sanguinarine and Gingivitis studies

benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.

Gingivitis: Inflammation of gum tissue (GINGIVA) without loss of connective tissue.

Research Excerpts

Excerpt	Relevance	Reference
"2% or sanguinarine on gingivitis affecting orthodontically banded first molars in adolescent patients."	9.08	Subgingival irrigation effects of chlorhexidine or sanguinarine on gingivitis in orthodontic patients. ( Al Jasser, N; Babay, N, 1996)
"Some studies showed positive results in testing the efficacy of sanguinarine delivered as oral rinse or dentifrice against plaque and gingivitis."	9.06	[Evaluation of the efficacy of sanguinarine using the experimental gingivitis model]. ( Gängler, P; Kaufmann, K; Kurbad, A, 1990)
"The present clinical trial was performed to assess the effect of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis in man."	9.05	Some effects of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis. ( Lindhe, J; Wennström, J, 1985)
"Sanguinarine-containing toothpaste and oral rinse significantly inhibited the redevelopment of gingivitis through the 12 weeks following the chlorhexidine phase compared to the control toothpaste and rinse."	5.09	Effectiveness of a sanguinarine regimen after scaling and root planing. ( Dahan, M; Soell, M; Tenenbaum, H, 1999)
"2% or sanguinarine on gingivitis affecting orthodontically banded first molars in adolescent patients."	5.08	Subgingival irrigation effects of chlorhexidine or sanguinarine on gingivitis in orthodontic patients. ( Al Jasser, N; Babay, N, 1996)
"Some studies showed positive results in testing the efficacy of sanguinarine delivered as oral rinse or dentifrice against plaque and gingivitis."	5.06	[Evaluation of the efficacy of sanguinarine using the experimental gingivitis model]. ( Gängler, P; Kaufmann, K; Kurbad, A, 1990)
"A clinical trial was conducted to evaluate the effects of a sanguinaria-zinc chloride dentifrice on the prevention of plaque formation and gingivitis."	5.06	Clinical effect of a sanguinaria dentifrice on plaque and gingivitis in adults. ( Beiswanger, BB; Bricker, SL; Drook, CA; Jackson, RD; Mallatt, ME; Stookey, GK, 1989)
"2% chlorhexidine mouthrinse (Corsodyl) with a sanguinarine-zinc mouthrinse (Veadent) to inhibit plaque and gingivitis."	5.06	A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl). ( Addy, M; Moran, J; Newcombe, R, 1988)
"The present clinical trial was performed to assess the effect of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis in man."	5.05	Some effects of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis. ( Lindhe, J; Wennström, J, 1985)
" For gingivitis, control supragingival irrigation with sanguinarine and with water were statistically different from manual rinsing with sanguinaria."	3.67	Effect of sanguinaria extract on established plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. ( Jones, BJ; Parsons, LG; Southard, GL; Thomas, LG; Woodall, IR, 1987)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (51.22)	18.7374
1990's	18 (43.90)	18.2507
2000's	1 (2.44)	29.6817
2010's	1 (2.44)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Vlachojannis, C	1
Magora, F	1
Chrubasik, S	1
Paraskevas, S	1
Lindhe, J	3
Klewansky, P	1
Vernier, D	1
Firatli, E	1
Unal, T	1
Onan, U	1
Sandalli, P	1
Simard, F	1
Landry, RG	1
Yiu, CK	1
Wei, SH	1
Babay, N	1
Al Jasser, N	1
Cullinan, MP	1
Powell, RN	1
Faddy, MJ	1
Seymour, GJ	1
Tenenbaum, H	1
Dahan, M	1
Soell, M	1
Otomo-Corgel, J	1
Greenstein, G	1
Kopczyk, RA	2
Abrams, H	1
Brown, AT	1
Matheny, JL	1
Kaplan, AL	1
Rubinstein-DeVore, L	1
McIntosh, M	1
Birek, P	1
Kocher, T	1
Bössmann, K	1
Rees, H	1
Miller, NA	1
Laurent, P	1
Bruant, A	1
Pierrat, C	1
Martin, G	1
Harper, DS	1
Mueller, LJ	1
Fine, JB	1
Gordon, J	1
Laster, LL	2
