sanguinarine has been researched along with Melanoma in 2 studies
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sanguinarine treatment also induced an increase in intracellular calcium concentration, which was inhibited by dantrolene, and promoted cleavage of BAP-31, thus suggesting a putative role for Ca(2+) release from endoplasmic reticulum and a cross-talk between endoplasmic reticulum and mitochondria in the anti-melanoma action of sanguinarine." | 5.39 | Rapid human melanoma cell death induced by sanguinarine through oxidative stress. ( Bento, AC; Burgeiro, A; Gajate, C; Mollinedo, F; Oliveira, PJ, 2013) |
| "Sanguinarine treatment also induced an increase in intracellular calcium concentration, which was inhibited by dantrolene, and promoted cleavage of BAP-31, thus suggesting a putative role for Ca(2+) release from endoplasmic reticulum and a cross-talk between endoplasmic reticulum and mitochondria in the anti-melanoma action of sanguinarine." | 1.39 | Rapid human melanoma cell death induced by sanguinarine through oxidative stress. ( Bento, AC; Burgeiro, A; Gajate, C; Mollinedo, F; Oliveira, PJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burgeiro, A | 1 |
| Bento, AC | 1 |
| Gajate, C | 1 |
| Oliveira, PJ | 1 |
| Mollinedo, F | 1 |
| Kemény-Beke, A | 1 |
| Aradi, J | 1 |
| Damjanovich, J | 1 |
| Beck, Z | 1 |
| Facskó, A | 1 |
| Berta, A | 1 |
| Bodnár, A | 1 |
2 other studies available for sanguinarine and Melanoma
| Article | Year |
|---|---|
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; bcl-X Protein; Benzophenanthridines; Calcium; Caspase 3; Casp | 2013 |
Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine.
Topics: Alkaloids; Annexin A5; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Berberine Alkaloids; | 2006 |