santonin and Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma

Background: Acute lymphoblastic leukemia (ALL) is one of the most dominant malignancies among children,\ characterized by production of immature and dysfunctional blasts which are resistant to cytotoxic chemotherapeutic\ agents. Therefore, research protocols are currently focusing on discovery of novel anti-cancer agents to enhance survival\ rates and decrease unwanted side effects. Approximately two-thirds of the planet is covered by oceans with a massive\ range of marine organisms of interest to scientists in pharmaceutical fields. Methods: Among marine resources, sponges\ are known to have beneficial effects in the treatment of numerous malignancies. One fraction of crude extracts containing\ α-Santonin was made from the Persian Gulf marine sponge, Dysidea avara, and investigated for anticancer effects.\ Results: Treatment of ALL B-lymphocytes with the Dysidea avara extract caused augmentation in ROS generation,\ decline in mitochondrial membrane potential, mitochondrial swelling, release of cytochrome c from mitochondria\ and activation of caspase-3 only in mitochondria isolated from B-ALL lymphocytes. Conclusion: In brief, our results\ suggest that Dysidea avara extracts may selectively induce apoptosis in malignant pediatric lymphocytes.

Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cell Proliferation; Child; Cytochromes c; Dysidea; Humans; Indian Ocean; Membrane Potential, Mitochondrial; Mitochondria; Porifera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Santonin; Tumor Cells, Cultured