sampangine and AIDS-Related-Opportunistic-Infections

sampangine has been researched along with AIDS-Related-Opportunistic-Infections* in 1 studies

Other Studies

1 other study(ies) available for sampangine and AIDS-Related-Opportunistic-Infections

Article	Year
Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines. Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22 Several A- and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of the sampangine B-ring at position 4, while the synthesis of A-ring 3-substituted sampangines and benzo[4,5]sampangine (24) were achieved from the corresponding functionalized cleistopholines. Two-dimensional NMR spectroscopy was used to rigorously characterize the A- and B-ring substituent patterns. Structure-activity relationship studies revealed the activity of the sampangines was enhanced by the presence of a substituent at position 3 or by a 4,5-benzo group. Topics: AIDS-Related Opportunistic Infections; Alkaloids; Anti-Bacterial Agents; Antifungal Agents; Aporphines; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium avium Complex; Structure-Activity Relationship; X-Ray Diffraction	1992

Article

Year

Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines.

Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22

Several A- and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of the sampangine B-ring at position 4, while the synthesis of A-ring 3-substituted sampangines and benzo[4,5]sampangine (24) were achieved from the corresponding functionalized cleistopholines. Two-dimensional NMR spectroscopy was used to rigorously characterize the A- and B-ring substituent patterns. Structure-activity relationship studies revealed the activity of the sampangines was enhanced by the presence of a substituent at position 3 or by a 4,5-benzo group.

Topics: AIDS-Related Opportunistic Infections; Alkaloids; Anti-Bacterial Agents; Antifungal Agents; Aporphines; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium avium Complex; Structure-Activity Relationship; X-Ray Diffraction

1992