Lobene, RR	2
Kuftinec, MM	2
Mueller-Joseph, LJ	1
Willershausen, B	1
Gruber, I	1
Hamm, G	1
Obtmeier, R	1
Kurbad, A	1
Gängler, P	1
Kaufmann, K	1
Turnbull, RS	1
Grossman, E	1
Meckel, AH	1
Isaacs, RL	1
Ferretti, GA	1
Sturzenberger, OP	1
Bollmer, BW	1
Moore, DJ	1
Lijana, RC	1
Manhart, MD	1
Gunsolley, JC	3
Chinchilli, VM	1
Koertge, TE	1
Palcanis, KG	2
Sarbin, AG	1
Brooks, CN	2
Mallatt, ME	1
Beiswanger, BB	1
Drook, CA	1
Stookey, GK	1
Jackson, RD	1
Bricker, SL	1
Hannah, JJ	1
Johnson, JD	1
Moran, J	1
Addy, M	1
Newcombe, R	1
Miller, RA	2
McIver, JE	1
Mauriello, SM	1
Bader, JD	1
Formica, JV	1
Soparkar, PM	1
Newman, MB	1
Parsons, LG	4
Thomas, LG	4
Woodall, IR	4
Jones, BJ	4
Wennstrom, J	2
Gross, KB	1
Overman, PR	1
Clark, BR	1
Eberhart, A	1
Love, J	1
Swanbom, DD	1
Davison, CO	1
Southard, GL	3
Boulware, RT	1
Keogh, TP	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Effect on Nonsurgical Periodontal Therapy on First Molars Banded for Fixed Orthodontic Treatment[NCT03410602]			Phase 1	30 participants (Actual)	Interventional	2016-04-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Rise and fall of oral health products with Canadian bloodroot extract. Phytotherapy research : PTR, 2012, Volume: 26, Issue:10 Topics: Benzophenanthridines; Dental Plaque; Gingivitis; Humans; Isoquinolines; Leukoplakia; Mouth Mucosa; M	2012
Randomized controlled clinical trials on agents used for chemical plaque control. International journal of dental hygiene, 2005, Volume: 3, Issue:4 Topics: Alkaloids; Anti-Infective Agents, Local; Benzophenanthridines; Cetylpyridinium; Chlorhexidine; Denta	2005
Mouthrinses as an antibacterial adjunct in periodontal treatment. Journal (Canadian Dental Association), 1994, Volume: 60, Issue:10 Topics: Alkaloids; Benzoates; Benzophenanthridines; Benzydamine; Cetylpyridinium; Chlorhexidine; Dental Plaq	1994
Clinical efficacy of dentifrices in the control of calculus, plaque, and gingivitis. Quintessence international (Berlin, Germany : 1985), 1993, Volume: 24, Issue:3 Topics: Alkaloids; Benzophenanthridines; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; Dental Pl	1993
Over-the-counter and prescription mouthwashes-an update for the 1990s. Compendium (Newtown, Pa.), 1992, Volume: 13, Issue:12 Topics: Alkaloids; American Dental Association; Anti-Infective Agents, Local; Benzophenanthridines; Cariosta	1992
Supragingival and subgingival irrigation: practical application in the treatment of periodontal diseases. Compendium (Newtown, Pa.), 1992, Volume: 13, Issue:12 Topics: Alkaloids; Bacteremia; Benzophenanthridines; Chlorhexidine; Dental Devices, Home Care; Dental Plaque	1992
Antimicrobials and oral health. Seminars in dental hygiene, 1991, Volume: 3, Issue:2 Topics: Alkaloids; Anti-Infective Agents; Benzophenanthridines; Chlorhexidine; Dental Plaque; Gingivitis; Hu	1991
Chemotherapeutic mouthrinses. University of Toronto dental journal, 1991,Spring, Volume: 4, Issue:2 Topics: Alkaloids; Benzoates; Benzophenanthridines; Chlorhexidine; Dental Plaque; Drug Combinations; Gingivi	1991
New perspectives on Sanguinaria clinicals: individual toothpaste and oral rinse testing. Journal (Canadian Dental Association), 1990, Volume: 56, Issue:7 Suppl Topics: Alkaloids; Anti-Infective Agents; Benzophenanthridines; Bias; Chlorhexidine; Clinical Trials as Topi	1990
Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. Journal (Canadian Dental Association), 1990, Volume: 56, Issue:7 Suppl Topics: Alkaloids; Analysis of Variance; Anti-Infective Agents; Benzophenanthridines; Chi-Square Distributio	1990
Chemotherapeutic control of plaque and gingivitis. Journal (Canadian Dental Association), 1989, Volume: 55, Issue:12 Topics: Alkaloids; Anti-Infective Agents; Benzophenanthridines; Chlorhexidine; Dental Plaque; Drug Combinati	1989

