sapogenins and Cholangitis

sapogenins has been researched along with Cholangitis* in 1 studies

Other Studies

1 other study(ies) available for sapogenins and Cholangitis

Article	Year
Isolation of steroidal sapogenins implicated in experimentally induced cholangiopathy of sheep grazing Brachiaria decumbens in Brazil. Veterinary and human toxicology, 2000, Volume: 42, Issue:3 As part of an experimental study, crystal-associated cholangiopathy was induced in 9 sheep by grazing pure pastures of Brachiaria decumbens in Brazil. One of these sheep showed characteristic lesions of photosensitization. The analysis of the B decumbens samples by acidic hydrolysis followed by TLC and infrared spectrum revealed diosgenin as the principal sapogenin present in the plant. In the rumen contents samples from the B decumbens-grazing group were identified by TLC, 1H and 13C NMR and EIMS as epismilagenin, episarsasapogenin, and a mixture of smilagenin and sarsasapogenin. In the bile samples from the B decumbens-grazing group, TLC analysis demonstrated 2 compounds similar to epismilagenin and episarsasapogenin. However, by this same method, those compounds were not observed in the rumen contents and bile from 2 sheep which served as control animals. The P chartarum spore counts remained very low during the experimental period. Topics: Animals; Ascomycota; Bile; Brazil; Cholangitis; Chromatography, Thin Layer; Colony Count, Microbial; Diosgenin; Histocytochemistry; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Photosensitivity Disorders; Poaceae; Rumen; Sapogenins; Sheep; Sheep Diseases; Spectrophotometry, Infrared; Spirostans; Spores, Fungal	2000

Article

Year

Isolation of steroidal sapogenins implicated in experimentally induced cholangiopathy of sheep grazing Brachiaria decumbens in Brazil.

Veterinary and human toxicology, 2000, Volume: 42, Issue:3

As part of an experimental study, crystal-associated cholangiopathy was induced in 9 sheep by grazing pure pastures of Brachiaria decumbens in Brazil. One of these sheep showed characteristic lesions of photosensitization. The analysis of the B decumbens samples by acidic hydrolysis followed by TLC and infrared spectrum revealed diosgenin as the principal sapogenin present in the plant. In the rumen contents samples from the B decumbens-grazing group were identified by TLC, 1H and 13C NMR and EIMS as epismilagenin, episarsasapogenin, and a mixture of smilagenin and sarsasapogenin. In the bile samples from the B decumbens-grazing group, TLC analysis demonstrated 2 compounds similar to epismilagenin and episarsasapogenin. However, by this same method, those compounds were not observed in the rumen contents and bile from 2 sheep which served as control animals. The P chartarum spore counts remained very low during the experimental period.

Topics: Animals; Ascomycota; Bile; Brazil; Cholangitis; Chromatography, Thin Layer; Colony Count, Microbial; Diosgenin; Histocytochemistry; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Photosensitivity Disorders; Poaceae; Rumen; Sapogenins; Sheep; Sheep Diseases; Spectrophotometry, Infrared; Spirostans; Spores, Fungal

2000