; Yohimbine | 2009 |
Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles.
Topics: Aging; Animals; Antioxidants; Arterioles; Biopterins; Cyclic N-Oxides; Hydrogen Peroxide; Male; Models, Animal; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type III; Oxygen; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Reactive Oxygen Species; Spin Labels; Vascular Resistance; Vasodilation | 2009 |
Exercising an option to prevent age related decline of vascular BH4 and uncoupling of eNOS.
Topics: Aging; Animals; Arterioles; Biopterins; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type III; Physical Conditioning, Animal; Rats; Reactive Oxygen Species; Regional Blood Flow; Vasomotor System | 2009 |
eNOS uncoupling and endothelial dysfunction in aged vessels.
Topics: Acetylcholine; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Biopterins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Stability; GTP Cyclohydrolase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Pterins; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2009 |
Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.
Topics: Adrenergic Uptake Inhibitors; Aged; Aging; Biopterins; Dose-Response Relationship, Drug; Female; Humans; Male; Norepinephrine; Oxidative Stress; Regional Blood Flow; Skin; Tyramine; Tyrosine; Vasoconstriction; Young Adult | 2010 |
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
Topics: Acetophenones; Acetylcholine; Administration, Oral; Aging; Animals; Biopterins; Carotid Arteries; Cyclic N-Oxides; Cytokines; Elasticity; Endothelium, Vascular; Humans; Male; Mice; Myography; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Sodium Nitrite; Spin Labels; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 2011 |
Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.
Topics: Acetylcholine; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Blotting, Western; Catecholamines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Foot; Mice; Neurons; Neurotransmitter Agents; Norepinephrine; Phenotype; Pteridines; Pterins; Skin; Sweat Glands; Sympathetic Fibers, Postganglionic; Tissue Extracts; Tyrosine 3-Monooxygenase | 2002 |
Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin.
Topics: Acetylcholine; Aging; Animals; Biopterins; C-Reactive Protein; Carotid Arteries; Endothelium, Vascular; GTP Cyclohydrolase; Hydrazines; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidation-Reduction; Serum Amyloid P-Component; Superoxides; Vasodilation; Vasodilator Agents | 2004 |
Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?
Topics: Aging; Animals; Biopterins; Cells, Cultured; Chlorocebus aethiops; Endothelial Cells; Glucose Oxidase; GTP Cyclohydrolase; Heart; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Myocytes, Cardiac; Proteins; Rats; RNA, Messenger | 2005 |
Roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes.
Topics: Adult; Aging; Astrocytes; Biopterins; Calcium; Cations, Divalent; Cell Proliferation; Cytokines; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide; Receptors, Calcium-Sensing | 2005 |
Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production.
Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Aging; Biopterins; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Vasodilation | 2006 |
eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.
Topics: Aging; Animals; Arginine; Biopterins; Calcimycin; Endothelium, Vascular; Enzyme Activation; Fetus; HSP90 Heat-Shock Proteins; Humans; Nitric Oxide Synthase Type III; Pulmonary Artery; Reactive Oxygen Species; Recombinant Proteins; Sheep; Stress, Mechanical; Superoxides; Vascular Endothelial Growth Factor A; Vasodilation | 2006 |
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.
Topics: Aging; Animals; Arginase; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Rats; Rats, Inbred F344; Vasodilation | 2008 |
Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
Topics: Administration, Oral; Aging; Animals; Biopterins; Endothelium, Vascular; Nitric Oxide; Rats | 2008 |
Exposure to inhaled particulate matter impairs cardiac function in senescent mice.
Topics: Administration, Inhalation; Aging; Animals; Biopterins; Blood Pressure; Echocardiography; Environmental Exposure; Gene Expression Regulation; Heart; Heart Diseases; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Myocardium; Nitric Oxide Synthase; Particulate Matter; Reactive Oxygen Species; Reproducibility of Results; Stroke Volume; Time Factors | 2008 |
The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland.
Topics: Aging; Aminohydrolases; Animals; Biopterins; Brain; Female; GTP Cyclohydrolase; Male; Organ Specificity; Pineal Gland; Pteridines; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Aging and CSF hydroxylase cofactor.
Topics: Adult; Aged; Aging; Biopterins; Humans; Middle Aged; Parkinson Disease; Pteridines | 1980 |
Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients.
Topics: Adolescent; Adult; Aging; Autistic Disorder; Biopterins; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Male; Neopterin | 1994 |
Autoradiographic distribution of [14C]tetrahydrobiopterin and its developmental change in mice.
Topics: Aging; Animals; Autoradiography; Biopterins; Carbon Radioisotopes; Female; Fetus; GTP Cyclohydrolase; Liver; Male; Mice; Oxidation-Reduction; Phenylalanine Hydroxylase; Pregnancy; Time Factors; Tissue Distribution | 1993 |
Developmental changes of tetrahydrobiopterin in rat and human erythrocytes.
Topics: Adolescent; Adult; Aging; Animals; Biopterins; Cell Membrane Permeability; Child; Child, Preschool; Erythrocyte Membrane; Erythrocytes; Female; GTP Cyclohydrolase; Humans; Infant; Infant, Newborn; Male; Rats; Rats, Wistar | 1995 |
Maturation alters cerebral NOS kinetics in the spontaneously hypertensive rat.
Topics: Aging; Animals; Animals, Newborn; Biopterins; Brain; Calmodulin; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hypertension; Kinetics; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 1997 |
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.
Topics: Aging; Animals; Animals, Newborn; Biopterins; Body Weight; Brain; Growth; Kidney; Liver; Mice; Mice, Inbred ICR; Organ Size; Pteridines | 2000 |
Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats.
Topics: Aging; Aminohydrolases; Animals; Biopterins; GTP Cyclohydrolase; Kinetics; Male; Pteridines; Rats; Rats, Inbred Strains; Salivary Glands; Tyrosine 3-Monooxygenase | 1986 |
Tetrahydrobiopterin deficiency: assay for 6-pyruvoyl-tetrahydropterin synthase activity in erythrocytes, and detection of patients and heterozygous carriers.
Topics: Adult; Aging; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Infant; Middle Aged; Multienzyme Complexes | 1988 |
The effect of age on tetrahydrobiopterin metabolism in the human brain.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biopterins; Frontal Lobe; Humans; Middle Aged; Temporal Lobe | 1987 |