sapogenins and Nasopharyngeal-Neoplasms

sapogenins has been researched along with Nasopharyngeal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for sapogenins and Nasopharyngeal-Neoplasms

Article	Year
New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity. Journal of natural products, 2003, Volume: 66, Issue:2 Seven new compounds, including three new flavans [tupichinol A-C (1-3)], three new spirostanol sapogenins [tupichigenin D-F (4-6)], and one new pregnane genin [tupipregnenolone (7)], together with 18 known compounds, were isolated from the underground parts of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. The structures and relative stereochemistry of 1 and 9 were further confirmed by single-crystal X-ray crystallographic analysis. Compounds Delta(25(27))-pentrogenin, 10, and ranmogenin A showed 100%, 96%, and 80% inhibition, respectively, against human gastric tumor (NUGC) cells at a concentration of 50 microM. Delta(25(27))-pentrogenin showed 100% inhibition against human nasopharyngeal carcinoma (HONE-1) cells at a concentration of 50 microM. Topics: Antineoplastic Agents, Phytogenic; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavonoids; Humans; Liliaceae; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Pregnanes; Sapogenins; Stereoisomerism; Stomach Neoplasms; Taiwan; Tumor Cells, Cultured	2003

Article

Year

New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity.

Journal of natural products, 2003, Volume: 66, Issue:2

Seven new compounds, including three new flavans [tupichinol A-C (1-3)], three new spirostanol sapogenins [tupichigenin D-F (4-6)], and one new pregnane genin [tupipregnenolone (7)], together with 18 known compounds, were isolated from the underground parts of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. The structures and relative stereochemistry of 1 and 9 were further confirmed by single-crystal X-ray crystallographic analysis. Compounds Delta(25(27))-pentrogenin, 10, and ranmogenin A showed 100%, 96%, and 80% inhibition, respectively, against human gastric tumor (NUGC) cells at a concentration of 50 microM. Delta(25(27))-pentrogenin showed 100% inhibition against human nasopharyngeal carcinoma (HONE-1) cells at a concentration of 50 microM.

Topics: Antineoplastic Agents, Phytogenic; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavonoids; Humans; Liliaceae; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Pregnanes; Sapogenins; Stereoisomerism; Stomach Neoplasms; Taiwan; Tumor Cells, Cultured

2003