salvianolic-acid-c and Aortic-Aneurysm

Aortic aneurysm is a disastrous vascular disease with high morbidity and mortality. Matrix metalloproteinases (MMPs), especially MMP-9, is implicated in the development of aortic aneurysm, but the effective MMP inhibitors are far from development. To develop new candidate compound for aortic aneurysm therapy, we evaluated the effects of salvianolic acid C (SalC) against the formation of aortic aneurysm.. Aortic aneurysm was induced by implantation of angiotension II (AngII) minipump in apolipoprotein E-deficient (ApoE. SalC significantly ameliorated the progression of aortic aneurysm in ApoE

Topics: Alkenes; Animals; Aorta; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Apolipoproteins E; Elastin; Gene Deletion; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice, Inbred C57BL; Polyphenols