Article	Year
Subgingival irrigation effects of chlorhexidine or sanguinarine on gingivitis in orthodontic patients. The Journal of clinical pediatric dentistry, 1996,Spring, Volume: 20, Issue:3 Topics: Adolescent; Alkaloids; Analysis of Variance; Anti-Infective Agents, Local; Benzophenanthridines; Chi	1996
Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Australian dental journal, 1997, Volume: 42, Issue:1 Topics: Adult; Aged; Alkaloids; Benzophenanthridines; Dental Plaque; Dental Plaque Index; Dental Scaling; De	1997
Effectiveness of a sanguinarine regimen after scaling and root planing. Journal of periodontology, 1999, Volume: 70, Issue:3 Topics: Adult; Aged; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Chemoprevention; Chlorhexidine;	1999
Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 months of use. Journal of periodontology, 1991, Volume: 62, Issue:10 Topics: Adult; Alkaloids; Anti-Bacterial Agents; Bacteria; Benzophenanthridines; Colony Count, Microbial; De	1991
[Sanguinarine preparations to aid mechanical tooth cleansing]. Deutsche zahnarztliche Zeitschrift, 1990, Volume: 45, Issue:12 Topics: Adolescent; Adult; Alkaloids; Benzophenanthridines; Dental Plaque; Dental Plaque Index; Dentifrices;	1990
Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. Journal of periodontology, 1990, Volume: 61, Issue:6 Topics: Adult; Alkaloids; Analysis of Variance; Anti-Infective Agents; Benzophenanthridines; Chlorides; Clin	1990
[Evaluation of the efficacy of sanguinarine using the experimental gingivitis model]. Stomatologie der DDR, 1990, Volume: 40, Issue:4 Topics: Adult; Alkaloids; Benzophenanthridines; Chlorhexidine; Dental Plaque; Gingivitis; Humans; Isoquinoli	1990
A clinical comparison of antibacterial mouthrinses: effects of chlorhexidine, phenolics, and sanguinarine on dental plaque and gingivitis. Journal of periodontology, 1989, Volume: 60, Issue:8 Topics: Adult; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Chlorhexidine; Clinical Trials as Top	1989
Clinical effect of a sanguinaria dentifrice on plaque and gingivitis in adults. Journal of periodontology, 1989, Volume: 60, Issue:2 Topics: Adolescent; Adult; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Chlorides; Dental Plaque;	1989
Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 1989, Volume: 96, Issue:3 Topics: Adolescent; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Dental Plaque; Dentifrices; Doub	1989
A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl). Journal of clinical periodontology, 1988, Volume: 15, Issue:10 Topics: Adult; Alkaloids; Benzophenanthridines; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Fema	1988
Six-month effects of a sanguinarine dentifrice on plaque and gingivitis. Journal of periodontology, 1988, Volume: 59, Issue:4 Topics: Adult; Alkaloids; Benzophenanthridines; Clinical Trials as Topic; Dental Plaque; Dentifrices; Double	1988
The relationship of sanguinaria extract concentration and zinc ion to plaque and gingivitis. Journal of clinical periodontology, 1987, Volume: 14, Issue:6 Topics: Adult; Alkaloids; Benzophenanthridines; Dental Plaque; Dental Plaque Index; Female; Gingivitis; Huma	1987
Effect of sanguinaria extract on development of plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. Journal of clinical periodontology, 1987, Volume: 14, Issue:7 Topics: Adult; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Dental Devices, Home Care; Dental Pla	1987
Some effects of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis. Journal of clinical periodontology, 1985, Volume: 12, Issue:10 Topics: Adult; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Clinical Trials as Topic; Dental Plaq	1985

