salvianolic-acid-c and Anaphylaxis

Pseudo-allergic reactions occurred in patients administered drugs for the first time, seriously threaten man's survival. Due to the frequent reports of pseudo-allergic reactions to Danshen injection, in our previous study, isosalvianolic acid C in Danshen injection was found to trigger off mast cell degranulation. However, the direct involvement and the mechanisms underlying pseudo-allergic reactions have not been elucidated. In this study, the pseudo-allergic reactions induced by isosalvianolic acid C were confirmed by an ear swelling assay, a hindpaw swelling and extravasation assay in vivo and mast cell degranulation assays in vitro. We also evaluated whether the pseudo-allergic effect is related to MRGPRX2, Isosalvianolic acid C induced Ca

Topics: Alkenes; Anaphylaxis; Animals; Calcium Signaling; Cell Degranulation; Disease Models, Animal; HEK293 Cells; Humans; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Phospholipase C gamma; Polyphenols; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction