sanguinarine has been researched along with Neoplasms in 10 studies
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, its low chemical stability and poor oral bioavailability remain key issues in its use as a medicinal molecule." | 3.01 | Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment. ( Aziz, T; Nawaz, T; Ullah, A; Ullah, N, 2023) |
| "Sanguinarine is a natural compound with good development value for its potent anticancer activity; however, its carcinogenesis effect should also be taken seriously." | 2.72 | Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect. ( Gan, Q; Hu, J; Huang, Q; Lou, G; Peng, C; Wang, J; Xiong, H, 2021) |
| "Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies." | 2.55 | Molecular targets and anticancer potential of sanguinarine-a benzophenanthridine alkaloid. ( Galadari, S; Pallichankandy, S; Rahman, A; Thayyullathil, F, 2017) |
| "majus extracts were evaluated on human cancer cell lines, i." | 1.42 | In vitro and in vivo investigations on the antitumour activity of Chelidonium majus. ( Apers, S; Capistrano I, R; Gravekamp, C; Lardon, F; Pieters, L; Wouters, A, 2015) |
| "Sanguinarine was the most cytotoxic alkaloid against CEM/ADR5000, MCF-7, and CCRF-CEM cells alone and in combination with digitonin." | 1.38 | Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells. ( Eid, SY; El-Readi, MZ; Wink, M, 2012) |
| "We determined the ability of some phytochemicals, including alkaloids (glaucine, harmine, and sanguinarine), phenolics (EGCG and thymol), and terpenoids (menthol, aromadendrene, β-sitosterol-O-glucoside, and β-carotene), alone or in combination with the saponin digitonin to reverse the relative multi-drug resistance of Caco-2 and CEM/ADR5000 cells to the chemotherapeutical agent doxorubicin." | 1.38 | Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells. ( Eid, SY; El-Readi, MZ; Wink, M, 2012) |
| "Here, we examined its potency as an anticancer drug." | 1.32 | Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion. ( Barthomeuf, C; Debiton, E; Legault, J; Madelmont, JC, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joshi, P | 1 |
| Vishwakarma, RA | 1 |
| Bharate, SB | 1 |
| Ullah, A | 1 |
| Ullah, N | 1 |
| Nawaz, T | 1 |
| Aziz, T | 1 |
| Lou, G | 1 |
| Wang, J | 1 |
| Hu, J | 1 |
| Gan, Q | 1 |
| Peng, C | 1 |
| Xiong, H | 1 |
| Huang, Q | 1 |
| Galadari, S | 1 |
| Rahman, A | 1 |
| Pallichankandy, S | 1 |
| Thayyullathil, F | 1 |
| Fu, C | 1 |
| Guan, G | 1 |
| Wang, H | 1 |
| Capistrano I, R | 1 |
| Wouters, A | 1 |
| Lardon, F | 1 |
| Gravekamp, C | 1 |
| Apers, S | 1 |
| Pieters, L | 1 |
| Eid, SY | 2 |
| El-Readi, MZ | 2 |
| Wink, M | 2 |
| Debiton, E | 1 |
| Madelmont, JC | 1 |
| Legault, J | 1 |
| Barthomeuf, C | 1 |
| Vogt, A | 1 |
| Tamewitz, A | 1 |
| Skoko, J | 1 |
| Sikorski, RP | 1 |
| Giuliano, KA | 1 |
| Lazo, JS | 1 |
5 reviews available for sanguinarine and Neoplasms
| Article | Year |
|---|---|
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member | 2017 |
Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment.
Topics: Antineoplastic Agents; Benzophenanthridines; Humans; Isoquinolines; MicroRNAs; Neoplasms; Signal Tra | 2023 |
Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect.
Topics: Antineoplastic Agents; Benzophenanthridines; Carcinogens; Cell Proliferation; Humans; Isoquinolines; | 2021 |
Molecular targets and anticancer potential of sanguinarine-a benzophenanthridine alkaloid.
Topics: Animals; Antineoplastic Agents; Benzophenanthridines; Cell Death; Cell Line, Tumor; Drug Evaluation, | 2017 |
The Anticancer Effect of Sanguinarine: A Review.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzophenanthridines; Cell Proliferation; Hum | 2018 |
5 other studies available for sanguinarine and Neoplasms
| Article | Year |
|---|---|
In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Berberine Alkaloids; Ce | 2015 |
Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member | 2012 |
Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells.
Topics: Alkaloids; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Caco-2 Ce | 2012 |
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Benzimidazoles; Benzophenanthridines; Caspa | 2003 |
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.
Topics: Alkaloids; Benzophenanthridines; Catalytic Domain; cdc25 Phosphatases; Cell Cycle Proteins; Cell Lin | 2005 |