sanguinarine has been researched along with Pancreatic Neoplasms in 5 studies
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to determine the potential of sanguinarine, a plant alkaloid known to possess strong antimicrobial, anti-inflammatory, and antioxidant activities, against human pancreatic carcinoma cells." | 7.74 | Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins. ( Ahmad, N; Ahsan, H; Breur, J; Reagan-Shaw, S, 2007) |
| "The human pancreatic carcinoid cell line, BON-1, human typical bronchial carcinoid cell line NCI-H727 and the human atypical bronchial carcinoid cell line NCI-H720 were tested." | 5.36 | The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. ( Granberg, D; Hassan, S; Larsson, DE; Oberg, K; Wickström, M, 2010) |
| " This study was designed to determine the potential of sanguinarine, a plant alkaloid known to possess strong antimicrobial, anti-inflammatory, and antioxidant activities, against human pancreatic carcinoma cells." | 3.74 | Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins. ( Ahmad, N; Ahsan, H; Breur, J; Reagan-Shaw, S, 2007) |
| "Sanguinarine treatment also caused down-regulation of HIF1α and PCNA, and increased cleavage of PARP and Caspase-7." | 1.42 | Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach. ( Ahmad, N; George, J; Kaur, S; Nihal, M; Pellitteri Hahn, MC; Scarlett, CO; Singh, CK, 2015) |
| "majus extracts were evaluated on human cancer cell lines, i." | 1.42 | In vitro and in vivo investigations on the antitumour activity of Chelidonium majus. ( Apers, S; Capistrano I, R; Gravekamp, C; Lardon, F; Pieters, L; Wouters, A, 2015) |
| "The human pancreatic carcinoid cell line, BON-1, human typical bronchial carcinoid cell line NCI-H727 and the human atypical bronchial carcinoid cell line NCI-H720 were tested." | 1.36 | The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. ( Granberg, D; Hassan, S; Larsson, DE; Oberg, K; Wickström, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, Y | 1 |
| Yu, W | 1 |
| Shrivastava, A | 1 |
| Alemi, F | 1 |
| Lankachandra, K | 1 |
| Srivastava, RK | 1 |
| Shankar, S | 1 |
| Singh, CK | 1 |
| Kaur, S | 1 |
| George, J | 1 |
| Nihal, M | 1 |
| Pellitteri Hahn, MC | 1 |
| Scarlett, CO | 1 |
| Ahmad, N | 2 |
| Capistrano I, R | 1 |
| Wouters, A | 1 |
| Lardon, F | 1 |
| Gravekamp, C | 1 |
| Apers, S | 1 |
| Pieters, L | 1 |
| Larsson, DE | 1 |
| Wickström, M | 1 |
| Hassan, S | 1 |
| Oberg, K | 1 |
| Granberg, D | 1 |
| Ahsan, H | 1 |
| Reagan-Shaw, S | 1 |
| Breur, J | 1 |
5 other studies available for sanguinarine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Line, Tumor; Cell Proliferatio | 2017 |
Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach.
Topics: Benzophenanthridines; Cell Line, Tumor; Humans; Immunoblotting; Isoquinolines; Pancreatic Neoplasms; | 2015 |
In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Berberine Alkaloids; Ce | 2015 |
The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro.
Topics: Apoptosis; Benzophenanthridines; Boronic Acids; Bortezomib; Brefeldin A; Carcinoid Tumor; Carcinoma, | 2010 |
Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins.
Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Carcinoma; Cell C | 2007 |