sappanchalcone has been researched along with Lymphedema* in 1 studies
1 other study(ies) available for sappanchalcone and Lymphedema
| Article | Year |
|---|---|
Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema.
Herein, we demonstrate that butein (1) can prevent swelling in a murine lymphedema model by suppressing tumor necrosis factor α (TNF-α) production. Butein derivatives were synthesized and evaluated to identify compounds with in vitro anti-inflammatory activity. Among them, 20 μM of compounds 7j, 7m, and 14a showed 50% suppression of TNF-α production in mouse peritoneal macrophages after lipopolysaccharide stimulation. Compound 14a, exhibited the strongest potency with an in vitro IC Topics: Animals; Anti-Inflammatory Agents; Chalcones; Humans; Lipopolysaccharides; Lymphedema; Macrophages, Peritoneal; Mice; Microsomes, Liver; Prodrugs; Rats; Tumor Necrosis Factor-alpha | 2020 |