sanguinarine and Gingivitis

Research Excerpts

Research

Studies (41)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Clinical assessment of antiplaque agents. The Compendium of continuing education in dentistry, 1984, Volume: Suppl 5 Topics: Alkaloids; Benzophenanthridines; Dental Plaque; Gingiva; Gingivitis; Humans; Isoquinolines	1984
Sanguinarine and the control of plaque in dental practice. The Compendium of continuing education in dentistry, 1984, Volume: Suppl 5 Topics: Adult; Aged; Alkaloids; Benzophenanthridines; Dental Plaque; Female; Gingivitis; Humans; Isoquinolin	1984
Antioxidative activities of some chemotherapeutics. A possible mechanism in reducing gingival inflammation. Journal of clinical periodontology, 1994, Volume: 21, Issue:10 Topics: Alkaloids; Animals; Anti-Infective Agents, Local; Antioxidants; Benzophenanthridines; Brain; Cattle;	1994
[Effect of a sanguinarine mouthwash on children with and without upper extremity motor handicap]. Journal de parodontologie, 1990, Volume: 9, Issue:1 Topics: Adolescent; Alkaloids; Benzophenanthridines; Child; Dental Care for Disabled; Dental Plaque; Dental	1990
[Action of different mouthwash solutions on infection rate of gingiva --study with army recruits]. Die Quintessenz, 1990, Volume: 41, Issue:8 Topics: Adolescent; Adult; Alkaloids; Benzophenanthridines; Chlorhexidine; Dental Plaque; DMF Index; Germany	1990
The use of repeated measures analysis of variance for plaque and gingival indices. Journal of clinical periodontology, 1989, Volume: 16, Issue:3 Topics: Alkaloids; Analysis of Variance; Anti-Infective Agents; Benzophenanthridines; Dental Health Surveys;	1989
Effects of sanguinaria extract on plaque retention and gingival health. Journal of clinical orthodontics : JCO, 1988, Volume: 22, Issue:5 Topics: Alkaloids; Anti-Infective Agents; Benzophenanthridines; Child; Dental Plaque; Double-Blind Method; G	1988
Longitudinal evaluation of sanguinaria: clinical and microbiologic studies. The Compendium of continuing education in dentistry, 1986, Volume: Suppl 7 Topics: Adolescent; Adult; Alkaloids; Bacteria; Benzophenanthridines; Child; Dental Plaque; Female; Gingivit	1986
The effects of a sanguinaria dentrifice on plaque and gingivitis. The Compendium of continuing education in dentistry, 1986, Volume: Suppl 7 Topics: Adult; Aged; Alkaloids; Benzophenanthridines; Dental Plaque; Double-Blind Method; Female; Gingivitis	1986
Effect of 0.03% sanguinaria rinse on plaque and gingivitis when delivered as a manual rinse and under pressure in an oral irrigator. The Compendium of continuing education in dentistry, 1986, Volume: Suppl 7 Topics: Adult; Alkaloids; Benzophenanthridines; Dental Devices, Home Care; Dental Plaque; Gingivitis; Humans	1986
The effect of mouthrinses on parameters characterizing human periodontal disease. The Compendium of continuing education in dentistry, 1986, Volume: Suppl 7 Topics: Adult; Alkaloids; Benzophenanthridines; Chlorhexidine; Dental Plaque; Female; Gingivitis; Humans; Is	1986
Sanguinarine and essential oil mouthrinses. Effects on plaque and gingivitis. Dental hygiene, 1987, Volume: 61, Issue:2 Topics: Adult; Alkaloids; Benzophenanthridines; Dental Plaque; Female; Gingivitis; Humans; Isoquinolines; Ma	1987
Crevicular delivery of sanguinaria to control gingivitis. Journal of the American Dental Association (1939), 1987, Volume: 114, Issue:5 Topics: Alkaloids; Anti-Infective Agents; Benzophenanthridines; Dental Devices, Home Care; Dental Prophylaxi	1987
Effect of sanguinaria extract on established plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. Journal of clinical periodontology, 1987, Volume: 14, Issue:7 Topics: Adult; Alkaloids; Anti-Infective Agents; Benzophenanthridines; Dental Devices, Home Care; Dental Pla	1987
Questions on use of sanguinaria. Journal of the American Dental Association (1939), 1987, Volume: 115, Issue:5 Topics: Alkaloids; Benzophenanthridines; Gingivitis; Humans; Isoquinolines	1987