sanguinarine has been researched along with Leukemia in 5 studies
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The vinblastin-resistant, Pgp positive CEM-VLB 1000 and its wild type (Pgp-negative and vinblastin-sensitive) counterpart CEM-T4 human leukemia cells, when treated with the alkaloid sanguinarine, were both found to undergo apoptosis at concentrations of 1." | 3.73 | Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells. ( Hallock, S; Liepins, A; Tang, SC; Trump, B; Weerasinghe, P, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eid, SY | 1 |
| El-Readi, MZ | 1 |
| Eldin, EE | 1 |
| Fatani, SH | 1 |
| Wink, M | 1 |
| Rahman, A | 1 |
| Thayyullathil, F | 1 |
| Pallichankandy, S | 1 |
| Galadari, S | 1 |
| Weerasinghe, P | 2 |
| Buja, LM | 1 |
| Hallock, S | 1 |
| Tang, SC | 1 |
| Trump, B | 1 |
| Liepins, A | 1 |
| Kaminskyy, V | 1 |
| Lin, KW | 1 |
| Filyak, Y | 1 |
| Stoika, R | 1 |
1 review available for sanguinarine and Leukemia
| Article | Year |
|---|---|
Oncosis: an important non-apoptotic mode of cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Death; Cell Enlargement; Human | 2012 |
4 other studies available for sanguinarine and Leukemia
| Article | Year |
|---|---|
Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine.
Topics: Apoptosis; Benzophenanthridines; Cell Line, Tumor; Ceramides; DNA Fragmentation; Gene Expression Reg | 2016 |
Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells.
Topics: Alkaloids; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-2-Associated X Pr | 2006 |
Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Benzophenanthridines; Cell Line, Tumor; Cell | 2008 |