salvianolic-acid-c has been researched along with Disease-Models--Animal* in 2 studies
2 other study(ies) available for salvianolic-acid-c and Disease-Models--Animal
| Article | Year |
|---|---|
Isosalvianolic acid C-induced pseudo-allergic reactions via the mast cell specific receptor MRGPRX2.
Pseudo-allergic reactions occurred in patients administered drugs for the first time, seriously threaten man's survival. Due to the frequent reports of pseudo-allergic reactions to Danshen injection, in our previous study, isosalvianolic acid C in Danshen injection was found to trigger off mast cell degranulation. However, the direct involvement and the mechanisms underlying pseudo-allergic reactions have not been elucidated. In this study, the pseudo-allergic reactions induced by isosalvianolic acid C were confirmed by an ear swelling assay, a hindpaw swelling and extravasation assay in vivo and mast cell degranulation assays in vitro. We also evaluated whether the pseudo-allergic effect is related to MRGPRX2, Isosalvianolic acid C induced Ca Topics: Alkenes; Anaphylaxis; Animals; Calcium Signaling; Cell Degranulation; Disease Models, Animal; HEK293 Cells; Humans; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Phospholipase C gamma; Polyphenols; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction | 2019 |
Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.
Topics: Acetaminophen; Alkenes; Animals; Anti-Inflammatory Agents; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Heme Oxygenase-1; Humans; Inflammation; Inflammation Mediators; Kelch-Like ECH-Associated Protein 1; Male; Membrane Proteins; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Polyphenols; Salvia miltiorrhiza; Signal Transduction | 2019 |